Summary | |
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Symbol | STK38 |
Name | serine/threonine kinase 38 |
Aliases | NDR1 protein kinase; Ndr Ser/Thr kinase-like protein; nuclear Dbf2-related kinase 1; Serine/threonine-protei ...... |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. Cytoplasm. |
Domain |
PF00069 Protein kinase domain PF00433 Protein kinase C terminal domain |
Function |
Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2. |
Biological Process |
GO:0001933 negative regulation of protein phosphorylation GO:0006469 negative regulation of protein kinase activity GO:0018105 peptidyl-serine phosphorylation GO:0018209 peptidyl-serine modification GO:0033673 negative regulation of kinase activity GO:0042326 negative regulation of phosphorylation GO:0043405 regulation of MAP kinase activity GO:0043407 negative regulation of MAP kinase activity GO:0043409 negative regulation of MAPK cascade GO:0051348 negative regulation of transferase activity GO:0071900 regulation of protein serine/threonine kinase activity GO:0071901 negative regulation of protein serine/threonine kinase activity GO:1902532 negative regulation of intracellular signal transduction |
Molecular Function |
GO:0000287 magnesium ion binding GO:0004674 protein serine/threonine kinase activity GO:0031435 mitogen-activated protein kinase kinase kinase binding GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0005913 cell-cell adherens junction GO:0034708 methyltransferase complex GO:0035097 histone methyltransferase complex GO:0070688 MLL5-L complex |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | STK38 |
Name | serine/threonine kinase 38 |
Aliases | NDR1 protein kinase; Ndr Ser/Thr kinase-like protein; nuclear Dbf2-related kinase 1; Serine/threonine-protei ...... |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between STK38 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | STK38 |
Name | serine/threonine kinase 38 |
Aliases | NDR1 protein kinase; Ndr Ser/Thr kinase-like protein; nuclear Dbf2-related kinase 1; Serine/threonine-protei ...... |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of STK38 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | STK38 |
Name | serine/threonine kinase 38 |
Aliases | NDR1 protein kinase; Ndr Ser/Thr kinase-like protein; nuclear Dbf2-related kinase 1; Serine/threonine-protei ...... |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of STK38 in various data sets.
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Points in the above scatter plot represent the mutation difference of STK38 in various data sets.
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Summary | |
---|---|
Symbol | STK38 |
Name | serine/threonine kinase 38 |
Aliases | NDR1 protein kinase; Ndr Ser/Thr kinase-like protein; nuclear Dbf2-related kinase 1; Serine/threonine-protei ...... |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of STK38. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | STK38 |
Name | serine/threonine kinase 38 |
Aliases | NDR1 protein kinase; Ndr Ser/Thr kinase-like protein; nuclear Dbf2-related kinase 1; Serine/threonine-protei ...... |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of STK38. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by STK38. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | STK38 |
Name | serine/threonine kinase 38 |
Aliases | NDR1 protein kinase; Ndr Ser/Thr kinase-like protein; nuclear Dbf2-related kinase 1; Serine/threonine-protei ...... |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of STK38. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | STK38 |
Name | serine/threonine kinase 38 |
Aliases | NDR1 protein kinase; Ndr Ser/Thr kinase-like protein; nuclear Dbf2-related kinase 1; Serine/threonine-protei ...... |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of STK38 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | STK38 |
Name | serine/threonine kinase 38 |
Aliases | NDR1 protein kinase; Ndr Ser/Thr kinase-like protein; nuclear Dbf2-related kinase 1; Serine/threonine-protei ...... |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between STK38 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | STK38 |
Name | serine/threonine kinase 38 |
Aliases | NDR1 protein kinase; Ndr Ser/Thr kinase-like protein; nuclear Dbf2-related kinase 1; Serine/threonine-protei ...... |
Chromosomal Location | 6p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting STK38 collected from DrugBank database. |
There is no record. |