Summary | |
---|---|
Symbol | SUSD2 |
Name | sushi domain containing 2 |
Aliases | BK65A6.2; FLJ22778; Sushi domain (SCR repeat) containing; Sushi domain-containing protein 2 |
Chromosomal Location | 22q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein Note=SUSD2 and LGALS1 co-localized in very specific, punctate regions along the cell membrane of breast cancer cells. |
Domain |
PF03782 AMOP domain PF01033 Somatomedin B domain PF00084 Sushi repeat (SCR repeat) PF00094 von Willebrand factor type D domain |
Function |
May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May play a role in breast tumorigenesis (PubMed:23131994). |
Biological Process |
GO:0006898 receptor-mediated endocytosis GO:0010948 negative regulation of cell cycle process GO:0044770 cell cycle phase transition GO:0044843 cell cycle G1/S phase transition GO:0045786 negative regulation of cell cycle GO:0051302 regulation of cell division GO:0051782 negative regulation of cell division GO:1901987 regulation of cell cycle phase transition GO:1901988 negative regulation of cell cycle phase transition GO:1902806 regulation of cell cycle G1/S phase transition GO:1902807 negative regulation of cell cycle G1/S phase transition |
Molecular Function |
GO:0001871 pattern binding GO:0005044 scavenger receptor activity GO:0030246 carbohydrate binding GO:0030247 polysaccharide binding GO:0038024 cargo receptor activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | SUSD2 |
Name | sushi domain containing 2 |
Aliases | BK65A6.2; FLJ22778; Sushi domain (SCR repeat) containing; Sushi domain-containing protein 2 |
Chromosomal Location | 22q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SUSD2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between SUSD2 and anti-tumor immunity in human cancer.
|
Summary | |
---|---|
Symbol | SUSD2 |
Name | sushi domain containing 2 |
Aliases | BK65A6.2; FLJ22778; Sushi domain (SCR repeat) containing; Sushi domain-containing protein 2 |
Chromosomal Location | 22q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of SUSD2 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | SUSD2 |
Name | sushi domain containing 2 |
Aliases | BK65A6.2; FLJ22778; Sushi domain (SCR repeat) containing; Sushi domain-containing protein 2 |
Chromosomal Location | 22q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SUSD2 in various data sets.
|
Points in the above scatter plot represent the mutation difference of SUSD2 in various data sets.
|
Summary | |
---|---|
Symbol | SUSD2 |
Name | sushi domain containing 2 |
Aliases | BK65A6.2; FLJ22778; Sushi domain (SCR repeat) containing; Sushi domain-containing protein 2 |
Chromosomal Location | 22q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SUSD2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SUSD2 |
Name | sushi domain containing 2 |
Aliases | BK65A6.2; FLJ22778; Sushi domain (SCR repeat) containing; Sushi domain-containing protein 2 |
Chromosomal Location | 22q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SUSD2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SUSD2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SUSD2 |
Name | sushi domain containing 2 |
Aliases | BK65A6.2; FLJ22778; Sushi domain (SCR repeat) containing; Sushi domain-containing protein 2 |
Chromosomal Location | 22q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SUSD2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SUSD2 |
Name | sushi domain containing 2 |
Aliases | BK65A6.2; FLJ22778; Sushi domain (SCR repeat) containing; Sushi domain-containing protein 2 |
Chromosomal Location | 22q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SUSD2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SUSD2 |
Name | sushi domain containing 2 |
Aliases | BK65A6.2; FLJ22778; Sushi domain (SCR repeat) containing; Sushi domain-containing protein 2 |
Chromosomal Location | 22q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SUSD2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SUSD2 |
Name | sushi domain containing 2 |
Aliases | BK65A6.2; FLJ22778; Sushi domain (SCR repeat) containing; Sushi domain-containing protein 2 |
Chromosomal Location | 22q11-q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SUSD2 collected from DrugBank database. |
There is no record. |