Summary | |
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Symbol | SUZ12 |
Name | SUZ12 polycomb repressive complex 2 subunit |
Aliases | JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF09733 VEFS-Box of polycomb protein |
Function |
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. |
Biological Process |
GO:0006479 protein methylation GO:0008213 protein alkylation GO:0016570 histone modification GO:0016571 histone methylation GO:0016574 histone ubiquitination GO:0032259 methylation GO:0040029 regulation of gene expression, epigenetic GO:0043414 macromolecule methylation GO:0045814 negative regulation of gene expression, epigenetic |
Molecular Function |
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding GO:0003682 chromatin binding GO:0008168 methyltransferase activity GO:0008276 protein methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups GO:0031490 chromatin DNA binding GO:0035064 methylated histone binding GO:0042054 histone methyltransferase activity GO:0042393 histone binding GO:0043566 structure-specific DNA binding |
Cellular Component |
GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0000792 heterochromatin GO:0000803 sex chromosome GO:0001739 sex chromatin GO:0005720 nuclear heterochromatin GO:0031519 PcG protein complex GO:0032993 protein-DNA complex GO:0034708 methyltransferase complex GO:0035097 histone methyltransferase complex GO:0035098 ESC/E(Z) complex GO:0044454 nuclear chromosome part |
KEGG | - |
Reactome |
R-HSA-5619507: Activation of HOX genes during differentiation R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-1266738: Developmental Biology R-HSA-212165: Epigenetic regulation of gene expression R-HSA-74160: Gene Expression R-HSA-2559580: Oxidative Stress Induced Senescence R-HSA-3214841: PKMTs methylate histone lysines R-HSA-212300: PRC2 methylates histones and DNA |
Summary | |
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Symbol | SUZ12 |
Name | SUZ12 polycomb repressive complex 2 subunit |
Aliases | JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SUZ12 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between SUZ12 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | SUZ12 |
Name | SUZ12 polycomb repressive complex 2 subunit |
Aliases | JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SUZ12 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SUZ12 |
Name | SUZ12 polycomb repressive complex 2 subunit |
Aliases | JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SUZ12 in various data sets.
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Points in the above scatter plot represent the mutation difference of SUZ12 in various data sets.
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Summary | |
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Symbol | SUZ12 |
Name | SUZ12 polycomb repressive complex 2 subunit |
Aliases | JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SUZ12. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SUZ12 |
Name | SUZ12 polycomb repressive complex 2 subunit |
Aliases | JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SUZ12. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SUZ12. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SUZ12 |
Name | SUZ12 polycomb repressive complex 2 subunit |
Aliases | JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SUZ12. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SUZ12 |
Name | SUZ12 polycomb repressive complex 2 subunit |
Aliases | JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SUZ12 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SUZ12 |
Name | SUZ12 polycomb repressive complex 2 subunit |
Aliases | JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SUZ12 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SUZ12 |
Name | SUZ12 polycomb repressive complex 2 subunit |
Aliases | JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SUZ12 collected from DrugBank database. |
There is no record. |