Browse SSU72

Summary
SymbolSSU72
NameSSU72 homolog, RNA polymerase II CTD phosphatase
Aliases HSPC182; Ssu72 RNA polymerase II CTD phosphatase homolog (yeast); SSU72 RNA polymerase II CTD phosphatase ho ......
Chromosomal Location1p36
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus. Cytoplasm. Note=Predominantly in the cytosol.
Domain PF04722 Ssu72-like protein
Function

Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK.

> Gene Ontology
 
Biological Process GO:0006353 DNA-templated transcription, termination
GO:0006369 termination of RNA polymerase II transcription
GO:0006378 mRNA polyadenylation
GO:0006397 mRNA processing
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0031123 RNA 3'-end processing
GO:0031124 mRNA 3'-end processing
GO:0043631 RNA polyadenylation
GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain
Molecular Function GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0008420 CTD phosphatase activity
GO:0016791 phosphatase activity
GO:0042578 phosphoric ester hydrolase activity
Cellular Component GO:0005847 mRNA cleavage and polyadenylation specificity factor complex
GO:0005849 mRNA cleavage factor complex
> KEGG and Reactome Pathway
 
KEGG hsa03015 mRNA surveillance pathway
Reactome -
Summary
SymbolSSU72
NameSSU72 homolog, RNA polymerase II CTD phosphatase
Aliases HSPC182; Ssu72 RNA polymerase II CTD phosphatase homolog (yeast); SSU72 RNA polymerase II CTD phosphatase ho ......
Chromosomal Location1p36
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SSU72 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolSSU72
NameSSU72 homolog, RNA polymerase II CTD phosphatase
Aliases HSPC182; Ssu72 RNA polymerase II CTD phosphatase homolog (yeast); SSU72 RNA polymerase II CTD phosphatase ho ......
Chromosomal Location1p36
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SSU72 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -1.98; FDR: 0.04220 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolSSU72
NameSSU72 homolog, RNA polymerase II CTD phosphatase
Aliases HSPC182; Ssu72 RNA polymerase II CTD phosphatase homolog (yeast); SSU72 RNA polymerase II CTD phosphatase ho ......
Chromosomal Location1p36
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SSU72 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.230.542
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0520.986
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.4420.848
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3410.285
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0120.995
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.7590.765
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1280.759
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2810.88
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0030.999
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1380.939
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.1330.961
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0910.158
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SSU72 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSSU72
NameSSU72 homolog, RNA polymerase II CTD phosphatase
Aliases HSPC182; Ssu72 RNA polymerase II CTD phosphatase homolog (yeast); SSU72 RNA polymerase II CTD phosphatase ho ......
Chromosomal Location1p36
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SSU72. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSSU72
NameSSU72 homolog, RNA polymerase II CTD phosphatase
Aliases HSPC182; Ssu72 RNA polymerase II CTD phosphatase homolog (yeast); SSU72 RNA polymerase II CTD phosphatase ho ......
Chromosomal Location1p36
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SSU72. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SSU72.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSSU72
NameSSU72 homolog, RNA polymerase II CTD phosphatase
Aliases HSPC182; Ssu72 RNA polymerase II CTD phosphatase homolog (yeast); SSU72 RNA polymerase II CTD phosphatase ho ......
Chromosomal Location1p36
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SSU72. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSSU72
NameSSU72 homolog, RNA polymerase II CTD phosphatase
Aliases HSPC182; Ssu72 RNA polymerase II CTD phosphatase homolog (yeast); SSU72 RNA polymerase II CTD phosphatase ho ......
Chromosomal Location1p36
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SSU72 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSSU72
NameSSU72 homolog, RNA polymerase II CTD phosphatase
Aliases HSPC182; Ssu72 RNA polymerase II CTD phosphatase homolog (yeast); SSU72 RNA polymerase II CTD phosphatase ho ......
Chromosomal Location1p36
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SSU72 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSSU72
NameSSU72 homolog, RNA polymerase II CTD phosphatase
Aliases HSPC182; Ssu72 RNA polymerase II CTD phosphatase homolog (yeast); SSU72 RNA polymerase II CTD phosphatase ho ......
Chromosomal Location1p36
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SSU72 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.