Summary | |
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Symbol | STAT6 |
Name | signal transducer and activator of transcription 6, interleukin-4 induced |
Aliases | D12S1644; IL-4-STAT; IL-4-STATB; STAT6C; STAT, interleukin4-induced; transcription factor IL-4 STAT; IL-4 St ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation. |
Domain |
PF00017 SH2 domain PF14596 STAT6 C-terminal PF01017 STAT protein PF02864 STAT protein PF02865 STAT protein |
Function |
Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. |
Biological Process |
GO:0000018 regulation of DNA recombination GO:0000302 response to reactive oxygen species GO:0001819 positive regulation of cytokine production GO:0002200 somatic diversification of immune receptors GO:0002204 somatic recombination of immunoglobulin genes involved in immune response GO:0002208 somatic diversification of immunoglobulins involved in immune response GO:0002250 adaptive immune response GO:0002263 cell activation involved in immune response GO:0002285 lymphocyte activation involved in immune response GO:0002286 T cell activation involved in immune response GO:0002287 alpha-beta T cell activation involved in immune response GO:0002292 T cell differentiation involved in immune response GO:0002293 alpha-beta T cell differentiation involved in immune response GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response GO:0002295 T-helper cell lineage commitment GO:0002296 T-helper 1 cell lineage commitment GO:0002312 B cell activation involved in immune response GO:0002360 T cell lineage commitment GO:0002363 alpha-beta T cell lineage commitment GO:0002366 leukocyte activation involved in immune response GO:0002377 immunoglobulin production GO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002440 production of molecular mediator of immune response GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002521 leukocyte differentiation GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus GO:0002637 regulation of immunoglobulin production GO:0002639 positive regulation of immunoglobulin production GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002700 regulation of production of molecular mediator of immune response GO:0002702 positive regulation of production of molecular mediator of immune response GO:0002703 regulation of leukocyte mediated immunity GO:0002705 positive regulation of leukocyte mediated immunity GO:0002706 regulation of lymphocyte mediated immunity GO:0002708 positive regulation of lymphocyte mediated immunity GO:0002712 regulation of B cell mediated immunity GO:0002714 positive regulation of B cell mediated immunity GO:0002819 regulation of adaptive immune response GO:0002821 positive regulation of adaptive immune response GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002828 regulation of type 2 immune response GO:0002829 negative regulation of type 2 immune response GO:0002889 regulation of immunoglobulin mediated immune response GO:0002891 positive regulation of immunoglobulin mediated immune response GO:0006310 DNA recombination GO:0006979 response to oxidative stress GO:0007159 leukocyte cell-cell adhesion GO:0010035 response to inorganic substance GO:0016064 immunoglobulin mediated immune response GO:0016444 somatic cell DNA recombination GO:0016445 somatic diversification of immunoglobulins GO:0016447 somatic recombination of immunoglobulin gene segments GO:0019724 B cell mediated immunity GO:0022612 gland morphogenesis GO:0030098 lymphocyte differentiation GO:0030217 T cell differentiation GO:0030879 mammary gland development GO:0032479 regulation of type I interferon production GO:0032481 positive regulation of type I interferon production GO:0032606 type I interferon production GO:0033598 mammary gland epithelial cell proliferation GO:0034599 cellular response to oxidative stress GO:0034614 cellular response to reactive oxygen species GO:0035710 CD4-positive, alpha-beta T cell activation GO:0035771 interleukin-4-mediated signaling pathway GO:0042088 T-helper 1 type immune response GO:0042092 type 2 immune response GO:0042093 T-helper cell differentiation GO:0042110 T cell activation GO:0042113 B cell activation GO:0042542 response to hydrogen peroxide GO:0043367 CD4-positive, alpha-beta T cell differentiation GO:0043368 positive T cell selection GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment GO:0043373 CD4-positive, alpha-beta T cell lineage commitment GO:0045058 T cell selection GO:0045063 T-helper 1 cell differentiation GO:0045165 cell fate commitment GO:0045190 isotype switching GO:0045191 regulation of isotype switching GO:0045830 positive regulation of isotype switching GO:0045911 positive regulation of DNA recombination GO:0046631 alpha-beta T cell activation GO:0046632 alpha-beta T cell differentiation GO:0048289 isotype switching to IgE isotypes GO:0048293 regulation of isotype switching to IgE isotypes GO:0048295 positive regulation of isotype switching to IgE isotypes GO:0048732 gland development GO:0050673 epithelial cell proliferation GO:0050777 negative regulation of immune response GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050871 positive regulation of B cell activation GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0060443 mammary gland morphogenesis GO:0061180 mammary gland epithelium development GO:0070301 cellular response to hydrogen peroxide GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070670 response to interleukin-4 GO:0071353 cellular response to interleukin-4 GO:0071593 lymphocyte aggregation GO:1902170 cellular response to reactive nitrogen species |
