Summary | |
---|---|
Symbol | SRPX2 |
Name | sushi-repeat containing protein, X-linked 2 |
Aliases | SRPUL; sushi-repeat-containing protein, X-linked 2; BPP; CBPS; PMGX; RESDX; sushi-repeat protein up-regulate ...... |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. Cytoplasm. Cell surface. Cell junction, synapse |
Domain |
PF13778 Domain of unknown function (DUF4174) PF02494 HYR domain PF00084 Sushi repeat (SCR repeat) |
Function |
Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development. |
Biological Process |
GO:0001525 angiogenesis GO:0001667 ameboidal-type cell migration GO:0002040 sprouting angiogenesis GO:0002042 cell migration involved in sprouting angiogenesis GO:0007416 synapse assembly GO:0010594 regulation of endothelial cell migration GO:0010595 positive regulation of endothelial cell migration GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010634 positive regulation of epithelial cell migration GO:0030335 positive regulation of cell migration GO:0040017 positive regulation of locomotion GO:0043534 blood vessel endothelial cell migration GO:0043535 regulation of blood vessel endothelial cell migration GO:0043536 positive regulation of blood vessel endothelial cell migration GO:0043542 endothelial cell migration GO:0044089 positive regulation of cellular component biogenesis GO:0044708 single-organism behavior GO:0045765 regulation of angiogenesis GO:0045766 positive regulation of angiogenesis GO:0048514 blood vessel morphogenesis GO:0050803 regulation of synapse structure or activity GO:0050807 regulation of synapse organization GO:0050808 synapse organization GO:0051272 positive regulation of cellular component movement GO:0051962 positive regulation of nervous system development GO:0051963 regulation of synapse assembly GO:0051965 positive regulation of synapse assembly GO:0071625 vocalization behavior GO:0090049 regulation of cell migration involved in sprouting angiogenesis GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis GO:0090130 tissue migration GO:0090132 epithelium migration GO:1901342 regulation of vasculature development GO:1903670 regulation of sprouting angiogenesis GO:1903672 positive regulation of sprouting angiogenesis GO:1904018 positive regulation of vasculature development GO:2000147 positive regulation of cell motility |
Molecular Function |
GO:0019838 growth factor binding GO:0036458 hepatocyte growth factor binding |
Cellular Component |
GO:0060076 excitatory synapse GO:0097060 synaptic membrane |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | SRPX2 |
Name | sushi-repeat containing protein, X-linked 2 |
Aliases | SRPUL; sushi-repeat-containing protein, X-linked 2; BPP; CBPS; PMGX; RESDX; sushi-repeat protein up-regulate ...... |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SRPX2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SRPX2 |
Name | sushi-repeat containing protein, X-linked 2 |
Aliases | SRPUL; sushi-repeat-containing protein, X-linked 2; BPP; CBPS; PMGX; RESDX; sushi-repeat protein up-regulate ...... |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of SRPX2 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | SRPX2 |
Name | sushi-repeat containing protein, X-linked 2 |
Aliases | SRPUL; sushi-repeat-containing protein, X-linked 2; BPP; CBPS; PMGX; RESDX; sushi-repeat protein up-regulate ...... |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SRPX2 in various data sets.
|
Points in the above scatter plot represent the mutation difference of SRPX2 in various data sets.
|
Summary | |
---|---|
Symbol | SRPX2 |
Name | sushi-repeat containing protein, X-linked 2 |
Aliases | SRPUL; sushi-repeat-containing protein, X-linked 2; BPP; CBPS; PMGX; RESDX; sushi-repeat protein up-regulate ...... |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SRPX2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SRPX2 |
Name | sushi-repeat containing protein, X-linked 2 |
Aliases | SRPUL; sushi-repeat-containing protein, X-linked 2; BPP; CBPS; PMGX; RESDX; sushi-repeat protein up-regulate ...... |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SRPX2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SRPX2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SRPX2 |
Name | sushi-repeat containing protein, X-linked 2 |
Aliases | SRPUL; sushi-repeat-containing protein, X-linked 2; BPP; CBPS; PMGX; RESDX; sushi-repeat protein up-regulate ...... |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SRPX2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SRPX2 |
Name | sushi-repeat containing protein, X-linked 2 |
Aliases | SRPUL; sushi-repeat-containing protein, X-linked 2; BPP; CBPS; PMGX; RESDX; sushi-repeat protein up-regulate ...... |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SRPX2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SRPX2 |
Name | sushi-repeat containing protein, X-linked 2 |
Aliases | SRPUL; sushi-repeat-containing protein, X-linked 2; BPP; CBPS; PMGX; RESDX; sushi-repeat protein up-regulate ...... |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SRPX2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SRPX2 |
Name | sushi-repeat containing protein, X-linked 2 |
Aliases | SRPUL; sushi-repeat-containing protein, X-linked 2; BPP; CBPS; PMGX; RESDX; sushi-repeat protein up-regulate ...... |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SRPX2 collected from DrugBank database. |
There is no record. |