Browse STAT2

Summary
SymbolSTAT2
Namesignal transducer and activator of transcription 2, 113kDa
Aliases STAT113; signal transducer and activator of transcription 2, 113kD; P113; interferon alpha induced transcrip ......
Chromosomal Location12q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Nucleus Note=Translocated into the nucleus upon activation by IFN-alpha/beta.
Domain PF00017 SH2 domain
PF12188 Signal transducer and activator of transcription 2 C terminal
PF01017 STAT protein
PF02864 STAT protein
PF02865 STAT protein
Function

Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121).

> Gene Ontology
 
Biological Process GO:0000266 mitochondrial fission
GO:0001959 regulation of cytokine-mediated signaling pathway
GO:0007259 JAK-STAT cascade
GO:0009615 response to virus
GO:0010821 regulation of mitochondrion organization
GO:0034340 response to type I interferon
GO:0045088 regulation of innate immune response
GO:0051607 defense response to virus
GO:0060337 type I interferon signaling pathway
GO:0060338 regulation of type I interferon-mediated signaling pathway
GO:0060759 regulation of response to cytokine stimulus
GO:0071357 cellular response to type I interferon
GO:0090140 regulation of mitochondrial fission
GO:0097696 STAT cascade
GO:0098542 defense response to other organism
Molecular Function -
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04062 Chemokine signaling pathway
hsa04380 Osteoclast differentiation
hsa04621 NOD-like receptor signaling pathway
hsa04630 Jak-STAT signaling pathway
Reactome R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-168256: Immune System
R-HSA-913531: Interferon Signaling
R-HSA-909733: Interferon alpha/beta signaling
R-HSA-912694: Regulation of IFNA signaling
Summary
SymbolSTAT2
Namesignal transducer and activator of transcription 2, 113kDa
Aliases STAT113; signal transducer and activator of transcription 2, 113kD; P113; interferon alpha induced transcrip ......
Chromosomal Location12q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between STAT2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between STAT2 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
26404003Lung CacinomaPromote immunity (infiltration)Systemic DLL-1 administration increased T-cell infiltration into tumors and elevated numbers of CD44(+)CD62L(+)CD8(+) memory T cells while decreasing the number of regulatory T cells and limiting tumor vascularization. This treatment was associated with upregulation of Notch and its ligands in tumor-infiltrating T cells enhanced expression of T-bet and phosphorylation of Stat1/2.
24895110melanomaPromote immunity (T cell function); increase the efficacy of immunotherapyHere we show in a syngeneic tumor transplantation model that STAT2 reduces tumor growth.Gene expression analysis revealed a small subset of immunomodulatory genes to be downregulated in tumors established in Stat2(-/-) mice.
Summary
SymbolSTAT2
Namesignal transducer and activator of transcription 2, 113kDa
Aliases STAT113; signal transducer and activator of transcription 2, 113kD; P113; interferon alpha induced transcrip ......
Chromosomal Location12q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of STAT2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 STARS Score: 4.08; FDR: 0.031 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX STARS Score: 4.80; FDR: 0.014 Sensitive to T cell-mediated killing
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolSTAT2
Namesignal transducer and activator of transcription 2, 113kDa
Aliases STAT113; signal transducer and activator of transcription 2, 113kD; P113; interferon alpha induced transcrip ......
Chromosomal Location12q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of STAT2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.240.312
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.5180.815
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0340.984
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2580.446
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1640.95
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3790.911
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0730.877
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.5430.795
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.4060.859
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.2380.537
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.6990.567
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0280.692
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of STAT2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277304.1-4.10.561
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275905.1-5.10.549
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382703.7-3.70.415
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolSTAT2
Namesignal transducer and activator of transcription 2, 113kDa
Aliases STAT113; signal transducer and activator of transcription 2, 113kD; P113; interferon alpha induced transcrip ......
Chromosomal Location12q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of STAT2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSTAT2
Namesignal transducer and activator of transcription 2, 113kDa
Aliases STAT113; signal transducer and activator of transcription 2, 113kD; P113; interferon alpha induced transcrip ......
Chromosomal Location12q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of STAT2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by STAT2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSTAT2
Namesignal transducer and activator of transcription 2, 113kDa
Aliases STAT113; signal transducer and activator of transcription 2, 113kD; P113; interferon alpha induced transcrip ......
Chromosomal Location12q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of STAT2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSTAT2
Namesignal transducer and activator of transcription 2, 113kDa
Aliases STAT113; signal transducer and activator of transcription 2, 113kD; P113; interferon alpha induced transcrip ......
Chromosomal Location12q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of STAT2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSTAT2
Namesignal transducer and activator of transcription 2, 113kDa
Aliases STAT113; signal transducer and activator of transcription 2, 113kD; P113; interferon alpha induced transcrip ......
Chromosomal Location12q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between STAT2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSTAT2
Namesignal transducer and activator of transcription 2, 113kDa
Aliases STAT113; signal transducer and activator of transcription 2, 113kD; P113; interferon alpha induced transcrip ......
Chromosomal Location12q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting STAT2 collected from DrugBank database.
> Drugs from DrugBank database
 

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