Summary | |
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Symbol | SUPT6H |
Name | SPT6 homolog, histone chaperone |
Aliases | KIAA0162; SPT6H; suppressor of Ty (S.cerevisiae) 6 homolog; suppressor of Ty 6 homolog (S. cerevisiae); SPT6 ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF14878 Death-like domain of SPT6 PF14635 Helix-hairpin-helix motif PF14641 Helix-turn-helix DNA-binding domain of SPT6 PF00575 S1 RNA binding domain PF14633 SH2 domain PF14632 Acidic N-terminal SPT6 PF14639 Holliday-junction resolvase-like of SPT6 |
Function |
Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A. |
Biological Process |
GO:0000018 regulation of DNA recombination GO:0002200 somatic diversification of immune receptors GO:0002204 somatic recombination of immunoglobulin genes involved in immune response GO:0002208 somatic diversification of immunoglobulins involved in immune response GO:0002250 adaptive immune response GO:0002263 cell activation involved in immune response GO:0002285 lymphocyte activation involved in immune response GO:0002312 B cell activation involved in immune response GO:0002366 leukocyte activation involved in immune response GO:0002377 immunoglobulin production GO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002440 production of molecular mediator of immune response GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus GO:0002637 regulation of immunoglobulin production GO:0002694 regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002700 regulation of production of molecular mediator of immune response GO:0002703 regulation of leukocyte mediated immunity GO:0002706 regulation of lymphocyte mediated immunity GO:0002712 regulation of B cell mediated immunity GO:0002819 regulation of adaptive immune response GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002889 regulation of immunoglobulin mediated immune response GO:0006310 DNA recombination GO:0006338 chromatin remodeling GO:0006354 DNA-templated transcription, elongation GO:0006368 transcription elongation from RNA polymerase II promoter GO:0006397 mRNA processing GO:0006403 RNA localization GO:0006405 RNA export from nucleus GO:0006406 mRNA export from nucleus GO:0006479 protein methylation GO:0006913 nucleocytoplasmic transport GO:0008213 protein alkylation GO:0008380 RNA splicing GO:0010793 regulation of mRNA export from nucleus GO:0015931 nucleobase-containing compound transport GO:0016064 immunoglobulin mediated immune response GO:0016444 somatic cell DNA recombination GO:0016445 somatic diversification of immunoglobulins GO:0016447 somatic recombination of immunoglobulin gene segments GO:0016570 histone modification GO:0016571 histone methylation GO:0018022 peptidyl-lysine methylation GO:0018205 peptidyl-lysine modification GO:0019724 B cell mediated immunity GO:0031056 regulation of histone modification GO:0031057 negative regulation of histone modification GO:0031060 regulation of histone methylation GO:0031061 negative regulation of histone methylation GO:0032239 regulation of nucleobase-containing compound transport GO:0032259 methylation GO:0032386 regulation of intracellular transport GO:0032784 regulation of DNA-templated transcription, elongation GO:0032786 positive regulation of DNA-templated transcription, elongation GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter GO:0034243 regulation of transcription elongation from RNA polymerase II promoter GO:0034968 histone lysine methylation GO:0042113 B cell activation GO:0042692 muscle cell differentiation GO:0043414 macromolecule methylation GO:0045190 isotype switching GO:0045191 regulation of isotype switching GO:0046822 regulation of nucleocytoplasmic transport GO:0046831 regulation of RNA export from nucleus GO:0050657 nucleic acid transport GO:0050658 RNA transport GO:0050684 regulation of mRNA processing GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0051028 mRNA transport GO:0051052 regulation of DNA metabolic process GO:0051147 regulation of muscle cell differentiation GO:0051168 nuclear export GO:0051169 nuclear transport GO:0051236 establishment of RNA localization GO:0051249 regulation of lymphocyte activation GO:0061085 regulation of histone H3-K27 methylation GO:0061086 negative regulation of histone H3-K27 methylation GO:0070734 histone H3-K27 methylation GO:0071166 ribonucleoprotein complex localization GO:0071426 ribonucleoprotein complex export from nucleus GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus GO:1902275 regulation of chromatin organization GO:1903311 regulation of mRNA metabolic process GO:1905268 negative regulation of chromatin organization GO:2000197 regulation of ribonucleoprotein complex localization |
Molecular Function |
GO:0042393 histone binding |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-112387: Elongation arrest and recovery R-HSA-112382: Formation of RNA Pol II elongation complex R-HSA-74160: Gene Expression R-HSA-674695: RNA Polymerase II Pre-transcription Events R-HSA-73857: RNA Polymerase II Transcription R-HSA-75955: RNA Polymerase II Transcription Elongation |
Summary | |
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Symbol | SUPT6H |
Name | SPT6 homolog, histone chaperone |
Aliases | KIAA0162; SPT6H; suppressor of Ty (S.cerevisiae) 6 homolog; suppressor of Ty 6 homolog (S. cerevisiae); SPT6 ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SUPT6H and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SUPT6H |
Name | SPT6 homolog, histone chaperone |
Aliases | KIAA0162; SPT6H; suppressor of Ty (S.cerevisiae) 6 homolog; suppressor of Ty 6 homolog (S. cerevisiae); SPT6 ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SUPT6H in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SUPT6H |
Name | SPT6 homolog, histone chaperone |
Aliases | KIAA0162; SPT6H; suppressor of Ty (S.cerevisiae) 6 homolog; suppressor of Ty 6 homolog (S. cerevisiae); SPT6 ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SUPT6H in various data sets.
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Points in the above scatter plot represent the mutation difference of SUPT6H in various data sets.
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Summary | |
---|---|
Symbol | SUPT6H |
Name | SPT6 homolog, histone chaperone |
Aliases | KIAA0162; SPT6H; suppressor of Ty (S.cerevisiae) 6 homolog; suppressor of Ty 6 homolog (S. cerevisiae); SPT6 ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SUPT6H. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SUPT6H |
Name | SPT6 homolog, histone chaperone |
Aliases | KIAA0162; SPT6H; suppressor of Ty (S.cerevisiae) 6 homolog; suppressor of Ty 6 homolog (S. cerevisiae); SPT6 ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SUPT6H. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SUPT6H. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SUPT6H |
Name | SPT6 homolog, histone chaperone |
Aliases | KIAA0162; SPT6H; suppressor of Ty (S.cerevisiae) 6 homolog; suppressor of Ty 6 homolog (S. cerevisiae); SPT6 ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SUPT6H. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SUPT6H |
Name | SPT6 homolog, histone chaperone |
Aliases | KIAA0162; SPT6H; suppressor of Ty (S.cerevisiae) 6 homolog; suppressor of Ty 6 homolog (S. cerevisiae); SPT6 ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SUPT6H expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SUPT6H |
Name | SPT6 homolog, histone chaperone |
Aliases | KIAA0162; SPT6H; suppressor of Ty (S.cerevisiae) 6 homolog; suppressor of Ty 6 homolog (S. cerevisiae); SPT6 ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SUPT6H and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SUPT6H |
Name | SPT6 homolog, histone chaperone |
Aliases | KIAA0162; SPT6H; suppressor of Ty (S.cerevisiae) 6 homolog; suppressor of Ty 6 homolog (S. cerevisiae); SPT6 ...... |
Chromosomal Location | 17q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SUPT6H collected from DrugBank database. |
There is no record. |