Summary | |
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Symbol | STAT3 |
Name | signal transducer and activator of transcription 3 (acute-phase response factor) |
Aliases | APRF; ADMIO; HIES; DNA-binding protein APRF; acute-phase response factor; Signal transducer and activator of ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Nucleus Note=Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1. |
Domain |
PF00017 SH2 domain PF01017 STAT protein PF02864 STAT protein PF02865 STAT protein |
Function |
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity). |
Biological Process |
GO:0001654 eye development GO:0001659 temperature homeostasis GO:0001754 eye photoreceptor cell differentiation GO:0001764 neuron migration GO:0002526 acute inflammatory response GO:0006090 pyruvate metabolic process GO:0006091 generation of precursor metabolites and energy GO:0006096 glycolytic process GO:0006109 regulation of carbohydrate metabolic process GO:0006110 regulation of glycolytic process GO:0006140 regulation of nucleotide metabolic process GO:0006164 purine nucleotide biosynthetic process GO:0006165 nucleoside diphosphate phosphorylation GO:0006417 regulation of translation GO:0006606 protein import into nucleus GO:0006732 coenzyme metabolic process GO:0006733 oxidoreduction coenzyme metabolic process GO:0006754 ATP biosynthetic process GO:0006757 ATP generation from ADP GO:0006839 mitochondrial transport GO:0006913 nucleocytoplasmic transport GO:0006953 acute-phase response GO:0007006 mitochondrial membrane organization GO:0007219 Notch signaling pathway GO:0007259 JAK-STAT cascade GO:0007260 tyrosine phosphorylation of STAT protein GO:0007423 sensory organ development GO:0007568 aging GO:0007631 feeding behavior GO:0008593 regulation of Notch signaling pathway GO:0009116 nucleoside metabolic process GO:0009118 regulation of nucleoside metabolic process GO:0009119 ribonucleoside metabolic process GO:0009123 nucleoside monophosphate metabolic process GO:0009124 nucleoside monophosphate biosynthetic process GO:0009126 purine nucleoside monophosphate metabolic process GO:0009127 purine nucleoside monophosphate biosynthetic process GO:0009132 nucleoside diphosphate metabolic process GO:0009135 purine nucleoside diphosphate metabolic process GO:0009141 nucleoside triphosphate metabolic process GO:0009142 nucleoside triphosphate biosynthetic process GO:0009144 purine nucleoside triphosphate metabolic process GO:0009145 purine nucleoside triphosphate biosynthetic process GO:0009150 purine ribonucleotide metabolic process GO:0009152 purine ribonucleotide biosynthetic process GO:0009156 ribonucleoside monophosphate biosynthetic process GO:0009161 ribonucleoside monophosphate metabolic process GO:0009163 nucleoside biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009167 purine ribonucleoside monophosphate metabolic process GO:0009168 purine ribonucleoside monophosphate biosynthetic process GO:0009179 purine ribonucleoside diphosphate metabolic process GO:0009185 ribonucleoside diphosphate metabolic process GO:0009199 ribonucleoside triphosphate metabolic process GO:0009201 ribonucleoside triphosphate biosynthetic process GO:0009205 purine ribonucleoside triphosphate metabolic process GO:0009206 purine ribonucleoside triphosphate biosynthetic process GO:0009260 ribonucleotide biosynthetic process GO:0009894 regulation of catabolic process GO:0009895 negative regulation of catabolic process GO:0010001 glial cell differentiation GO:0010310 regulation of hydrogen peroxide metabolic process GO:0010608 posttranscriptional regulation of gene expression GO:0010675 regulation of cellular carbohydrate metabolic process GO:0010677 negative regulation of cellular carbohydrate metabolic process GO:0010721 negative regulation of cell development GO:0010727 negative regulation of hydrogen peroxide metabolic process GO:0010728 regulation of hydrogen peroxide biosynthetic process GO:0010730 negative regulation of hydrogen peroxide biosynthetic process GO:0010950 positive regulation of endopeptidase activity GO:0010952 positive regulation of peptidase activity GO:0016052 carbohydrate catabolic process GO:0016441 posttranscriptional gene silencing GO:0016458 gene silencing GO:0017038 protein import GO:0017148 negative regulation of translation GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0019362 pyridine nucleotide metabolic process GO:0019827 stem cell population maintenance GO:0030336 negative regulation of cell migration GO:0030522 intracellular receptor signaling