Molecular Function |
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding GO:0019902 phosphatase binding GO:0019903 protein phosphatase binding |
Cellular Component |
GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0044454 nuclear chromosome part GO:0045121 membrane raft GO:0098589 membrane region GO:0098857 membrane microdomain |
KEGG |
hsa04630 Jak-STAT signaling pathway |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-1834949: Cytosolic sensors of pathogen-associated DNA R-HSA-186763: Downstream signal transduction R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-3249367: STAT6-mediated induction of chemokines R-HSA-1834941: STING mediated induction of host immune responses R-HSA-162582: Signal Transduction R-HSA-449147: Signaling by Interleukins R-HSA-186797: Signaling by PDGF |
Summary | |
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Symbol | STAT6 |
Name | signal transducer and activator of transcription 6, interleukin-4 induced |
Aliases | D12S1644; IL-4-STAT; IL-4-STATB; STAT6C; STAT, interleukin4-induced; transcription factor IL-4 STAT; IL-4 St ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between STAT6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between STAT6 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | STAT6 |
Name | signal transducer and activator of transcription 6, interleukin-4 induced |
Aliases | D12S1644; IL-4-STAT; IL-4-STATB; STAT6C; STAT, interleukin4-induced; transcription factor IL-4 STAT; IL-4 St ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of STAT6 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | STAT6 |
Name | signal transducer and activator of transcription 6, interleukin-4 induced |
Aliases | D12S1644; IL-4-STAT; IL-4-STATB; STAT6C; STAT, interleukin4-induced; transcription factor IL-4 STAT; IL-4 St ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of STAT6 in various data sets.
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Points in the above scatter plot represent the mutation difference of STAT6 in various data sets.
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Summary | |
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Symbol | STAT6 |
Name | signal transducer and activator of transcription 6, interleukin-4 induced |
Aliases | D12S1644; IL-4-STAT; IL-4-STATB; STAT6C; STAT, interleukin4-induced; transcription factor IL-4 STAT; IL-4 St ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of STAT6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | STAT6 |
Name | signal transducer and activator of transcription 6, interleukin-4 induced |
Aliases | D12S1644; IL-4-STAT; IL-4-STATB; STAT6C; STAT, interleukin4-induced; transcription factor IL-4 STAT; IL-4 St ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of STAT6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by STAT6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | STAT6 |
Name | signal transducer and activator of transcription 6, interleukin-4 induced |
Aliases | D12S1644; IL-4-STAT; IL-4-STATB; STAT6C; STAT, interleukin4-induced; transcription factor IL-4 STAT; IL-4 St ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of STAT6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | STAT6 |
Name | signal transducer and activator of transcription 6, interleukin-4 induced |
Aliases | D12S1644; IL-4-STAT; IL-4-STATB; STAT6C; STAT, interleukin4-induced; transcription factor IL-4 STAT; IL-4 St ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of STAT6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | STAT6 |
Name | signal transducer and activator of transcription 6, interleukin-4 induced |
Aliases | D12S1644; IL-4-STAT; IL-4-STATB; STAT6C; STAT, interleukin4-induced; transcription factor IL-4 STAT; IL-4 St ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between STAT6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | STAT6 |
Name | signal transducer and activator of transcription 6, interleukin-4 induced |
Aliases | D12S1644; IL-4-STAT; IL-4-STATB; STAT6C; STAT, interleukin4-induced; transcription factor IL-4 STAT; IL-4 St ...... |
Chromosomal Location | 12q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting STAT6 collected from DrugBank database. |
There is no record. |