Summary | |
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Symbol | STAT2 |
Name | signal transducer and activator of transcription 2, 113kDa |
Aliases | STAT113; signal transducer and activator of transcription 2, 113kD; P113; interferon alpha induced transcrip ...... |
Chromosomal Location | 12q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus Note=Translocated into the nucleus upon activation by IFN-alpha/beta. |
Domain |
PF00017 SH2 domain PF12188 Signal transducer and activator of transcription 2 C terminal PF01017 STAT protein PF02864 STAT protein PF02865 STAT protein |
Function |
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121). |
Biological Process |
GO:0000266 mitochondrial fission GO:0001959 regulation of cytokine-mediated signaling pathway GO:0007259 JAK-STAT cascade GO:0009615 response to virus GO:0010821 regulation of mitochondrion organization GO:0034340 response to type I interferon GO:0045088 regulation of innate immune response GO:0051607 defense response to virus GO:0060337 type I interferon signaling pathway GO:0060338 regulation of type I interferon-mediated signaling pathway GO:0060759 regulation of response to cytokine stimulus GO:0071357 cellular response to type I interferon GO:0090140 regulation of mitochondrial fission GO:0097696 STAT cascade GO:0098542 defense response to other organism |
Molecular Function | - |
Cellular Component | - |
KEGG |
hsa04062 Chemokine signaling pathway hsa04380 Osteoclast differentiation hsa04621 NOD-like receptor signaling pathway hsa04630 Jak-STAT signaling pathway |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-913531: Interferon Signaling R-HSA-909733: Interferon alpha/beta signaling R-HSA-912694: Regulation of IFNA signaling |
Summary | |
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Symbol | STAT2 |
Name | signal transducer and activator of transcription 2, 113kDa |
Aliases | STAT113; signal transducer and activator of transcription 2, 113kD; P113; interferon alpha induced transcrip ...... |
Chromosomal Location | 12q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between STAT2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between STAT2 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | STAT2 |
Name | signal transducer and activator of transcription 2, 113kDa |
Aliases | STAT113; signal transducer and activator of transcription 2, 113kD; P113; interferon alpha induced transcrip ...... |
Chromosomal Location | 12q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of STAT2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | STAT2 |
Name | signal transducer and activator of transcription 2, 113kDa |
Aliases | STAT113; signal transducer and activator of transcription 2, 113kD; P113; interferon alpha induced transcrip ...... |
Chromosomal Location | 12q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of STAT2 in various data sets.
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Points in the above scatter plot represent the mutation difference of STAT2 in various data sets.
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Summary | |
---|---|
Symbol | STAT2 |
Name | signal transducer and activator of transcription 2, 113kDa |
Aliases | STAT113; signal transducer and activator of transcription 2, 113kD; P113; interferon alpha induced transcrip ...... |
Chromosomal Location | 12q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of STAT2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | STAT2 |
Name | signal transducer and activator of transcription 2, 113kDa |
Aliases | STAT113; signal transducer and activator of transcription 2, 113kD; P113; interferon alpha induced transcrip ...... |
Chromosomal Location | 12q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of STAT2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by STAT2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | STAT2 |
Name | signal transducer and activator of transcription 2, 113kDa |
Aliases | STAT113; signal transducer and activator of transcription 2, 113kD; P113; interferon alpha induced transcrip ...... |
Chromosomal Location | 12q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of STAT2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | STAT2 |
Name | signal transducer and activator of transcription 2, 113kDa |
Aliases | STAT113; signal transducer and activator of transcription 2, 113kD; P113; interferon alpha induced transcrip ...... |
Chromosomal Location | 12q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of STAT2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | STAT2 |
Name | signal transducer and activator of transcription 2, 113kDa |
Aliases | STAT113; signal transducer and activator of transcription 2, 113kD; P113; interferon alpha induced transcrip ...... |
Chromosomal Location | 12q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between STAT2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | STAT2 |
Name | signal transducer and activator of transcription 2, 113kDa |
Aliases | STAT113; signal transducer and activator of transcription 2, 113kD; P113; interferon alpha induced transcrip ...... |
Chromosomal Location | 12q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting STAT2 collected from DrugBank database. |
There is no record. |