pathway GO:0030808 regulation of nucleotide biosynthetic process GO:0030810 positive regulation of nucleotide biosynthetic process GO:0031047 gene silencing by RNA GO:0032355 response to estradiol GO:0033210 leptin-mediated signaling pathway GO:0033500 carbohydrate homeostasis GO:0034248 regulation of cellular amide metabolic process GO:0034249 negative regulation of cellular amide metabolic process GO:0034504 protein localization to nucleus GO:0035019 somatic stem cell population maintenance GO:0035194 posttranscriptional gene silencing by RNA GO:0035195 gene silencing by miRNA GO:0035264 multicellular organism growth GO:0035278 miRNA mediated inhibition of translation GO:0040013 negative regulation of locomotion GO:0040014 regulation of multicellular organism growth GO:0040029 regulation of gene expression, epigenetic GO:0040033 negative regulation of translation, ncRNA-mediated GO:0042063 gliogenesis GO:0042278 purine nucleoside metabolic process GO:0042326 negative regulation of phosphorylation GO:0042451 purine nucleoside biosynthetic process GO:0042455 ribonucleoside biosynthetic process GO:0042493 response to drug GO:0042503 tyrosine phosphorylation of Stat3 protein GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0042593 glucose homeostasis GO:0042743 hydrogen peroxide metabolic process GO:0042755 eating behavior GO:0043434 response to peptide hormone GO:0043467 regulation of generation of precursor metabolites and energy GO:0043470 regulation of carbohydrate catabolic process GO:0044262 cellular carbohydrate metabolic process GO:0044320 cellular response to leptin stimulus GO:0044321 response to leptin GO:0044723 single-organism carbohydrate metabolic process GO:0044724 single-organism carbohydrate catabolic process GO:0044744 protein targeting to nucleus GO:0045471 response to ethanol GO:0045747 positive regulation of Notch signaling pathway GO:0045820 negative regulation of glycolytic process GO:0045862 positive regulation of proteolysis GO:0045912 negative regulation of carbohydrate metabolic process GO:0045974 regulation of translation, ncRNA-mediated GO:0045978 negative regulation of nucleoside metabolic process GO:0045979 positive regulation of nucleoside metabolic process GO:0045980 negative regulation of nucleotide metabolic process GO:0045981 positive regulation of nucleotide metabolic process GO:0046031 ADP metabolic process GO:0046034 ATP metabolic process GO:0046128 purine ribonucleoside metabolic process GO:0046129 purine ribonucleoside biosynthetic process GO:0046390 ribose phosphate biosynthetic process GO:0046425 regulation of JAK-STAT cascade GO:0046427 positive regulation of JAK-STAT cascade GO:0046496 nicotinamide nucleotide metabolic process GO:0046530 photoreceptor cell differentiation GO:0046902 regulation of mitochondrial membrane permeability GO:0046939 nucleotide phosphorylation GO:0048592 eye morphogenesis GO:0048638 regulation of developmental growth GO:0048708 astrocyte differentiation GO:0048863 stem cell differentiation GO:0048871 multicellular organismal homeostasis GO:0050665 hydrogen peroxide biosynthetic process GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050768 negative regulation of neurogenesis GO:0050795 regulation of behavior GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051186 cofactor metabolic process GO:0051193 regulation of cofactor metabolic process GO:0051195 negative regulation of cofactor metabolic process GO:0051196 regulation of coenzyme metabolic process GO:0051198 negative regulation of coenzyme metabolic process GO:0051271 negative regulation of cellular component movement GO:0051961 negative regulation of nervous system development GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0060019 radial glial cell differentiation GO:0060147 regulation of posttranscriptional gene silencing GO:0060148 positive regulation of posttranscriptional gene silencing GO:0060259 regulation of feeding behavior GO:0060396 growth hormone receptor signaling pathway GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060416 response to growth hormone GO:0060964 regulation of gene silencing by miRNA GO:0060966 regulation of gene silencing by RNA GO:0060968 regulation of gene silencing GO:0061614 pri-miRNA transcription from RNA polymerase II promoter GO:0070102 interleukin-6-mediated signaling pathway GO:0070741 response to interleukin-6 GO:0070997 neuron death GO:0071354 cellular response to interleukin-6 GO:0071375 cellular response to peptide hormone stimulus GO:0071378 cellular response