Browse STK24

Summary
SymbolSTK24
Nameserine/threonine kinase 24
Aliases MST-3; MST3; MST3B; STE20; STE20-like kinase 3; sterile 20-like kinase 3; serine/threonine kinase 24 (Ste20, ......
Chromosomal Location13q31.2-q32.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm. Nucleus. Membrane. Note=The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane.
Domain PF00069 Protein kinase domain
Function

Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.

> Gene Ontology
 
Biological Process GO:0000302 response to reactive oxygen species
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0006979 response to oxidative stress
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010035 response to inorganic substance
GO:0010975 regulation of neuron projection development
GO:0030336 negative regulation of cell migration
GO:0031099 regeneration
GO:0031102 neuron projection regeneration
GO:0031103 axon regeneration
GO:0034599 cellular response to oxidative stress
GO:0036473 cell death in response to oxidative stress
GO:0040013 negative regulation of locomotion
GO:0042542 response to hydrogen peroxide
GO:0046777 protein autophosphorylation
GO:0048678 response to axon injury
GO:0048679 regulation of axon regeneration
GO:0051271 negative regulation of cellular component movement
GO:0061564 axon development
GO:0070570 regulation of neuron projection regeneration
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097194 execution phase of apoptosis
GO:1903034 regulation of response to wounding
GO:2000146 negative regulation of cell motility
Molecular Function GO:0004674 protein serine/threonine kinase activity
GO:0004702 receptor signaling protein serine/threonine kinase activity
GO:0005057 receptor signaling protein activity
GO:0045296 cadherin binding
GO:0050839 cell adhesion molecule binding
GO:0098631 protein binding involved in cell adhesion
GO:0098632 protein binding involved in cell-cell adhesion
GO:0098641 cadherin binding involved in cell-cell adhesion
Cellular Component GO:0005913 cell-cell adherens junction
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-109581: Apoptosis
R-HSA-111465: Apoptotic cleavage of cellular proteins
R-HSA-75153: Apoptotic execution phase
R-HSA-5357801: Programmed Cell Death
Summary
SymbolSTK24
Nameserine/threonine kinase 24
Aliases MST-3; MST3; MST3B; STE20; STE20-like kinase 3; sterile 20-like kinase 3; serine/threonine kinase 24 (Ste20, ......
Chromosomal Location13q31.2-q32.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between STK24 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolSTK24
Nameserine/threonine kinase 24
Aliases MST-3; MST3; MST3B; STE20; STE20-like kinase 3; sterile 20-like kinase 3; serine/threonine kinase 24 (Ste20, ......
Chromosomal Location13q31.2-q32.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of STK24 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSTK24
Nameserine/threonine kinase 24
Aliases MST-3; MST3; MST3B; STE20; STE20-like kinase 3; sterile 20-like kinase 3; serine/threonine kinase 24 (Ste20, ......
Chromosomal Location13q31.2-q32.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of STK24 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.6190.0147
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.6880.768
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.5710.734
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.5770.216
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.5070.834
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.6720.837
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1410.747
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0220.991
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2930.897
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.070.966
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.4670.851
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1090.218
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of STK24 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.41.460.177
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.41.75.70.231
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.4015.40.482
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221307.7-7.70.371
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSTK24
Nameserine/threonine kinase 24
Aliases MST-3; MST3; MST3B; STE20; STE20-like kinase 3; sterile 20-like kinase 3; serine/threonine kinase 24 (Ste20, ......
Chromosomal Location13q31.2-q32.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of STK24. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSTK24
Nameserine/threonine kinase 24
Aliases MST-3; MST3; MST3B; STE20; STE20-like kinase 3; sterile 20-like kinase 3; serine/threonine kinase 24 (Ste20, ......
Chromosomal Location13q31.2-q32.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of STK24. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by STK24.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSTK24
Nameserine/threonine kinase 24
Aliases MST-3; MST3; MST3B; STE20; STE20-like kinase 3; sterile 20-like kinase 3; serine/threonine kinase 24 (Ste20, ......
Chromosomal Location13q31.2-q32.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of STK24. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSTK24
Nameserine/threonine kinase 24
Aliases MST-3; MST3; MST3B; STE20; STE20-like kinase 3; sterile 20-like kinase 3; serine/threonine kinase 24 (Ste20, ......
Chromosomal Location13q31.2-q32.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of STK24 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSTK24
Nameserine/threonine kinase 24
Aliases MST-3; MST3; MST3B; STE20; STE20-like kinase 3; sterile 20-like kinase 3; serine/threonine kinase 24 (Ste20, ......
Chromosomal Location13q31.2-q32.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between STK24 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSTK24
Nameserine/threonine kinase 24
Aliases MST-3; MST3; MST3B; STE20; STE20-like kinase 3; sterile 20-like kinase 3; serine/threonine kinase 24 (Ste20, ......
Chromosomal Location13q31.2-q32.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting STK24 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.