Summary | |
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Symbol | SYNDIG1 |
Name | synapse differentiation inducing 1 |
Aliases | FLJ14220; IFITMD5; interferon induced transmembrane protein domain containing 5; synapse differentiation ind ...... |
Chromosomal Location | 20p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Single-pass type II membrane protein. Early endosome membrane Single-pass type II membrane protein Cell junction, synapse, postsynaptic cell membrane, postsynaptic density Cell junction, synapse Cell projection, dendrite Cell projection, dendritic spine Note=Shuttles between the cell surface and early endosome membrane. |
Domain |
PF04505 Interferon-induced transmembrane protein |
Function |
May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation. |
Biological Process |
GO:0007416 synapse assembly GO:0044089 positive regulation of cellular component biogenesis GO:0050803 regulation of synapse structure or activity GO:0050807 regulation of synapse organization GO:0050808 synapse organization GO:0051640 organelle localization GO:0051648 vesicle localization GO:0051962 positive regulation of nervous system development GO:0051963 regulation of synapse assembly GO:0051965 positive regulation of synapse assembly GO:0097091 synaptic vesicle clustering GO:0097479 synaptic vesicle localization GO:0099504 synaptic vesicle cycle |
Molecular Function |
GO:0035254 glutamate receptor binding |
Cellular Component |
GO:0005769 early endosome GO:0010008 endosome membrane GO:0014069 postsynaptic density GO:0030425 dendrite GO:0031901 early endosome membrane GO:0043197 dendritic spine GO:0043198 dendritic shaft GO:0044297 cell body GO:0044309 neuron spine GO:0044440 endosomal part GO:0045211 postsynaptic membrane GO:0060076 excitatory synapse GO:0097060 synaptic membrane GO:0098793 presynapse GO:0098794 postsynapse GO:0099572 postsynaptic specialization |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | SYNDIG1 |
Name | synapse differentiation inducing 1 |
Aliases | FLJ14220; IFITMD5; interferon induced transmembrane protein domain containing 5; synapse differentiation ind ...... |
Chromosomal Location | 20p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SYNDIG1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SYNDIG1 |
Name | synapse differentiation inducing 1 |
Aliases | FLJ14220; IFITMD5; interferon induced transmembrane protein domain containing 5; synapse differentiation ind ...... |
Chromosomal Location | 20p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SYNDIG1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | SYNDIG1 |
Name | synapse differentiation inducing 1 |
Aliases | FLJ14220; IFITMD5; interferon induced transmembrane protein domain containing 5; synapse differentiation ind ...... |
Chromosomal Location | 20p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SYNDIG1 in various data sets.
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Points in the above scatter plot represent the mutation difference of SYNDIG1 in various data sets.
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Summary | |
---|---|
Symbol | SYNDIG1 |
Name | synapse differentiation inducing 1 |
Aliases | FLJ14220; IFITMD5; interferon induced transmembrane protein domain containing 5; synapse differentiation ind ...... |
Chromosomal Location | 20p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SYNDIG1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SYNDIG1 |
Name | synapse differentiation inducing 1 |
Aliases | FLJ14220; IFITMD5; interferon induced transmembrane protein domain containing 5; synapse differentiation ind ...... |
Chromosomal Location | 20p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SYNDIG1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SYNDIG1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SYNDIG1 |
Name | synapse differentiation inducing 1 |
Aliases | FLJ14220; IFITMD5; interferon induced transmembrane protein domain containing 5; synapse differentiation ind ...... |
Chromosomal Location | 20p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SYNDIG1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SYNDIG1 |
Name | synapse differentiation inducing 1 |
Aliases | FLJ14220; IFITMD5; interferon induced transmembrane protein domain containing 5; synapse differentiation ind ...... |
Chromosomal Location | 20p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SYNDIG1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SYNDIG1 |
Name | synapse differentiation inducing 1 |
Aliases | FLJ14220; IFITMD5; interferon induced transmembrane protein domain containing 5; synapse differentiation ind ...... |
Chromosomal Location | 20p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SYNDIG1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SYNDIG1 |
Name | synapse differentiation inducing 1 |
Aliases | FLJ14220; IFITMD5; interferon induced transmembrane protein domain containing 5; synapse differentiation ind ...... |
Chromosomal Location | 20p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SYNDIG1 collected from DrugBank database. |
There is no record. |