Summary | |
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Symbol | STX17 |
Name | syntaxin 17 |
Aliases | FLJ20651; Syntaxin-17 |
Chromosomal Location | 9q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane Multi-pass membrane protein Smooth endoplasmic reticulum membrane Multi-pass membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane Multi-pass membrane protein Cytoplasmic vesicle, autophagosome membrane Multi-pass membrane protein Cytoplasmic vesicle, COPII-coated vesicle membrane Multi-pass membrane protein Cytoplasm, cytosol Note=Has a hairpin-like insertion into membranes. Localizes to the completed autophagosome membrane upon cell starvation (PubMed:23217709). May also localize to the mitochondria according to PubMed:23217709. |
Domain | - |
Function |
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604). May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355). |
Biological Process |
GO:0000045 autophagosome assembly GO:0006888 ER to Golgi vesicle-mediated transport GO:0006906 vesicle fusion GO:0006914 autophagy GO:0007030 Golgi organization GO:0007033 vacuole organization GO:0016050 vesicle organization GO:0016236 macroautophagy GO:0022406 membrane docking GO:0034497 protein localization to pre-autophagosomal structure GO:0044801 single-organism membrane fusion GO:0048193 Golgi vesicle transport GO:0048278 vesicle docking GO:0048284 organelle fusion GO:0061025 membrane fusion GO:0090174 organelle membrane fusion GO:0097111 endoplasmic reticulum-Golgi intermediate compartment organization GO:0097352 autophagosome maturation GO:0097576 vacuole fusion GO:1905037 autophagosome organization |
Molecular Function |
GO:0000149 SNARE binding GO:0005484 SNAP receptor activity GO:0019902 phosphatase binding GO:0019903 protein phosphatase binding |
Cellular Component |
GO:0000421 autophagosome membrane GO:0005776 autophagosome GO:0005790 smooth endoplasmic reticulum GO:0005793 endoplasmic reticulum-Golgi intermediate compartment GO:0012507 ER to Golgi transport vesicle membrane GO:0030133 transport vesicle GO:0030134 ER to Golgi transport vesicle GO:0030135 coated vesicle GO:0030658 transport vesicle membrane GO:0030659 cytoplasmic vesicle membrane GO:0030662 coated vesicle membrane GO:0030868 smooth endoplasmic reticulum membrane GO:0030897 HOPS complex GO:0031201 SNARE complex GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane GO:0044232 organelle membrane contact site GO:0044233 ER-mitochondrion membrane contact site GO:0097425 smooth endoplasmic reticulum part GO:0099023 tethring complex |
KEGG |
hsa04130 SNARE interactions in vesicular transport hsa04140 Regulation of autophagy |
Reactome |
R-HSA-446203: Asparagine N-linked glycosylation R-HSA-204005: COPII (Coat Protein 2) Mediated Vesicle Transport R-HSA-199977: ER to Golgi Anterograde Transport R-HSA-199991: Membrane Trafficking R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-948021: Transport to the Golgi and subsequent modification R-HSA-5653656: Vesicle-mediated transport |
Summary | |
---|---|
Symbol | STX17 |
Name | syntaxin 17 |
Aliases | FLJ20651; Syntaxin-17 |
Chromosomal Location | 9q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between STX17 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | STX17 |
Name | syntaxin 17 |
Aliases | FLJ20651; Syntaxin-17 |
Chromosomal Location | 9q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of STX17 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | STX17 |
Name | syntaxin 17 |
Aliases | FLJ20651; Syntaxin-17 |
Chromosomal Location | 9q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of STX17 in various data sets.
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Points in the above scatter plot represent the mutation difference of STX17 in various data sets.
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Summary | |
---|---|
Symbol | STX17 |
Name | syntaxin 17 |
Aliases | FLJ20651; Syntaxin-17 |
Chromosomal Location | 9q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of STX17. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | STX17 |
Name | syntaxin 17 |
Aliases | FLJ20651; Syntaxin-17 |
Chromosomal Location | 9q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of STX17. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by STX17. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | STX17 |
Name | syntaxin 17 |
Aliases | FLJ20651; Syntaxin-17 |
Chromosomal Location | 9q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of STX17. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | STX17 |
Name | syntaxin 17 |
Aliases | FLJ20651; Syntaxin-17 |
Chromosomal Location | 9q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of STX17 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | STX17 |
Name | syntaxin 17 |
Aliases | FLJ20651; Syntaxin-17 |
Chromosomal Location | 9q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between STX17 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |