Browse STK40

Summary
SymbolSTK40
Nameserine/threonine kinase 40
Aliases MGC4796; SgK495; SHIK; SINK-homologous serine/threonine-protein kinase; Ser/Thr-like kinase; sugen kinase 49 ......
Chromosomal Location1p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Cytoplasm
Domain PF00069 Protein kinase domain
Function

May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.

> Gene Ontology
 
Biological Process GO:0003016 respiratory system process
GO:0005976 polysaccharide metabolic process
GO:0005977 glycogen metabolic process
GO:0006073 cellular glucan metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006112 energy reserve metabolic process
GO:0007585 respiratory gaseous exchange
GO:0015980 energy derivation by oxidation of organic compounds
GO:0030323 respiratory tube development
GO:0030324 lung development
GO:0035264 multicellular organism growth
GO:0044042 glucan metabolic process
GO:0044262 cellular carbohydrate metabolic process
GO:0044264 cellular polysaccharide metabolic process
GO:0044723 single-organism carbohydrate metabolic process
GO:0048286 lung alveolus development
GO:0060425 lung morphogenesis
GO:0060541 respiratory system development
Molecular Function GO:0004674 protein serine/threonine kinase activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolSTK40
Nameserine/threonine kinase 40
Aliases MGC4796; SgK495; SHIK; SINK-homologous serine/threonine-protein kinase; Ser/Thr-like kinase; sugen kinase 49 ......
Chromosomal Location1p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between STK40 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolSTK40
Nameserine/threonine kinase 40
Aliases MGC4796; SgK495; SHIK; SINK-homologous serine/threonine-protein kinase; Ser/Thr-like kinase; sugen kinase 49 ......
Chromosomal Location1p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of STK40 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.61 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolSTK40
Nameserine/threonine kinase 40
Aliases MGC4796; SgK495; SHIK; SINK-homologous serine/threonine-protein kinase; Ser/Thr-like kinase; sugen kinase 49 ......
Chromosomal Location1p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of STK40 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1880.434
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.5430.796
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0690.964
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.350.276
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.6170.762
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0150.995
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.210.536
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0860.956
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.320.858
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.8160.541
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.4240.465
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.010.889
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of STK40 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSTK40
Nameserine/threonine kinase 40
Aliases MGC4796; SgK495; SHIK; SINK-homologous serine/threonine-protein kinase; Ser/Thr-like kinase; sugen kinase 49 ......
Chromosomal Location1p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of STK40. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSTK40
Nameserine/threonine kinase 40
Aliases MGC4796; SgK495; SHIK; SINK-homologous serine/threonine-protein kinase; Ser/Thr-like kinase; sugen kinase 49 ......
Chromosomal Location1p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of STK40. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by STK40.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSTK40
Nameserine/threonine kinase 40
Aliases MGC4796; SgK495; SHIK; SINK-homologous serine/threonine-protein kinase; Ser/Thr-like kinase; sugen kinase 49 ......
Chromosomal Location1p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of STK40. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSTK40
Nameserine/threonine kinase 40
Aliases MGC4796; SgK495; SHIK; SINK-homologous serine/threonine-protein kinase; Ser/Thr-like kinase; sugen kinase 49 ......
Chromosomal Location1p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of STK40 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSTK40
Nameserine/threonine kinase 40
Aliases MGC4796; SgK495; SHIK; SINK-homologous serine/threonine-protein kinase; Ser/Thr-like kinase; sugen kinase 49 ......
Chromosomal Location1p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between STK40 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSTK40
Nameserine/threonine kinase 40
Aliases MGC4796; SgK495; SHIK; SINK-homologous serine/threonine-protein kinase; Ser/Thr-like kinase; sugen kinase 49 ......
Chromosomal Location1p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting STK40 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.