Summary | |
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Symbol | SPRED1 |
Name | sprouty-related, EVH1 domain containing 1 |
Aliases | FLJ33903; PPP1R147; protein phosphatase 1, regulatory subunit 147; NFLS; hSpred1; spred-1; suppressor of Ras ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Peripheral membrane protein Membrane, caveola Peripheral membrane protein Nucleus Note=Localized in cholesterol-rich membrane raft/caveola fractions. |
Domain |
PF05210 Sprouty protein (Spry) PF00568 WH1 domain |
Function |
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity). |
Biological Process |
GO:0000188 inactivation of MAPK activity GO:0001933 negative regulation of protein phosphorylation GO:0006469 negative regulation of protein kinase activity GO:0006476 protein deacetylation GO:0008543 fibroblast growth factor receptor signaling pathway GO:0010799 regulation of peptidyl-threonine phosphorylation GO:0010801 negative regulation of peptidyl-threonine phosphorylation GO:0010921 regulation of phosphatase activity GO:0010923 negative regulation of phosphatase activity GO:0016311 dephosphorylation GO:0018107 peptidyl-threonine phosphorylation GO:0018210 peptidyl-threonine modification GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0033673 negative regulation of kinase activity GO:0035303 regulation of dephosphorylation GO:0035305 negative regulation of dephosphorylation GO:0035601 protein deacylation GO:0042326 negative regulation of phosphorylation GO:0042770 signal transduction in response to DNA damage GO:0043405 regulation of MAP kinase activity GO:0043407 negative regulation of MAP kinase activity GO:0043409 negative regulation of MAPK cascade GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator GO:0044344 cellular response to fibroblast growth factor stimulus GO:0051346 negative regulation of hydrolase activity GO:0051348 negative regulation of transferase activity GO:0071774 response to fibroblast growth factor GO:0071900 regulation of protein serine/threonine kinase activity GO:0071901 negative regulation of protein serine/threonine kinase activity GO:0072331 signal transduction by p53 class mediator GO:0090311 regulation of protein deacetylation GO:0098732 macromolecule deacylation GO:1901796 regulation of signal transduction by p53 class mediator GO:1901798 positive regulation of signal transduction by p53 class mediator GO:1902532 negative regulation of intracellular signal transduction GO:2001020 regulation of response to DNA damage stimulus GO:2001022 positive regulation of response to DNA damage stimulus |
Molecular Function |
GO:0004857 enzyme inhibitor activity GO:0004860 protein kinase inhibitor activity GO:0005126 cytokine receptor binding GO:0005173 stem cell factor receptor binding GO:0019207 kinase regulator activity GO:0019210 kinase inhibitor activity GO:0019887 protein kinase regulator activity GO:0019902 phosphatase binding GO:0030291 protein serine/threonine kinase inhibitor activity |
Cellular Component |
GO:0005901 caveola GO:0044853 plasma membrane raft GO:0045121 membrane raft GO:0098589 membrane region GO:0098857 membrane microdomain |
KEGG | - |
Reactome |
R-HSA-170984: ARMS-mediated activation R-HSA-422475: Axon guidance R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-1266738: Developmental Biology R-HSA-186763: Downstream signal transduction R-HSA-2871796: FCERI mediated MAPK activation R-HSA-5658623: FGFRL1 modulation of FGFR1 signaling R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-170968: Frs2-mediated activation R-HSA-179812: GRB2 events in EGFR signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-912526: Interleukin receptor SHC signaling R-HSA-451927: Interleukin-2 signaling R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling R-HSA-5683057: MAPK family signaling cascades R-HSA-5684996: MAPK1/MAPK3 signaling R-HSA-375165: NCAM signaling for neurite out-growth R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-8849471: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases R-HSA-169893: Prolonged ERK activation events R-HSA-5673001: RAF/MAP kinase cascade R-HSA-8853659: RET signaling R-HSA-5658442: Regulation of RAS by GAPs R-HSA-180336: SHC1 events in EGFR signaling R-HSA-112412: SOS-mediated signalling R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-190236: Signaling by FGFR R-HSA-5654736: Signaling by FGFR1 R-HSA-372790: Signaling by GPCR R-HSA-74752: Signaling by Insulin receptor R-HSA-449147: Signaling by Interleukins R-HSA-2586552: Signaling by Leptin R-HSA-186797: Signaling by PDGF R-HSA-8848021: Signaling by PTK6 R-HSA-1433557: Signaling by SCF-KIT R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-194138: Signaling by VEGF R-HSA-166520: Signalling by NGF R-HSA-187687: Signalling to ERKs R-HSA-167044: Signalling to RAS R-HSA-187706: Signalling to p38 via RIT and RIN R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-5218921: VEGFR2 mediated cell proliferation |
Summary | |
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Symbol | SPRED1 |
Name | sprouty-related, EVH1 domain containing 1 |
Aliases | FLJ33903; PPP1R147; protein phosphatase 1, regulatory subunit 147; NFLS; hSpred1; spred-1; suppressor of Ras ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SPRED1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SPRED1 |
Name | sprouty-related, EVH1 domain containing 1 |
Aliases | FLJ33903; PPP1R147; protein phosphatase 1, regulatory subunit 147; NFLS; hSpred1; spred-1; suppressor of Ras ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SPRED1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SPRED1 |
Name | sprouty-related, EVH1 domain containing 1 |
Aliases | FLJ33903; PPP1R147; protein phosphatase 1, regulatory subunit 147; NFLS; hSpred1; spred-1; suppressor of Ras ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SPRED1 in various data sets.
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Points in the above scatter plot represent the mutation difference of SPRED1 in various data sets.
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Summary | |
---|---|
Symbol | SPRED1 |
Name | sprouty-related, EVH1 domain containing 1 |
Aliases | FLJ33903; PPP1R147; protein phosphatase 1, regulatory subunit 147; NFLS; hSpred1; spred-1; suppressor of Ras ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SPRED1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SPRED1 |
Name | sprouty-related, EVH1 domain containing 1 |
Aliases | FLJ33903; PPP1R147; protein phosphatase 1, regulatory subunit 147; NFLS; hSpred1; spred-1; suppressor of Ras ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SPRED1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SPRED1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SPRED1 |
Name | sprouty-related, EVH1 domain containing 1 |
Aliases | FLJ33903; PPP1R147; protein phosphatase 1, regulatory subunit 147; NFLS; hSpred1; spred-1; suppressor of Ras ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SPRED1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SPRED1 |
Name | sprouty-related, EVH1 domain containing 1 |
Aliases | FLJ33903; PPP1R147; protein phosphatase 1, regulatory subunit 147; NFLS; hSpred1; spred-1; suppressor of Ras ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SPRED1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SPRED1 |
Name | sprouty-related, EVH1 domain containing 1 |
Aliases | FLJ33903; PPP1R147; protein phosphatase 1, regulatory subunit 147; NFLS; hSpred1; spred-1; suppressor of Ras ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SPRED1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | SPRED1 |
Name | sprouty-related, EVH1 domain containing 1 |
Aliases | FLJ33903; PPP1R147; protein phosphatase 1, regulatory subunit 147; NFLS; hSpred1; spred-1; suppressor of Ras ...... |
Chromosomal Location | 15q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SPRED1 collected from DrugBank database. |
There is no record. |