Summary | |
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Symbol | SRP19 |
Name | signal recognition particle 19kDa |
Aliases | signal recognition particle 19kD; Signal recognition particle 19 kDa protein |
Chromosomal Location | 5q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. |
Domain |
PF01922 SRP19 protein |
Function |
Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP. |
Biological Process |
GO:0006612 protein targeting to membrane GO:0006613 cotranslational protein targeting to membrane GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0042493 response to drug GO:0045047 protein targeting to ER GO:0070972 protein localization to endoplasmic reticulum GO:0072599 establishment of protein localization to endoplasmic reticulum GO:0072657 protein localization to membrane GO:0090150 establishment of protein localization to membrane |
Molecular Function |
GO:0008312 7S RNA binding |
Cellular Component |
GO:0005786 signal recognition particle, endoplasmic reticulum targeting GO:0048500 signal recognition particle |
KEGG |
hsa03060 Protein export |
Reactome |
R-HSA-74160: Gene Expression R-HSA-392499: Metabolism of proteins R-HSA-1799339: SRP-dependent cotranslational protein targeting to membrane R-HSA-72766: Translation |
Summary | |
---|---|
Symbol | SRP19 |
Name | signal recognition particle 19kDa |
Aliases | signal recognition particle 19kD; Signal recognition particle 19 kDa protein |
Chromosomal Location | 5q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SRP19 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SRP19 |
Name | signal recognition particle 19kDa |
Aliases | signal recognition particle 19kD; Signal recognition particle 19 kDa protein |
Chromosomal Location | 5q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SRP19 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | SRP19 |
Name | signal recognition particle 19kDa |
Aliases | signal recognition particle 19kD; Signal recognition particle 19 kDa protein |
Chromosomal Location | 5q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SRP19 in various data sets.
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Points in the above scatter plot represent the mutation difference of SRP19 in various data sets.
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Summary | |
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Symbol | SRP19 |
Name | signal recognition particle 19kDa |
Aliases | signal recognition particle 19kD; Signal recognition particle 19 kDa protein |
Chromosomal Location | 5q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SRP19. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SRP19 |
Name | signal recognition particle 19kDa |
Aliases | signal recognition particle 19kD; Signal recognition particle 19 kDa protein |
Chromosomal Location | 5q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SRP19. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SRP19. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SRP19 |
Name | signal recognition particle 19kDa |
Aliases | signal recognition particle 19kD; Signal recognition particle 19 kDa protein |
Chromosomal Location | 5q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SRP19. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SRP19 |
Name | signal recognition particle 19kDa |
Aliases | signal recognition particle 19kD; Signal recognition particle 19 kDa protein |
Chromosomal Location | 5q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SRP19 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SRP19 |
Name | signal recognition particle 19kDa |
Aliases | signal recognition particle 19kD; Signal recognition particle 19 kDa protein |
Chromosomal Location | 5q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SRP19 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SRP19 |
Name | signal recognition particle 19kDa |
Aliases | signal recognition particle 19kD; Signal recognition particle 19 kDa protein |
Chromosomal Location | 5q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SRP19 collected from DrugBank database. |
There is no record. |