Summary | |
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Symbol | SWAP70 |
Name | SWAP switching B-cell complex 70kDa subunit |
Aliases | KIAA0640; SWAP-70; HSPC321; Switch-associated protein 70 |
Chromosomal Location | 11p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Cell membrane. Nucleus Cell projection, lamellipodium Cytoplasm, cytoskeleton Note=In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus (PubMed:10681448). In activated, class-switching B-cells it is associated with membrane IgG but not IgM (PubMed:10681448). Localized to loose actin filament arrays located behind actively extending lamellipodia (PubMed:12925760). |
Domain |
PF00169 PH domain |
Function |
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity). |
Biological Process |
GO:0002200 somatic diversification of immune receptors GO:0002204 somatic recombination of immunoglobulin genes involved in immune response GO:0002208 somatic diversification of immunoglobulins involved in immune response GO:0002250 adaptive immune response GO:0002263 cell activation involved in immune response GO:0002285 lymphocyte activation involved in immune response GO:0002312 B cell activation involved in immune response GO:0002366 leukocyte activation involved in immune response GO:0002377 immunoglobulin production GO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002440 production of molecular mediator of immune response GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002551 mast cell chemotaxis GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002688 regulation of leukocyte chemotaxis GO:0002690 positive regulation of leukocyte chemotaxis GO:0006310 DNA recombination GO:0006470 protein dephosphorylation GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0007015 actin filament organization GO:0007162 negative regulation of cell adhesion GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0008064 regulation of actin polymerization or depolymerization GO:0008154 actin polymerization or depolymerization GO:0010639 negative regulation of organelle organization GO:0016064 immunoglobulin mediated immune response GO:0016311 dephosphorylation GO:0016444 somatic cell DNA recombination GO:0016445 somatic diversification of immunoglobulins GO:0016447 somatic recombination of immunoglobulin gene segments GO:0019724 B cell mediated immunity GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0030042 actin filament depolymerization GO:0030335 positive regulation of cell migration GO:0030595 leukocyte chemotaxis GO:0030832 regulation of actin filament length GO:0030834 regulation of actin filament depolymerization GO:0030835 negative regulation of actin filament depolymerization GO:0032103 positive regulation of response to external stimulus GO:0032231 regulation of actin filament bundle assembly GO:0032233 positive regulation of actin filament bundle assembly GO:0032535 regulation of cellular component size GO:0032956 regulation of actin cytoskeleton organization GO:0032970 regulation of actin filament-based process GO:0032984 macromolecular complex disassembly GO:0033627 cell adhesion mediated by integrin GO:0033628 regulation of cell adhesion mediated by integrin GO:0033629 negative regulation of cell adhesion mediated by integrin GO:0033631 cell-cell adhesion mediated by integrin GO:0033632 regulation of cell-cell adhesion mediated by integrin GO:0033633 negative regulation of cell-cell adhesion mediated by integrin GO:0035303 regulation of dephosphorylation GO:0035304 regulation of protein dephosphorylation GO:0035305 negative regulation of dephosphorylation GO:0035308 negative regulation of protein dephosphorylation GO:0040017 positive regulation of locomotion GO:0042113 B cell activation GO:0043241 protein complex disassembly GO:0043242 negative regulation of protein complex disassembly GO:0043244 regulation of protein complex disassembly GO:0043624 cellular protein complex disassembly GO:0044089 positive regulation of cellular component biogenesis GO:0045190 isotype switching GO:0050900 leukocyte migration GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0051017 actin filament bundle assembly GO:0051261 protein depolymerization GO:0051272 positive regulation of cellular component movement GO:0051480 regulation of cytosolic calcium ion concentration GO:0051493 regulation of cytoskeleton organization GO:0051494 negative regulation of cytoskeleton organization GO:0051495 positive regulation of cytoskeleton organization GO:0055074 calcium ion homeostasis GO:0060326 cell chemotaxis GO:0060753 regulation of mast cell chemotaxis GO:0060754 positive regulation of mast cell chemotaxis GO:0061572 actin filament bundle organization GO:0070262 peptidyl-serine dephosphorylation GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0090066 regulation of anatomical structure size GO:0097529 myeloid leukocyte migration GO:0097531 mast cell migration GO:1901879 regulation of protein depolymerization GO:1901880 negative regulation of protein depolymerization GO:1902308 regulation of peptidyl-serine dephosphorylation GO:1902309 negative regulation of peptidyl-serine dephosphorylation GO:2000147 positive regulation of cell motility |
Molecular Function |
GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0005913 cell-cell adherens junction GO:0030027 lamellipodium GO:0031252 cell leading edge |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | SWAP70 |
Name | SWAP switching B-cell complex 70kDa subunit |
Aliases | KIAA0640; SWAP-70; HSPC321; Switch-associated protein 70 |
Chromosomal Location | 11p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SWAP70 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SWAP70 |
Name | SWAP switching B-cell complex 70kDa subunit |
Aliases | KIAA0640; SWAP-70; HSPC321; Switch-associated protein 70 |
Chromosomal Location | 11p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SWAP70 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | SWAP70 |
Name | SWAP switching B-cell complex 70kDa subunit |
Aliases | KIAA0640; SWAP-70; HSPC321; Switch-associated protein 70 |
Chromosomal Location | 11p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SWAP70 in various data sets.
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Points in the above scatter plot represent the mutation difference of SWAP70 in various data sets.
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Summary | |
---|---|
Symbol | SWAP70 |
Name | SWAP switching B-cell complex 70kDa subunit |
Aliases | KIAA0640; SWAP-70; HSPC321; Switch-associated protein 70 |
Chromosomal Location | 11p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SWAP70. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SWAP70 |
Name | SWAP switching B-cell complex 70kDa subunit |
Aliases | KIAA0640; SWAP-70; HSPC321; Switch-associated protein 70 |
Chromosomal Location | 11p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SWAP70. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SWAP70. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SWAP70 |
Name | SWAP switching B-cell complex 70kDa subunit |
Aliases | KIAA0640; SWAP-70; HSPC321; Switch-associated protein 70 |
Chromosomal Location | 11p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SWAP70. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SWAP70 |
Name | SWAP switching B-cell complex 70kDa subunit |
Aliases | KIAA0640; SWAP-70; HSPC321; Switch-associated protein 70 |
Chromosomal Location | 11p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SWAP70 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SWAP70 |
Name | SWAP switching B-cell complex 70kDa subunit |
Aliases | KIAA0640; SWAP-70; HSPC321; Switch-associated protein 70 |
Chromosomal Location | 11p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SWAP70 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |