Summary | |
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Symbol | SSTR2 |
Name | somatostatin receptor 2 |
Aliases | SRIF-1; SS2R; SS2-R; SS-2-R; Somatostatin receptor type 2 |
Chromosomal Location | 17q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm. |
Domain |
PF00001 7 transmembrane receptor (rhodopsin family) |
Function |
Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. |
Biological Process |
GO:0003012 muscle system process GO:0006936 muscle contraction GO:0006937 regulation of muscle contraction GO:0006939 smooth muscle contraction GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007218 neuropeptide signaling pathway GO:0007283 spermatogenesis GO:0007584 response to nutrient GO:0007586 digestion GO:0009755 hormone-mediated signaling pathway GO:0009991 response to extracellular stimulus GO:0014821 phasic smooth muscle contraction GO:0021549 cerebellum development GO:0022037 metencephalon development GO:0030432 peristalsis GO:0030900 forebrain development GO:0030902 hindbrain development GO:0031667 response to nutrient levels GO:0031960 response to corticosteroid GO:0032355 response to estradiol GO:0038169 somatostatin receptor signaling pathway GO:0038170 somatostatin signaling pathway GO:0042594 response to starvation GO:0044057 regulation of system process GO:0048232 male gamete generation GO:0048545 response to steroid hormone GO:0051384 response to glucocorticoid GO:0071383 cellular response to steroid hormone stimulus GO:0071384 cellular response to corticosteroid stimulus GO:0071385 cellular response to glucocorticoid stimulus GO:0071392 cellular response to estradiol stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0090257 regulation of muscle system process |
Molecular Function |
GO:0001653 peptide receptor activity GO:0004994 somatostatin receptor activity GO:0008188 neuropeptide receptor activity GO:0008528 G-protein coupled peptide receptor activity GO:0030165 PDZ domain binding GO:0033218 amide binding GO:0042277 peptide binding GO:0042923 neuropeptide binding |
Cellular Component | - |
KEGG |
hsa04024 cAMP signaling pathway hsa04080 Neuroactive ligand-receptor interaction hsa04971 Gastric acid secretion |
Reactome |
R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-418594: G alpha (i) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-375276: Peptide ligand-binding receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | SSTR2 |
Name | somatostatin receptor 2 |
Aliases | SRIF-1; SS2R; SS2-R; SS-2-R; Somatostatin receptor type 2 |
Chromosomal Location | 17q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SSTR2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | SSTR2 |
Name | somatostatin receptor 2 |
Aliases | SRIF-1; SS2R; SS2-R; SS-2-R; Somatostatin receptor type 2 |
Chromosomal Location | 17q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SSTR2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SSTR2 |
Name | somatostatin receptor 2 |
Aliases | SRIF-1; SS2R; SS2-R; SS-2-R; Somatostatin receptor type 2 |
Chromosomal Location | 17q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SSTR2 in various data sets.
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Points in the above scatter plot represent the mutation difference of SSTR2 in various data sets.
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Summary | |
---|---|
Symbol | SSTR2 |
Name | somatostatin receptor 2 |
Aliases | SRIF-1; SS2R; SS2-R; SS-2-R; Somatostatin receptor type 2 |
Chromosomal Location | 17q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SSTR2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SSTR2 |
Name | somatostatin receptor 2 |
Aliases | SRIF-1; SS2R; SS2-R; SS-2-R; Somatostatin receptor type 2 |
Chromosomal Location | 17q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SSTR2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SSTR2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SSTR2 |
Name | somatostatin receptor 2 |
Aliases | SRIF-1; SS2R; SS2-R; SS-2-R; Somatostatin receptor type 2 |
Chromosomal Location | 17q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SSTR2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SSTR2 |
Name | somatostatin receptor 2 |
Aliases | SRIF-1; SS2R; SS2-R; SS-2-R; Somatostatin receptor type 2 |
Chromosomal Location | 17q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SSTR2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SSTR2 |
Name | somatostatin receptor 2 |
Aliases | SRIF-1; SS2R; SS2-R; SS-2-R; Somatostatin receptor type 2 |
Chromosomal Location | 17q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SSTR2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | SSTR2 |
Name | somatostatin receptor 2 |
Aliases | SRIF-1; SS2R; SS2-R; SS-2-R; Somatostatin receptor type 2 |
Chromosomal Location | 17q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SSTR2 collected from DrugBank database. |
Details on drugs targeting SSTR2.
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