Summary | |
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Symbol | SULT6B1 |
Name | sulfotransferase family, cytosolic, 6B, member 1 |
Aliases | ST6B1; sulfotransferase SULT6B1; thyroxine sulfotransferase; Sulfotransferase 6B1 |
Chromosomal Location | 2p22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm |
Domain |
PF00685 Sulfotransferase domain |
Function |
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of thyroxine. Involved in the metabolism of thyroxine (By similarity). |
Biological Process | - |
Molecular Function |
GO:0008146 sulfotransferase activity GO:0016782 transferase activity, transferring sulfur-containing groups |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | SULT6B1 |
Name | sulfotransferase family, cytosolic, 6B, member 1 |
Aliases | ST6B1; sulfotransferase SULT6B1; thyroxine sulfotransferase; Sulfotransferase 6B1 |
Chromosomal Location | 2p22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SULT6B1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SULT6B1 |
Name | sulfotransferase family, cytosolic, 6B, member 1 |
Aliases | ST6B1; sulfotransferase SULT6B1; thyroxine sulfotransferase; Sulfotransferase 6B1 |
Chromosomal Location | 2p22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SULT6B1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | SULT6B1 |
Name | sulfotransferase family, cytosolic, 6B, member 1 |
Aliases | ST6B1; sulfotransferase SULT6B1; thyroxine sulfotransferase; Sulfotransferase 6B1 |
Chromosomal Location | 2p22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SULT6B1 in various data sets.
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Points in the above scatter plot represent the mutation difference of SULT6B1 in various data sets.
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Summary | |
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Symbol | SULT6B1 |
Name | sulfotransferase family, cytosolic, 6B, member 1 |
Aliases | ST6B1; sulfotransferase SULT6B1; thyroxine sulfotransferase; Sulfotransferase 6B1 |
Chromosomal Location | 2p22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SULT6B1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SULT6B1 |
Name | sulfotransferase family, cytosolic, 6B, member 1 |
Aliases | ST6B1; sulfotransferase SULT6B1; thyroxine sulfotransferase; Sulfotransferase 6B1 |
Chromosomal Location | 2p22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SULT6B1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SULT6B1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SULT6B1 |
Name | sulfotransferase family, cytosolic, 6B, member 1 |
Aliases | ST6B1; sulfotransferase SULT6B1; thyroxine sulfotransferase; Sulfotransferase 6B1 |
Chromosomal Location | 2p22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SULT6B1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SULT6B1 |
Name | sulfotransferase family, cytosolic, 6B, member 1 |
Aliases | ST6B1; sulfotransferase SULT6B1; thyroxine sulfotransferase; Sulfotransferase 6B1 |
Chromosomal Location | 2p22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SULT6B1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SULT6B1 |
Name | sulfotransferase family, cytosolic, 6B, member 1 |
Aliases | ST6B1; sulfotransferase SULT6B1; thyroxine sulfotransferase; Sulfotransferase 6B1 |
Chromosomal Location | 2p22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SULT6B1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SULT6B1 |
Name | sulfotransferase family, cytosolic, 6B, member 1 |
Aliases | ST6B1; sulfotransferase SULT6B1; thyroxine sulfotransferase; Sulfotransferase 6B1 |
Chromosomal Location | 2p22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SULT6B1 collected from DrugBank database. |
There is no record. |