Summary | |
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Symbol | STC2 |
Name | stanniocalcin 2 |
Aliases | STC-2; STCRP; STC-related protein; stanniocalcin-related protein; Stanniocalcin-2 |
Chromosomal Location | 5q35.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain |
PF03298 Stanniocalcin family |
Function |
Has an anti-hypocalcemic action on calcium and phosphate homeostasis. |
Biological Process |
GO:0001666 response to hypoxia GO:0001890 placenta development GO:0001893 maternal placenta development GO:0002115 store-operated calcium entry GO:0006816 calcium ion transport GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0006979 response to oxidative stress GO:0006986 response to unfolded protein GO:0007565 female pregnancy GO:0007566 embryo implantation GO:0007584 response to nutrient GO:0009991 response to extracellular stimulus GO:0010817 regulation of hormone levels GO:0010959 regulation of metal ion transport GO:0030968 endoplasmic reticulum unfolded protein response GO:0031667 response to nutrient levels GO:0032350 regulation of hormone metabolic process GO:0033273 response to vitamin GO:0033280 response to vitamin D GO:0034620 cellular response to unfolded protein GO:0034976 response to endoplasmic reticulum stress GO:0035264 multicellular organism growth GO:0035966 response to topologically incorrect protein GO:0035967 cellular response to topologically incorrect protein GO:0036293 response to decreased oxygen levels GO:0036294 cellular response to decreased oxygen levels GO:0040014 regulation of multicellular organism growth GO:0040015 negative regulation of multicellular organism growth GO:0042445 hormone metabolic process GO:0042446 hormone biosynthetic process GO:0043434 response to peptide hormone GO:0044706 multi-multicellular organism process GO:0045926 negative regulation of growth GO:0046697 decidualization GO:0046885 regulation of hormone biosynthetic process GO:0048608 reproductive structure development GO:0048638 regulation of developmental growth GO:0048640 negative regulation of developmental growth GO:0051924 regulation of calcium ion transport GO:0055074 calcium ion homeostasis GO:0060135 maternal process involved in female pregnancy GO:0061458 reproductive system development GO:0070482 response to oxygen levels GO:0070838 divalent metal ion transport GO:0071453 cellular response to oxygen levels GO:0071456 cellular response to hypoxia GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072511 divalent inorganic cation transport GO:1901652 response to peptide GO:2001256 regulation of store-operated calcium entry |
Molecular Function |
GO:0005179 hormone activity GO:0020037 heme binding GO:0046906 tetrapyrrole binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | STC2 |
Name | stanniocalcin 2 |
Aliases | STC-2; STCRP; STC-related protein; stanniocalcin-related protein; Stanniocalcin-2 |
Chromosomal Location | 5q35.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between STC2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | STC2 |
Name | stanniocalcin 2 |
Aliases | STC-2; STCRP; STC-related protein; stanniocalcin-related protein; Stanniocalcin-2 |
Chromosomal Location | 5q35.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of STC2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | STC2 |
Name | stanniocalcin 2 |
Aliases | STC-2; STCRP; STC-related protein; stanniocalcin-related protein; Stanniocalcin-2 |
Chromosomal Location | 5q35.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of STC2 in various data sets.
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Points in the above scatter plot represent the mutation difference of STC2 in various data sets.
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Summary | |
---|---|
Symbol | STC2 |
Name | stanniocalcin 2 |
Aliases | STC-2; STCRP; STC-related protein; stanniocalcin-related protein; Stanniocalcin-2 |
Chromosomal Location | 5q35.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of STC2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | STC2 |
Name | stanniocalcin 2 |
Aliases | STC-2; STCRP; STC-related protein; stanniocalcin-related protein; Stanniocalcin-2 |
Chromosomal Location | 5q35.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of STC2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by STC2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | STC2 |
Name | stanniocalcin 2 |
Aliases | STC-2; STCRP; STC-related protein; stanniocalcin-related protein; Stanniocalcin-2 |
Chromosomal Location | 5q35.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of STC2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | STC2 |
Name | stanniocalcin 2 |
Aliases | STC-2; STCRP; STC-related protein; stanniocalcin-related protein; Stanniocalcin-2 |
Chromosomal Location | 5q35.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of STC2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | STC2 |
Name | stanniocalcin 2 |
Aliases | STC-2; STCRP; STC-related protein; stanniocalcin-related protein; Stanniocalcin-2 |
Chromosomal Location | 5q35.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between STC2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |