Summary | |
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Symbol | ST6GAL1 |
Name | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 |
Aliases | ST6Gal I; SIAT1; sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase); ST6GalI; ST6N; B-cell an ...... |
Chromosomal Location | 3q27.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid. |
Domain |
PF00777 Glycosyltransferase family 29 (sialyltransferase) |
Function |
Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates. |
Biological Process |
GO:0006054 N-acetylneuraminate metabolic process GO:0006486 protein glycosylation GO:0006487 protein N-linked glycosylation GO:0006493 protein O-linked glycosylation GO:0006959 humoral immune response GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0009311 oligosaccharide metabolic process GO:0016266 O-glycan processing GO:0018196 peptidyl-asparagine modification GO:0018279 protein N-linked glycosylation via asparagine GO:0043413 macromolecule glycosylation GO:0044723 single-organism carbohydrate metabolic process GO:0070085 glycosylation GO:0097503 sialylation |
Molecular Function |
GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity GO:0008373 sialyltransferase activity GO:0016757 transferase activity, transferring glycosyl groups |
Cellular Component |
GO:0005795 Golgi stack GO:0030173 integral component of Golgi membrane GO:0031228 intrinsic component of Golgi membrane GO:0031300 intrinsic component of organelle membrane GO:0031301 integral component of organelle membrane GO:0031984 organelle subcompartment GO:0031985 Golgi cisterna GO:0032580 Golgi cisterna membrane GO:0098791 Golgi subcompartment |
KEGG |
hsa00510 N-Glycan biosynthesis hsa00514 Other types of O-glycan biosynthesis hsa01100 Metabolic pathways |
Reactome |
R-HSA-446203: Asparagine N-linked glycosylation R-HSA-446193: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-392499: Metabolism of proteins R-HSA-975577: N-Glycan antennae elongation R-HSA-975576: N-glycan antennae elongation in the medial/trans-Golgi R-HSA-5173105: O-linked glycosylation R-HSA-913709: O-linked glycosylation of mucins R-HSA-597592: Post-translational protein modification R-HSA-4085001: Sialic acid metabolism R-HSA-446219: Synthesis of substrates in N-glycan biosythesis R-HSA-977068: Termination of O-glycan biosynthesis R-HSA-948021: Transport to the Golgi and subsequent modification |
Summary | |
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Symbol | ST6GAL1 |
Name | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 |
Aliases | ST6Gal I; SIAT1; sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase); ST6GalI; ST6N; B-cell an ...... |
Chromosomal Location | 3q27.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ST6GAL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ST6GAL1 |
Name | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 |
Aliases | ST6Gal I; SIAT1; sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase); ST6GalI; ST6N; B-cell an ...... |
Chromosomal Location | 3q27.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ST6GAL1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ST6GAL1 |
Name | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 |
Aliases | ST6Gal I; SIAT1; sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase); ST6GalI; ST6N; B-cell an ...... |
Chromosomal Location | 3q27.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ST6GAL1 in various data sets.
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Points in the above scatter plot represent the mutation difference of ST6GAL1 in various data sets.
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Summary | |
---|---|
Symbol | ST6GAL1 |
Name | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 |
Aliases | ST6Gal I; SIAT1; sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase); ST6GalI; ST6N; B-cell an ...... |
Chromosomal Location | 3q27.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ST6GAL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ST6GAL1 |
Name | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 |
Aliases | ST6Gal I; SIAT1; sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase); ST6GalI; ST6N; B-cell an ...... |
Chromosomal Location | 3q27.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ST6GAL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ST6GAL1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ST6GAL1 |
Name | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 |
Aliases | ST6Gal I; SIAT1; sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase); ST6GalI; ST6N; B-cell an ...... |
Chromosomal Location | 3q27.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ST6GAL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ST6GAL1 |
Name | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 |
Aliases | ST6Gal I; SIAT1; sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase); ST6GalI; ST6N; B-cell an ...... |
Chromosomal Location | 3q27.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ST6GAL1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ST6GAL1 |
Name | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 |
Aliases | ST6Gal I; SIAT1; sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase); ST6GalI; ST6N; B-cell an ...... |
Chromosomal Location | 3q27.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ST6GAL1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ST6GAL1 |
Name | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 |
Aliases | ST6Gal I; SIAT1; sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase); ST6GalI; ST6N; B-cell an ...... |
Chromosomal Location | 3q27.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ST6GAL1 collected from DrugBank database. |
There is no record. |