Browse SRRT

Summary
SymbolSRRT
Nameserrate, RNA effector molecule
Aliases Asr2; serrate; ARS2; arsenite resistance protein; serrate RNA effector molecule homolog (Arabidopsis); arsen ......
Chromosomal Location7q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus, nucleoplasm Cytoplasm Note=Predominantly nuclear. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way (By similarity).
Domain PF04959 Arsenite-resistance protein 2
PF12066 Domain of unknown function (DUF3546)
Function

Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).

> Gene Ontology
 
Biological Process GO:0000375 RNA splicing, via transesterification reactions
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0006417 regulation of translation
GO:0008380 RNA splicing
GO:0009301 snRNA transcription
GO:0010608 posttranscriptional regulation of gene expression
GO:0010720 positive regulation of cell development
GO:0016073 snRNA metabolic process
GO:0016441 posttranscriptional gene silencing
GO:0016458 gene silencing
GO:0017148 negative regulation of translation
GO:0019827 stem cell population maintenance
GO:0031047 gene silencing by RNA
GO:0031050 dsRNA fragmentation
GO:0031053 primary miRNA processing
GO:0034248 regulation of cellular amide metabolic process
GO:0034249 negative regulation of cellular amide metabolic process
GO:0034470 ncRNA processing
GO:0035194 posttranscriptional gene silencing by RNA
GO:0035195 gene silencing by miRNA
GO:0035196 production of miRNAs involved in gene silencing by miRNA
GO:0040029 regulation of gene expression, epigenetic
GO:0042795 snRNA transcription from RNA polymerase II promoter
GO:0043331 response to dsRNA
GO:0046685 response to arsenic-containing substance
GO:0050769 positive regulation of neurogenesis
GO:0051962 positive regulation of nervous system development
GO:0070918 production of small RNA involved in gene silencing by RNA
GO:0071359 cellular response to dsRNA
GO:0071407 cellular response to organic cyclic compound
GO:0097150 neuronal stem cell population maintenance
GO:0098727 maintenance of cell number
GO:0098781 ncRNA transcription
Molecular Function -
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-74160: Gene Expression
R-HSA-72203: Processing of Capped Intron-Containing Pre-mRNA
R-HSA-6807505: RNA polymerase II transcribes snRNA genes
R-HSA-72172: mRNA Splicing
R-HSA-72163: mRNA Splicing - Major Pathway
Summary
SymbolSRRT
Nameserrate, RNA effector molecule
Aliases Asr2; serrate; ARS2; arsenite resistance protein; serrate RNA effector molecule homolog (Arabidopsis); arsen ......
Chromosomal Location7q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SRRT and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolSRRT
Nameserrate, RNA effector molecule
Aliases Asr2; serrate; ARS2; arsenite resistance protein; serrate RNA effector molecule homolog (Arabidopsis); arsen ......
Chromosomal Location7q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SRRT in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSRRT
Nameserrate, RNA effector molecule
Aliases Asr2; serrate; ARS2; arsenite resistance protein; serrate RNA effector molecule homolog (Arabidopsis); arsen ......
Chromosomal Location7q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SRRT in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1870.371
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1780.942
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1970.915
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2150.431
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1890.941
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.250.941
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.060.875
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0040.998
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1650.932
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.5870.734
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.8340.744
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1460.00388
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SRRT in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.82.712.10.0439
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.83.411.40.0746
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSRRT
Nameserrate, RNA effector molecule
Aliases Asr2; serrate; ARS2; arsenite resistance protein; serrate RNA effector molecule homolog (Arabidopsis); arsen ......
Chromosomal Location7q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SRRT. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSRRT
Nameserrate, RNA effector molecule
Aliases Asr2; serrate; ARS2; arsenite resistance protein; serrate RNA effector molecule homolog (Arabidopsis); arsen ......
Chromosomal Location7q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SRRT. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SRRT.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSRRT
Nameserrate, RNA effector molecule
Aliases Asr2; serrate; ARS2; arsenite resistance protein; serrate RNA effector molecule homolog (Arabidopsis); arsen ......
Chromosomal Location7q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SRRT. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSRRT
Nameserrate, RNA effector molecule
Aliases Asr2; serrate; ARS2; arsenite resistance protein; serrate RNA effector molecule homolog (Arabidopsis); arsen ......
Chromosomal Location7q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SRRT expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSRRT
Nameserrate, RNA effector molecule
Aliases Asr2; serrate; ARS2; arsenite resistance protein; serrate RNA effector molecule homolog (Arabidopsis); arsen ......
Chromosomal Location7q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SRRT and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSRRT
Nameserrate, RNA effector molecule
Aliases Asr2; serrate; ARS2; arsenite resistance protein; serrate RNA effector molecule homolog (Arabidopsis); arsen ......
Chromosomal Location7q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SRRT collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.