Browse STAB2

Summary
SymbolSTAB2
Namestabilin 2
Aliases DKFZP434E0321; FELL; STAB-2; HARE; FEEL-2; hyaluronic acid receptor for endocytosis; FEEL2; FELE-2; FELL2; F ......
Chromosomal Location12q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Single-pass type I membrane protein Cytoplasm Note=Only a small amount appears to be present at the cell surface (PubMed:17145755).
Domain PF12947 EGF domain
PF02469 Fasciclin domain
PF00193 Extracellular link domain
Function

Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS.

> Gene Ontology
 
Biological Process GO:0001525 angiogenesis
GO:0006022 aminoglycan metabolic process
GO:0006026 aminoglycan catabolic process
GO:0006027 glycosaminoglycan catabolic process
GO:0006898 receptor-mediated endocytosis
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0030193 regulation of blood coagulation
GO:0030203 glycosaminoglycan metabolic process
GO:0030212 hyaluronan metabolic process
GO:0030214 hyaluronan catabolic process
GO:0042742 defense response to bacterium
GO:0048514 blood vessel morphogenesis
GO:0050817 coagulation
GO:0050818 regulation of coagulation
GO:0050878 regulation of body fluid levels
GO:0061041 regulation of wound healing
GO:0098542 defense response to other organism
GO:1900046 regulation of hemostasis
GO:1901136 carbohydrate derivative catabolic process
GO:1901565 organonitrogen compound catabolic process
GO:1903034 regulation of response to wounding
GO:1903510 mucopolysaccharide metabolic process
Molecular Function GO:0005041 low-density lipoprotein receptor activity
GO:0005044 scavenger receptor activity
GO:0005539 glycosaminoglycan binding
GO:0005540 hyaluronic acid binding
GO:0015035 protein disulfide oxidoreductase activity
GO:0015036 disulfide oxidoreductase activity
GO:0016667 oxidoreductase activity, acting on a sulfur group of donors
GO:0030169 low-density lipoprotein particle binding
GO:0030228 lipoprotein particle receptor activity
GO:0038024 cargo receptor activity
GO:0071813 lipoprotein particle binding
GO:0071814 protein-lipid complex binding
Cellular Component GO:0009897 external side of plasma membrane
GO:0030139 endocytic vesicle
GO:0030659 cytoplasmic vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0098552 side of membrane
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-2173782: Binding and Uptake of Ligands by Scavenger Receptors
R-HSA-1630316: Glycosaminoglycan metabolism
R-HSA-2142845: Hyaluronan metabolism
R-HSA-2160916: Hyaluronan uptake and degradation
R-HSA-1430728: Metabolism
R-HSA-71387: Metabolism of carbohydrates
R-HSA-3000497: Scavenging by Class H Receptors
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolSTAB2
Namestabilin 2
Aliases DKFZP434E0321; FELL; STAB-2; HARE; FEEL-2; hyaluronic acid receptor for endocytosis; FEEL2; FELE-2; FELL2; F ......
Chromosomal Location12q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between STAB2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolSTAB2
Namestabilin 2
Aliases DKFZP434E0321; FELL; STAB-2; HARE; FEEL-2; hyaluronic acid receptor for endocytosis; FEEL2; FELE-2; FELL2; F ......
Chromosomal Location12q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of STAB2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSTAB2
Namestabilin 2
Aliases DKFZP434E0321; FELL; STAB-2; HARE; FEEL-2; hyaluronic acid receptor for endocytosis; FEEL2; FELE-2; FELL2; F ......
Chromosomal Location12q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of STAB2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0640.693
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1030.836
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1860.639
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.0980.0628
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.680.735
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.6290.506
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2530.672
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0820.926
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3710.7
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.6880.294
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.5990.0595
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.980.02
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of STAB2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141714.3014.30.196
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103200201
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277325.917.88.10.404
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 014021.4-21.41
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275925.916.990.386
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211728.611.816.80.257
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8637.5037.50.209
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131123.118.24.91
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.112.5-1.41
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59022.2-22.20.505
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 382715.83.712.10.224
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.17.71.41
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1614250250.103
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSTAB2
Namestabilin 2
Aliases DKFZP434E0321; FELL; STAB-2; HARE; FEEL-2; hyaluronic acid receptor for endocytosis; FEEL2; FELE-2; FELL2; F ......
Chromosomal Location12q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of STAB2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSTAB2
Namestabilin 2
Aliases DKFZP434E0321; FELL; STAB-2; HARE; FEEL-2; hyaluronic acid receptor for endocytosis; FEEL2; FELE-2; FELL2; F ......
Chromosomal Location12q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of STAB2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by STAB2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSTAB2
Namestabilin 2
Aliases DKFZP434E0321; FELL; STAB-2; HARE; FEEL-2; hyaluronic acid receptor for endocytosis; FEEL2; FELE-2; FELL2; F ......
Chromosomal Location12q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of STAB2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSTAB2
Namestabilin 2
Aliases DKFZP434E0321; FELL; STAB-2; HARE; FEEL-2; hyaluronic acid receptor for endocytosis; FEEL2; FELE-2; FELL2; F ......
Chromosomal Location12q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of STAB2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSTAB2
Namestabilin 2
Aliases DKFZP434E0321; FELL; STAB-2; HARE; FEEL-2; hyaluronic acid receptor for endocytosis; FEEL2; FELE-2; FELL2; F ......
Chromosomal Location12q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between STAB2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSTAB2
Namestabilin 2
Aliases DKFZP434E0321; FELL; STAB-2; HARE; FEEL-2; hyaluronic acid receptor for endocytosis; FEEL2; FELE-2; FELL2; F ......
Chromosomal Location12q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting STAB2 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting STAB2.
ID Name Drug Type Targets #Targets
DB08818Hyaluronic acidSmall MoleculeC1QBP, CD44, HABP2, HABP4, HAPLN1, HAPLN3, HAPLN4, HMMR, ICAM1, IM ......15