TISIDB

Summary
Symbol	STRADA
Name	STE20-related kinase adaptor alpha
Aliases	NY-BR-96; LYK5; Stlk; STRAD; STE20-like pseudokinase; PMSE; STRAD alpha; protein kinase LYK5; serologically ......
Chromosomal Location	17q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Nucleus Cytoplasm
Domain	PF00069 Protein kinase domain
Function	Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

> Gene Ontology [ TOP ]
Biological Process	GO:0006611 protein export from nucleus GO:0006913 nucleocytoplasmic transport GO:0007050 cell cycle arrest GO:0032147 activation of protein kinase activity GO:0033674 positive regulation of kinase activity GO:0045786 negative regulation of cell cycle GO:0045860 positive regulation of protein kinase activity GO:0051168 nuclear export GO:0051169 nuclear transport GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity
Molecular Function	GO:0008047 enzyme activator activity GO:0019207 kinase regulator activity GO:0019209 kinase activator activity GO:0019887 protein kinase regulator activity GO:0030295 protein kinase activator activity GO:0043539 protein serine/threonine kinase activator activity
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04150 mTOR signaling pathway hsa04152 AMPK signaling pathway
Reactome	R-HSA-380972: Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-74751: Insulin receptor signalling cascade R-HSA-109704: PI3K Cascade R-HSA-109703: PKB-mediated events R-HSA-162582: Signal Transduction R-HSA-74752: Signaling by Insulin receptor R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-165159: mTOR signalling

> KEGG and Reactome Pathway

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KEGG

hsa04150 mTOR signaling pathway
hsa04152 AMPK signaling pathway

Reactome

R-HSA-380972: Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-2428924: IGF1R signaling cascade
R-HSA-112399: IRS-mediated signalling
R-HSA-2428928: IRS-related events triggered by IGF1R
R-HSA-74751: Insulin receptor signalling cascade
R-HSA-109704: PI3K Cascade
R-HSA-109703: PKB-mediated events
R-HSA-162582: Signal Transduction
R-HSA-74752: Signaling by Insulin receptor
R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-165159: mTOR signalling

Summary
Symbol	STRADA
Name	STE20-related kinase adaptor alpha
Aliases	NY-BR-96; LYK5; Stlk; STRAD; STE20-like pseudokinase; PMSE; STRAD alpha; protein kinase LYK5; serologically ......
Chromosomal Location	17q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between STRADA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	STRADA
Name	STE20-related kinase adaptor alpha
Aliases	NY-BR-96; LYK5; Stlk; STRAD; STE20-like pseudokinase; PMSE; STRAD alpha; protein kinase LYK5; serologically ......
Chromosomal Location	17q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of STRADA in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	logFC: -2.70; FDR: 0.03680	Resistant to T cell-mediated killing
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	STRADA
Name	STE20-related kinase adaptor alpha
Aliases	NY-BR-96; LYK5; Stlk; STRAD; STE20-like pseudokinase; PMSE; STRAD alpha; protein kinase LYK5; serologically ......
Chromosomal Location	17q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of STRADA in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.117	0.53
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.028	0.988
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.181	0.894
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.451	0.178
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.301	0.879
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.645	0.807
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.022	0.941
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.036	0.98
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.119	0.94
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.103	0.943
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.264	0.9
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.042	0.454

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of STRADA in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	2.7	1	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	3.4	0.3	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	STRADA
Name	STE20-related kinase adaptor alpha
Aliases	NY-BR-96; LYK5; Stlk; STRAD; STE20-like pseudokinase; PMSE; STRAD alpha; protein kinase LYK5; serologically ......
Chromosomal Location	17q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of STRADA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	STRADA
Name	STE20-related kinase adaptor alpha
Aliases	NY-BR-96; LYK5; Stlk; STRAD; STE20-like pseudokinase; PMSE; STRAD alpha; protein kinase LYK5; serologically ......
Chromosomal Location	17q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of STRADA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by STRADA. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	STRADA
Name	STE20-related kinase adaptor alpha
Aliases	NY-BR-96; LYK5; Stlk; STRAD; STE20-like pseudokinase; PMSE; STRAD alpha; protein kinase LYK5; serologically ......
Chromosomal Location	17q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of STRADA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	STRADA
Name	STE20-related kinase adaptor alpha
Aliases	NY-BR-96; LYK5; Stlk; STRAD; STE20-like pseudokinase; PMSE; STRAD alpha; protein kinase LYK5; serologically ......
Chromosomal Location	17q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of STRADA expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	STRADA
Name	STE20-related kinase adaptor alpha
Aliases	NY-BR-96; LYK5; Stlk; STRAD; STE20-like pseudokinase; PMSE; STRAD alpha; protein kinase LYK5; serologically ......
Chromosomal Location	17q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between STRADA and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	STRADA
Name	STE20-related kinase adaptor alpha
Aliases	NY-BR-96; LYK5; Stlk; STRAD; STE20-like pseudokinase; PMSE; STRAD alpha; protein kinase LYK5; serologically ......
Chromosomal Location	17q23.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting STRADA collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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