Summary | |
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Symbol | SSU72 |
Name | SSU72 homolog, RNA polymerase II CTD phosphatase |
Aliases | HSPC182; Ssu72 RNA polymerase II CTD phosphatase homolog (yeast); SSU72 RNA polymerase II CTD phosphatase ho ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. Cytoplasm. Note=Predominantly in the cytosol. |
Domain |
PF04722 Ssu72-like protein |
Function |
Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK. |
Biological Process |
GO:0006353 DNA-templated transcription, termination GO:0006369 termination of RNA polymerase II transcription GO:0006378 mRNA polyadenylation GO:0006397 mRNA processing GO:0006470 protein dephosphorylation GO:0016311 dephosphorylation GO:0031123 RNA 3'-end processing GO:0031124 mRNA 3'-end processing GO:0043631 RNA polyadenylation GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain |
Molecular Function |
GO:0004721 phosphoprotein phosphatase activity GO:0004722 protein serine/threonine phosphatase activity GO:0008420 CTD phosphatase activity GO:0016791 phosphatase activity GO:0042578 phosphoric ester hydrolase activity |
Cellular Component |
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex GO:0005849 mRNA cleavage factor complex |
KEGG |
hsa03015 mRNA surveillance pathway |
Reactome | - |
Summary | |
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Symbol | SSU72 |
Name | SSU72 homolog, RNA polymerase II CTD phosphatase |
Aliases | HSPC182; Ssu72 RNA polymerase II CTD phosphatase homolog (yeast); SSU72 RNA polymerase II CTD phosphatase ho ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SSU72 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SSU72 |
Name | SSU72 homolog, RNA polymerase II CTD phosphatase |
Aliases | HSPC182; Ssu72 RNA polymerase II CTD phosphatase homolog (yeast); SSU72 RNA polymerase II CTD phosphatase ho ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SSU72 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SSU72 |
Name | SSU72 homolog, RNA polymerase II CTD phosphatase |
Aliases | HSPC182; Ssu72 RNA polymerase II CTD phosphatase homolog (yeast); SSU72 RNA polymerase II CTD phosphatase ho ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SSU72 in various data sets.
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Points in the above scatter plot represent the mutation difference of SSU72 in various data sets.
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Summary | |
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Symbol | SSU72 |
Name | SSU72 homolog, RNA polymerase II CTD phosphatase |
Aliases | HSPC182; Ssu72 RNA polymerase II CTD phosphatase homolog (yeast); SSU72 RNA polymerase II CTD phosphatase ho ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SSU72. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SSU72 |
Name | SSU72 homolog, RNA polymerase II CTD phosphatase |
Aliases | HSPC182; Ssu72 RNA polymerase II CTD phosphatase homolog (yeast); SSU72 RNA polymerase II CTD phosphatase ho ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SSU72. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SSU72. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SSU72 |
Name | SSU72 homolog, RNA polymerase II CTD phosphatase |
Aliases | HSPC182; Ssu72 RNA polymerase II CTD phosphatase homolog (yeast); SSU72 RNA polymerase II CTD phosphatase ho ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SSU72. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SSU72 |
Name | SSU72 homolog, RNA polymerase II CTD phosphatase |
Aliases | HSPC182; Ssu72 RNA polymerase II CTD phosphatase homolog (yeast); SSU72 RNA polymerase II CTD phosphatase ho ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SSU72 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SSU72 |
Name | SSU72 homolog, RNA polymerase II CTD phosphatase |
Aliases | HSPC182; Ssu72 RNA polymerase II CTD phosphatase homolog (yeast); SSU72 RNA polymerase II CTD phosphatase ho ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SSU72 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SSU72 |
Name | SSU72 homolog, RNA polymerase II CTD phosphatase |
Aliases | HSPC182; Ssu72 RNA polymerase II CTD phosphatase homolog (yeast); SSU72 RNA polymerase II CTD phosphatase ho ...... |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SSU72 collected from DrugBank database. |
There is no record. |