Browse SULT1A3

Summary
SymbolSULT1A3
Namesulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
Aliases STM; HAST; ST1A5; dopamine-specific sulfotransferase; monoamine-sulfating phenosulfotransferase; phenol sulf ......
Chromosomal Location16p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm.
Domain PF00685 Sulfotransferase domain
Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.

> Gene Ontology
 
Biological Process GO:0006584 catecholamine metabolic process
GO:0006790 sulfur compound metabolic process
GO:0006805 xenobiotic metabolic process
GO:0006986 response to unfolded protein
GO:0008202 steroid metabolic process
GO:0009116 nucleoside metabolic process
GO:0009119 ribonucleoside metabolic process
GO:0009150 purine ribonucleotide metabolic process
GO:0009410 response to xenobiotic stimulus
GO:0009712 catechol-containing compound metabolic process
GO:0009812 flavonoid metabolic process
GO:0018958 phenol-containing compound metabolic process
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0033865 nucleoside bisphosphate metabolic process
GO:0033875 ribonucleoside bisphosphate metabolic process
GO:0034032 purine nucleoside bisphosphate metabolic process
GO:0034035 purine ribonucleoside bisphosphate metabolic process
GO:0034620 cellular response to unfolded protein
GO:0034976 response to endoplasmic reticulum stress
GO:0035966 response to topologically incorrect protein
GO:0035967 cellular response to topologically incorrect protein
GO:0036498 IRE1-mediated unfolded protein response
GO:0042278 purine nucleoside metabolic process
GO:0046128 purine ribonucleoside metabolic process
GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0051923 sulfation
GO:0071466 cellular response to xenobiotic stimulus
GO:1901615 organic hydroxy compound metabolic process
GO:1901657 glycosyl compound metabolic process
Molecular Function GO:0004062 aryl sulfotransferase activity
GO:0008146 sulfotransferase activity
GO:0016782 transferase activity, transferring sulfur-containing groups
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-211859: Biological oxidations
R-HSA-156584: Cytosolic sulfonation of small molecules
R-HSA-381070: IRE1alpha activates chaperones
R-HSA-1430728: Metabolism
R-HSA-392499: Metabolism of proteins
R-HSA-156580: Phase II conjugation
R-HSA-381119: Unfolded Protein Response (UPR)
R-HSA-381038: XBP1(S) activates chaperone genes
Summary
SymbolSULT1A3
Namesulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
Aliases STM; HAST; ST1A5; dopamine-specific sulfotransferase; monoamine-sulfating phenosulfotransferase; phenol sulf ......
Chromosomal Location16p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SULT1A3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSULT1A3
Namesulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
Aliases STM; HAST; ST1A5; dopamine-specific sulfotransferase; monoamine-sulfating phenosulfotransferase; phenol sulf ......
Chromosomal Location16p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SULT1A3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.51 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolSULT1A3
Namesulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
Aliases STM; HAST; ST1A5; dopamine-specific sulfotransferase; monoamine-sulfating phenosulfotransferase; phenol sulf ......
Chromosomal Location16p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SULT1A3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1570.588
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2640.918
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0260.994
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.3420.24
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.5130.305
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1860.724
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.2290.865
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.4130.819
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 6823001
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SULT1A3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSULT1A3
Namesulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
Aliases STM; HAST; ST1A5; dopamine-specific sulfotransferase; monoamine-sulfating phenosulfotransferase; phenol sulf ......
Chromosomal Location16p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SULT1A3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSULT1A3
Namesulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
Aliases STM; HAST; ST1A5; dopamine-specific sulfotransferase; monoamine-sulfating phenosulfotransferase; phenol sulf ......
Chromosomal Location16p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SULT1A3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SULT1A3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSULT1A3
Namesulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
Aliases STM; HAST; ST1A5; dopamine-specific sulfotransferase; monoamine-sulfating phenosulfotransferase; phenol sulf ......
Chromosomal Location16p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SULT1A3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSULT1A3
Namesulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
Aliases STM; HAST; ST1A5; dopamine-specific sulfotransferase; monoamine-sulfating phenosulfotransferase; phenol sulf ......
Chromosomal Location16p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SULT1A3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSULT1A3
Namesulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
Aliases STM; HAST; ST1A5; dopamine-specific sulfotransferase; monoamine-sulfating phenosulfotransferase; phenol sulf ......
Chromosomal Location16p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SULT1A3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSULT1A3
Namesulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
Aliases STM; HAST; ST1A5; dopamine-specific sulfotransferase; monoamine-sulfating phenosulfotransferase; phenol sulf ......
Chromosomal Location16p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SULT1A3 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.