to growth hormone stimulus GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0072522 purine-containing compound biosynthetic process GO:0072524 pyridine-containing compound metabolic process GO:0072593 reactive oxygen species metabolic process GO:0090559 regulation of membrane permeability GO:0090596 sensory organ morphogenesis GO:0097009 energy homeostasis GO:0097305 response to alcohol GO:0097696 STAT cascade GO:0098727 maintenance of cell number GO:1900371 regulation of purine nucleotide biosynthetic process GO:1900373 positive regulation of purine nucleotide biosynthetic process GO:1900542 regulation of purine nucleotide metabolic process GO:1900543 negative regulation of purine nucleotide metabolic process GO:1900544 positive regulation of purine nucleotide metabolic process GO:1901214 regulation of neuron death GO:1901215 negative regulation of neuron death GO:1901293 nucleoside phosphate biosynthetic process GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1901657 glycosyl compound metabolic process GO:1901659 glycosyl compound biosynthetic process GO:1902593 single-organism nuclear import GO:1902728 positive regulation of growth factor dependent skeletal muscle satellite cell proliferation GO:1902893 regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1903409 reactive oxygen species biosynthetic process GO:1903426 regulation of reactive oxygen species biosynthetic process GO:1903427 negative regulation of reactive oxygen species biosynthetic process GO:1903578 regulation of ATP metabolic process GO:1903579 negative regulation of ATP metabolic process GO:1903580 positive regulation of ATP metabolic process GO:1904683 regulation of metalloendopeptidase activity GO:1904685 positive regulation of metalloendopeptidase activity GO:1904892 regulation of STAT cascade GO:1904894 positive regulation of STAT cascade GO:1905048 regulation of metallopeptidase activity GO:1905050 positive regulation of metallopeptidase activity GO:2000146 negative regulation of cell motility GO:2000377 regulation of reactive oxygen species metabolic process GO:2000378 negative regulation of reactive oxygen species metabolic process GO:2000637 positive regulation of gene silencing by miRNA GO:2000736 regulation of stem cell differentiation GO:2000737 negative regulation of stem cell differentiation GO:2001169 regulation of ATP biosynthetic process GO:2001171 positive regulation of ATP biosynthetic process GO:2001222 regulation of neuron migration GO:2001223 negative regulation of neuron migration |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001085 RNA polymerase II transcription factor binding GO:0001103 RNA polymerase II repressing transcription factor binding GO:0001159 core promoter proximal region DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0001664 G-protein coupled receptor binding GO:0003682 chromatin binding GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0005126 cytokine receptor binding GO:0008134 transcription factor binding GO:0019902 phosphatase binding GO:0019903 protein phosphatase binding GO:0031490 chromatin DNA binding GO:0031730 CCR5 chemokine receptor binding GO:0035257 nuclear hormone receptor binding GO:0035258 steroid hormone receptor binding GO:0035259 glucocorticoid receptor binding GO:0042379 chemokine receptor binding GO:0043566 structure-specific DNA binding GO:0048020 CCR chemokine receptor binding GO:0051427 hormone receptor binding GO:0070491 repressing transcription factor binding GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding |
Cellular Component |
GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0005667 transcription factor complex GO:0005743 mitochondrial inner membrane GO:0044454 nuclear chromosome part GO:0044798 nuclear transcription factor complex GO:0090575 RNA polymerase II transcription factor complex |
KEGG |
hsa04062 Chemokine signaling pathway hsa04066 HIF-1 signaling pathway hsa04068 FoxO signaling pathway hsa04550 Signaling pathways regulating pluripotency of stem cells hsa04630 Jak-STAT signaling pathway hsa04917 Prolactin signaling pathway hsa04920 Adipocytokine signaling pathway |
Reactome |
