Summary | |
---|---|
Symbol | STK40 |
Name | serine/threonine kinase 40 |
Aliases | MGC4796; SgK495; SHIK; SINK-homologous serine/threonine-protein kinase; Ser/Thr-like kinase; sugen kinase 49 ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Cytoplasm |
Domain |
PF00069 Protein kinase domain |
Function |
May be a negative regulator of NF-kappa-B and p53-mediated gene transcription. |
Biological Process |
GO:0003016 respiratory system process GO:0005976 polysaccharide metabolic process GO:0005977 glycogen metabolic process GO:0006073 cellular glucan metabolic process GO:0006091 generation of precursor metabolites and energy GO:0006112 energy reserve metabolic process GO:0007585 respiratory gaseous exchange GO:0015980 energy derivation by oxidation of organic compounds GO:0030323 respiratory tube development GO:0030324 lung development GO:0035264 multicellular organism growth GO:0044042 glucan metabolic process GO:0044262 cellular carbohydrate metabolic process GO:0044264 cellular polysaccharide metabolic process GO:0044723 single-organism carbohydrate metabolic process GO:0048286 lung alveolus development GO:0060425 lung morphogenesis GO:0060541 respiratory system development |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | STK40 |
Name | serine/threonine kinase 40 |
Aliases | MGC4796; SgK495; SHIK; SINK-homologous serine/threonine-protein kinase; Ser/Thr-like kinase; sugen kinase 49 ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between STK40 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | STK40 |
Name | serine/threonine kinase 40 |
Aliases | MGC4796; SgK495; SHIK; SINK-homologous serine/threonine-protein kinase; Ser/Thr-like kinase; sugen kinase 49 ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of STK40 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | STK40 |
Name | serine/threonine kinase 40 |
Aliases | MGC4796; SgK495; SHIK; SINK-homologous serine/threonine-protein kinase; Ser/Thr-like kinase; sugen kinase 49 ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of STK40 in various data sets.
|
Points in the above scatter plot represent the mutation difference of STK40 in various data sets.
|
Summary | |
---|---|
Symbol | STK40 |
Name | serine/threonine kinase 40 |
Aliases | MGC4796; SgK495; SHIK; SINK-homologous serine/threonine-protein kinase; Ser/Thr-like kinase; sugen kinase 49 ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of STK40. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | STK40 |
Name | serine/threonine kinase 40 |
Aliases | MGC4796; SgK495; SHIK; SINK-homologous serine/threonine-protein kinase; Ser/Thr-like kinase; sugen kinase 49 ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of STK40. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by STK40. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | STK40 |
Name | serine/threonine kinase 40 |
Aliases | MGC4796; SgK495; SHIK; SINK-homologous serine/threonine-protein kinase; Ser/Thr-like kinase; sugen kinase 49 ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of STK40. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | STK40 |
Name | serine/threonine kinase 40 |
Aliases | MGC4796; SgK495; SHIK; SINK-homologous serine/threonine-protein kinase; Ser/Thr-like kinase; sugen kinase 49 ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of STK40 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | STK40 |
Name | serine/threonine kinase 40 |
Aliases | MGC4796; SgK495; SHIK; SINK-homologous serine/threonine-protein kinase; Ser/Thr-like kinase; sugen kinase 49 ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between STK40 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | STK40 |
Name | serine/threonine kinase 40 |
Aliases | MGC4796; SgK495; SHIK; SINK-homologous serine/threonine-protein kinase; Ser/Thr-like kinase; sugen kinase 49 ...... |
Chromosomal Location | 1p34.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting STK40 collected from DrugBank database. |
There is no record. |