Summary | |
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Symbol | STX19 |
Name | syntaxin 19 |
Aliases | MGC21382; Syntaxin-19 |
Chromosomal Location | 3q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Peripheral membrane protein Cytoplasm |
Domain |
PF00804 Syntaxin |
Function |
Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR). |
Biological Process |
GO:0001505 regulation of neurotransmitter levels GO:0006836 neurotransmitter transport GO:0006887 exocytosis GO:0006906 vesicle fusion GO:0007269 neurotransmitter secretion GO:0016050 vesicle organization GO:0016079 synaptic vesicle exocytosis GO:0017156 calcium ion regulated exocytosis GO:0022406 membrane docking GO:0023061 signal release GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane GO:0044801 single-organism membrane fusion GO:0045026 plasma membrane fusion GO:0045055 regulated exocytosis GO:0048278 vesicle docking GO:0048284 organelle fusion GO:0048489 synaptic vesicle transport GO:0051640 organelle localization GO:0051648 vesicle localization GO:0051650 establishment of vesicle localization GO:0051656 establishment of organelle localization GO:0061025 membrane fusion GO:0090174 organelle membrane fusion GO:0097479 synaptic vesicle localization GO:0097480 establishment of synaptic vesicle localization GO:0099003 vesicle-mediated transport in synapse GO:0099500 vesicle fusion to plasma membrane GO:0099504 synaptic vesicle cycle GO:0099531 presynaptic process involved in chemical synaptic transmission GO:0099643 signal release from synapse |
Molecular Function |
GO:0000149 SNARE binding GO:0005484 SNAP receptor activity |
Cellular Component |
GO:0008021 synaptic vesicle GO:0030133 transport vesicle GO:0031201 SNARE complex GO:0070382 exocytic vesicle GO:0098793 presynapse GO:0099503 secretory vesicle |
KEGG |
hsa04130 SNARE interactions in vesicular transport |
Reactome | - |
Summary | |
---|---|
Symbol | STX19 |
Name | syntaxin 19 |
Aliases | MGC21382; Syntaxin-19 |
Chromosomal Location | 3q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between STX19 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | STX19 |
Name | syntaxin 19 |
Aliases | MGC21382; Syntaxin-19 |
Chromosomal Location | 3q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of STX19 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | STX19 |
Name | syntaxin 19 |
Aliases | MGC21382; Syntaxin-19 |
Chromosomal Location | 3q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of STX19 in various data sets.
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Points in the above scatter plot represent the mutation difference of STX19 in various data sets.
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Summary | |
---|---|
Symbol | STX19 |
Name | syntaxin 19 |
Aliases | MGC21382; Syntaxin-19 |
Chromosomal Location | 3q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of STX19. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | STX19 |
Name | syntaxin 19 |
Aliases | MGC21382; Syntaxin-19 |
Chromosomal Location | 3q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of STX19. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by STX19. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | STX19 |
Name | syntaxin 19 |
Aliases | MGC21382; Syntaxin-19 |
Chromosomal Location | 3q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of STX19. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | STX19 |
Name | syntaxin 19 |
Aliases | MGC21382; Syntaxin-19 |
Chromosomal Location | 3q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of STX19 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | STX19 |
Name | syntaxin 19 |
Aliases | MGC21382; Syntaxin-19 |
Chromosomal Location | 3q11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between STX19 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |