Summary | |
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Symbol | SYNGR3 |
Name | synaptogyrin 3 |
Aliases | Synaptogyrin-3 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Multi-pass membrane protein Cell junction, synapse Note=Found at the neuromuscular synapses. |
Domain |
PF01284 Membrane-associating domain |
Function |
May play a role in regulated exocytosis. May indirectly regulate the activity of the plasma membrane dopamine transporter SLC6A3 and thereby regulate dopamine transport back from the synaptic cleft into the presynaptic terminal. |
Biological Process |
GO:0021762 substantia nigra development GO:0030901 midbrain development GO:0032409 regulation of transporter activity GO:0032411 positive regulation of transporter activity GO:0048857 neural nucleus development |
Molecular Function |
GO:0042169 SH2 domain binding GO:0047485 protein N-terminus binding |
Cellular Component |
GO:0008021 synaptic vesicle GO:0030133 transport vesicle GO:0030658 transport vesicle membrane GO:0030659 cytoplasmic vesicle membrane GO:0030672 synaptic vesicle membrane GO:0031594 neuromuscular junction GO:0070382 exocytic vesicle GO:0098793 presynapse GO:0099501 exocytic vesicle membrane GO:0099503 secretory vesicle |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | SYNGR3 |
Name | synaptogyrin 3 |
Aliases | Synaptogyrin-3 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SYNGR3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SYNGR3 |
Name | synaptogyrin 3 |
Aliases | Synaptogyrin-3 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SYNGR3 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | SYNGR3 |
Name | synaptogyrin 3 |
Aliases | Synaptogyrin-3 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SYNGR3 in various data sets.
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Points in the above scatter plot represent the mutation difference of SYNGR3 in various data sets.
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Summary | |
---|---|
Symbol | SYNGR3 |
Name | synaptogyrin 3 |
Aliases | Synaptogyrin-3 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SYNGR3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SYNGR3 |
Name | synaptogyrin 3 |
Aliases | Synaptogyrin-3 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SYNGR3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SYNGR3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SYNGR3 |
Name | synaptogyrin 3 |
Aliases | Synaptogyrin-3 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SYNGR3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SYNGR3 |
Name | synaptogyrin 3 |
Aliases | Synaptogyrin-3 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SYNGR3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SYNGR3 |
Name | synaptogyrin 3 |
Aliases | Synaptogyrin-3 |
Chromosomal Location | 16p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SYNGR3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |