Summary | |
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Symbol | SSTR5 |
Name | somatostatin receptor 5 |
Aliases | SS-5-R; somatostatin receptor subtype 5; SS5R; SS5-R; Somatostatin receptor type 5 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF00001 7 transmembrane receptor (rhodopsin family) |
Function |
Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization. |
Biological Process |
GO:0000910 cytokinesis GO:0002790 peptide secretion GO:0002791 regulation of peptide secretion GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0009306 protein secretion GO:0009755 hormone-mediated signaling pathway GO:0009914 hormone transport GO:0010817 regulation of hormone levels GO:0015833 peptide transport GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030073 insulin secretion GO:0031960 response to corticosteroid GO:0032465 regulation of cytokinesis GO:0032467 positive regulation of cytokinesis GO:0033500 carbohydrate homeostasis GO:0038169 somatostatin receptor signaling pathway GO:0038170 somatostatin signaling pathway GO:0042593 glucose homeostasis GO:0042886 amide transport GO:0045787 positive regulation of cell cycle GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0048545 response to steroid hormone GO:0050708 regulation of protein secretion GO:0050796 regulation of insulin secretion GO:0051302 regulation of cell division GO:0051384 response to glucocorticoid GO:0051781 positive regulation of cell division GO:0071383 cellular response to steroid hormone stimulus GO:0071384 cellular response to corticosteroid stimulus GO:0071385 cellular response to glucocorticoid stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0090068 positive regulation of cell cycle process GO:0090087 regulation of peptide transport GO:0090276 regulation of peptide hormone secretion |
Molecular Function |
GO:0001653 peptide receptor activity GO:0004994 somatostatin receptor activity GO:0008188 neuropeptide receptor activity GO:0008528 G-protein coupled peptide receptor activity GO:0033218 amide binding GO:0042277 peptide binding GO:0042923 neuropeptide binding |
Cellular Component | - |
KEGG |
hsa04024 cAMP signaling pathway hsa04080 Neuroactive ligand-receptor interaction |
Reactome |
R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-418594: G alpha (i) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-375276: Peptide ligand-binding receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | SSTR5 |
Name | somatostatin receptor 5 |
Aliases | SS-5-R; somatostatin receptor subtype 5; SS5R; SS5-R; Somatostatin receptor type 5 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SSTR5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SSTR5 |
Name | somatostatin receptor 5 |
Aliases | SS-5-R; somatostatin receptor subtype 5; SS5R; SS5-R; Somatostatin receptor type 5 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SSTR5 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | SSTR5 |
Name | somatostatin receptor 5 |
Aliases | SS-5-R; somatostatin receptor subtype 5; SS5R; SS5-R; Somatostatin receptor type 5 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SSTR5 in various data sets.
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Points in the above scatter plot represent the mutation difference of SSTR5 in various data sets.
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Summary | |
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Symbol | SSTR5 |
Name | somatostatin receptor 5 |
Aliases | SS-5-R; somatostatin receptor subtype 5; SS5R; SS5-R; Somatostatin receptor type 5 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SSTR5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SSTR5 |
Name | somatostatin receptor 5 |
Aliases | SS-5-R; somatostatin receptor subtype 5; SS5R; SS5-R; Somatostatin receptor type 5 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SSTR5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SSTR5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SSTR5 |
Name | somatostatin receptor 5 |
Aliases | SS-5-R; somatostatin receptor subtype 5; SS5R; SS5-R; Somatostatin receptor type 5 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SSTR5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SSTR5 |
Name | somatostatin receptor 5 |
Aliases | SS-5-R; somatostatin receptor subtype 5; SS5R; SS5-R; Somatostatin receptor type 5 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SSTR5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SSTR5 |
Name | somatostatin receptor 5 |
Aliases | SS-5-R; somatostatin receptor subtype 5; SS5R; SS5-R; Somatostatin receptor type 5 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SSTR5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SSTR5 |
Name | somatostatin receptor 5 |
Aliases | SS-5-R; somatostatin receptor subtype 5; SS5R; SS5-R; Somatostatin receptor type 5 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SSTR5 collected from DrugBank database. |
Details on drugs targeting SSTR5.
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