Browse SUZ12

Summary
SymbolSUZ12
NameSUZ12 polycomb repressive complex 2 subunit
Aliases JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF09733 VEFS-Box of polycomb protein
Function

Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.

> Gene Ontology
 
Biological Process GO:0006479 protein methylation
GO:0008213 protein alkylation
GO:0016570 histone modification
GO:0016571 histone methylation
GO:0016574 histone ubiquitination
GO:0032259 methylation
GO:0040029 regulation of gene expression, epigenetic
GO:0043414 macromolecule methylation
GO:0045814 negative regulation of gene expression, epigenetic
Molecular Function GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0001047 core promoter binding
GO:0003682 chromatin binding
GO:0008168 methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0016741 transferase activity, transferring one-carbon groups
GO:0031490 chromatin DNA binding
GO:0035064 methylated histone binding
GO:0042054 histone methyltransferase activity
GO:0042393 histone binding
GO:0043566 structure-specific DNA binding
Cellular Component GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0000792 heterochromatin
GO:0000803 sex chromosome
GO:0001739 sex chromatin
GO:0005720 nuclear heterochromatin
GO:0031519 PcG protein complex
GO:0032993 protein-DNA complex
GO:0034708 methyltransferase complex
GO:0035097 histone methyltransferase complex
GO:0035098 ESC/E(Z) complex
GO:0044454 nuclear chromosome part
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-5619507: Activation of HOX genes during differentiation
R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-2559583: Cellular Senescence
R-HSA-2262752: Cellular responses to stress
R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-1266738: Developmental Biology
R-HSA-212165: Epigenetic regulation of gene expression
R-HSA-74160: Gene Expression
R-HSA-2559580: Oxidative Stress Induced Senescence
R-HSA-3214841: PKMTs methylate histone lysines
R-HSA-212300: PRC2 methylates histones and DNA
Summary
SymbolSUZ12
NameSUZ12 polycomb repressive complex 2 subunit
Aliases JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SUZ12 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between SUZ12 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
26567139Colon CarcinomaInhibit immunity (infiltration)We found that PRC2 components and demethylase JMJD3-mediated histone H3 lysine 27 trimethylation (H3K27me3) repress the expression and subsequent production of Th1-type chemokines CXCL9 and CXCL10, mediators of effector T-cell trafficking. Moreover, the expression levels of PRC2 components, including EZH2, SUZ12, and EED, were inversely associated with those of CD4, CD8, and Th1-type chemokines in human colon cancer tissue, and this expression pattern was significantly associated with patient survival.
Summary
SymbolSUZ12
NameSUZ12 polycomb repressive complex 2 subunit
Aliases JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SUZ12 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSUZ12
NameSUZ12 polycomb repressive complex 2 subunit
Aliases JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SUZ12 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1290.532
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1960.91
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.080.95
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2570.403
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1810.927
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3550.89
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1680.657
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1520.929
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1790.925
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0660.952
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.7610.624
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1780.0104
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SUZ12 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSUZ12
NameSUZ12 polycomb repressive complex 2 subunit
Aliases JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SUZ12. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSUZ12
NameSUZ12 polycomb repressive complex 2 subunit
Aliases JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SUZ12. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SUZ12.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSUZ12
NameSUZ12 polycomb repressive complex 2 subunit
Aliases JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SUZ12. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSUZ12
NameSUZ12 polycomb repressive complex 2 subunit
Aliases JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SUZ12 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSUZ12
NameSUZ12 polycomb repressive complex 2 subunit
Aliases JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SUZ12 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSUZ12
NameSUZ12 polycomb repressive complex 2 subunit
Aliases JJAZ1; KIAA0160; CHET9; suppressor of zeste 12 homolog (Drosophila); chET 9 protein; chromatin precipitated ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SUZ12 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.