R-HSA-390471: Association of TriC/CCT with target proteins during biosynthesis R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-390466: Chaperonin-mediated protein folding R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-186763: Downstream signal transduction R-HSA-1839124: FGFR1 mutant receptor activation R-HSA-982772: Growth hormone receptor signaling R-HSA-168256: Immune System R-HSA-6783783: Interleukin-10 signaling R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-6783589: Interleukin-6 family signaling R-HSA-1059683: Interleukin-6 signaling R-HSA-8875791: MET activates STAT3 R-HSA-392499: Metabolism of proteins R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-2892247: POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-8849474: PTK6 Activates STAT3 R-HSA-391251: Protein folding R-HSA-2559582: Senescence-Associated Secretory Phenotype (SASP) R-HSA-162582: Signal Transduction R-HSA-1226099: Signaling by FGFR in disease R-HSA-5655302: Signaling by FGFR1 in disease R-HSA-449147: Signaling by Interleukins R-HSA-2586552: Signaling by Leptin R-HSA-6806834: Signaling by MET R-HSA-186797: Signaling by PDGF R-HSA-8848021: Signaling by PTK6 R-HSA-1433557: Signaling by SCF-KIT R-HSA-1839117: Signaling by cytosolic FGFR1 fusion mutants R-HSA-166520: Signalling by NGF R-HSA-198745: Signalling to STAT3 R-HSA-452723: Transcriptional regulation of pluripotent stem cells |
Summary | |
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Symbol | STAT3 |
Name | signal transducer and activator of transcription 3 (acute-phase response factor) |
Aliases | APRF; ADMIO; HIES; DNA-binding protein APRF; acute-phase response factor; Signal transducer and activator of ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between STAT3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between STAT3 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | STAT3 |
Name | signal transducer and activator of transcription 3 (acute-phase response factor) |
Aliases | APRF; ADMIO; HIES; DNA-binding protein APRF; acute-phase response factor; Signal transducer and activator of ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of STAT3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | STAT3 |
Name | signal transducer and activator of transcription 3 (acute-phase response factor) |
Aliases | APRF; ADMIO; HIES; DNA-binding protein APRF; acute-phase response factor; Signal transducer and activator of ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of STAT3 in various data sets.
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Points in the above scatter plot represent the mutation difference of STAT3 in various data sets.
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Summary | |
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Symbol | STAT3 |
Name | signal transducer and activator of transcription 3 (acute-phase response factor) |
Aliases | APRF; ADMIO; HIES; DNA-binding protein APRF; acute-phase response factor; Signal transducer and activator of ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of STAT3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | STAT3 |
Name | signal transducer and activator of transcription 3 (acute-phase response factor) |
Aliases | APRF; ADMIO; HIES; DNA-binding protein APRF; acute-phase response factor; Signal transducer and activator of ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of STAT3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by STAT3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | STAT3 |
Name | signal transducer and activator of transcription 3 (acute-phase response factor) |
Aliases | APRF; ADMIO; HIES; DNA-binding protein APRF; acute-phase response factor; Signal transducer and activator of ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of STAT3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | STAT3 |
Name | signal transducer and activator of transcription 3 (acute-phase response factor) |
Aliases | APRF; ADMIO; HIES; DNA-binding protein APRF; acute-phase response factor; Signal transducer and activator of ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of STAT3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | STAT3 |
Name | signal transducer and activator of transcription 3 (acute-phase response factor) |
Aliases | APRF; ADMIO; HIES; DNA-binding protein APRF; acute-phase response factor; Signal transducer and activator of ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between STAT3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | STAT3 |
Name | signal transducer and activator of transcription 3 (acute-phase response factor) |
Aliases | APRF; ADMIO; HIES; DNA-binding protein APRF; acute-phase response factor; Signal transducer and activator of ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting STAT3 collected from DrugBank database. |
Details on drugs targeting STAT3.
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