Summary | |
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Symbol | STRA6 |
Name | stimulated by retinoic acid 6 |
Aliases | FLJ12541; retinol binding protein 4 receptor; stimulated by retinoic acid gene 6 homolog (mouse); stimulated ...... |
Chromosomal Location | 15q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Multi-pass membrane protein Note=In the retinal pigment epithelium localizes to the basolateral membrane. |
Domain | - |
Function |
Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1 (PubMed:9452451, PubMed:18316031, PubMed:22665496). Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A (PubMed:18316031, PubMed:22665496). Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin (PubMed:21368206, PubMed:22665496). Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid (PubMed:18316031). STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency (Probable). Does not transport retinoic acid (PubMed:18316031). |
Biological Process |
GO:0001523 retinoid metabolic process GO:0001654 eye development GO:0001655 urogenital system development GO:0001822 kidney development GO:0003170 heart valve development GO:0003177 pulmonary valve development GO:0003179 heart valve morphogenesis GO:0003184 pulmonary valve morphogenesis GO:0003205 cardiac chamber development GO:0003231 cardiac ventricle development GO:0003279 cardiac septum development GO:0003281 ventricular septum development GO:0006720 isoprenoid metabolic process GO:0006721 terpenoid metabolic process GO:0007423 sensory organ development GO:0007507 heart development GO:0007517 muscle organ development GO:0007548 sex differentiation GO:0007611 learning or memory GO:0007612 learning GO:0007631 feeding behavior GO:0007638 mechanosensory behavior GO:0009612 response to mechanical stimulus GO:0010171 body morphogenesis GO:0010996 response to auditory stimulus GO:0016101 diterpenoid metabolic process GO:0030323 respiratory tube development GO:0030324 lung development GO:0030325 adrenal gland development GO:0030540 female genitalia development GO:0031076 embryonic camera-type eye development GO:0031223 auditory behavior GO:0035239 tube morphogenesis GO:0035270 endocrine system development GO:0042297 vocal learning GO:0043010 camera-type eye development GO:0043583 ear development GO:0043584 nose development GO:0043585 nose morphogenesis GO:0044708 single-organism behavior GO:0046660 female sex differentiation GO:0048048 embryonic eye morphogenesis GO:0048286 lung alveolus development GO:0048514 blood vessel morphogenesis GO:0048520 positive regulation of behavior GO:0048546 digestive tract morphogenesis GO:0048562 embryonic organ morphogenesis GO:0048565 digestive tract development GO:0048566 embryonic digestive tract development GO:0048568 embryonic organ development GO:0048592 eye morphogenesis GO:0048593 camera-type eye morphogenesis GO:0048596 embryonic camera-type eye morphogenesis GO:0048608 reproductive structure development GO:0048732 gland development GO:0048745 smooth muscle tissue development GO:0048806 genitalia development GO:0048844 artery morphogenesis GO:0050795 regulation of behavior GO:0050890 cognition GO:0050905 neuromuscular process GO:0051180 vitamin transport GO:0055123 digestive system development GO:0060065 uterus development GO:0060323 head morphogenesis GO:0060324 face development GO:0060325 face morphogenesis GO:0060426 lung vasculature development GO:0060428 lung epithelium development GO:0060430 lung saccule development GO:0060537 muscle tissue development GO:0060538 skeletal muscle organ development GO:0060539 diaphragm development GO:0060541 respiratory system development GO:0060840 artery development GO:0060900 embryonic camera-type eye formation GO:0061029 eyelid development in camera-type eye GO:0061038 uterus morphogenesis GO:0061143 alveolar primary septum development GO:0061156 pulmonary artery morphogenesis GO:0061205 paramesonephric duct development GO:0061458 reproductive system development GO:0072001 renal system development GO:0090596 sensory organ morphogenesis GO:0097070 ductus arteriosus closure GO:0098596 imitative learning GO:0098597 observational learning GO:0098598 learned vocalization behavior or vocal learning GO:1905314 semi-lunar valve development |
Molecular Function |
GO:0051183 vitamin transporter activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-1643685: Disease R-HSA-2474795: Diseases associated with visual transduction R-HSA-5663202: Diseases of signal transduction R-HSA-2453864: Retinoid cycle disease events R-HSA-162582: Signal Transduction R-HSA-2453902: The canonical retinoid cycle in rods (twilight vision) R-HSA-2187338: Visual phototransduction |
Summary | |
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Symbol | STRA6 |
Name | stimulated by retinoic acid 6 |
Aliases | FLJ12541; retinol binding protein 4 receptor; stimulated by retinoic acid gene 6 homolog (mouse); stimulated ...... |
Chromosomal Location | 15q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between STRA6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | STRA6 |
Name | stimulated by retinoic acid 6 |
Aliases | FLJ12541; retinol binding protein 4 receptor; stimulated by retinoic acid gene 6 homolog (mouse); stimulated ...... |
Chromosomal Location | 15q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of STRA6 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | STRA6 |
Name | stimulated by retinoic acid 6 |
Aliases | FLJ12541; retinol binding protein 4 receptor; stimulated by retinoic acid gene 6 homolog (mouse); stimulated ...... |
Chromosomal Location | 15q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of STRA6 in various data sets.
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Points in the above scatter plot represent the mutation difference of STRA6 in various data sets.
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Summary | |
---|---|
Symbol | STRA6 |
Name | stimulated by retinoic acid 6 |
Aliases | FLJ12541; retinol binding protein 4 receptor; stimulated by retinoic acid gene 6 homolog (mouse); stimulated ...... |
Chromosomal Location | 15q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of STRA6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | STRA6 |
Name | stimulated by retinoic acid 6 |
Aliases | FLJ12541; retinol binding protein 4 receptor; stimulated by retinoic acid gene 6 homolog (mouse); stimulated ...... |
Chromosomal Location | 15q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of STRA6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by STRA6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | STRA6 |
Name | stimulated by retinoic acid 6 |
Aliases | FLJ12541; retinol binding protein 4 receptor; stimulated by retinoic acid gene 6 homolog (mouse); stimulated ...... |
Chromosomal Location | 15q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of STRA6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | STRA6 |
Name | stimulated by retinoic acid 6 |
Aliases | FLJ12541; retinol binding protein 4 receptor; stimulated by retinoic acid gene 6 homolog (mouse); stimulated ...... |
Chromosomal Location | 15q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of STRA6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | STRA6 |
Name | stimulated by retinoic acid 6 |
Aliases | FLJ12541; retinol binding protein 4 receptor; stimulated by retinoic acid gene 6 homolog (mouse); stimulated ...... |
Chromosomal Location | 15q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between STRA6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | STRA6 |
Name | stimulated by retinoic acid 6 |
Aliases | FLJ12541; retinol binding protein 4 receptor; stimulated by retinoic acid gene 6 homolog (mouse); stimulated ...... |
Chromosomal Location | 15q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting STRA6 collected from DrugBank database. |
There is no record. |