Summary | |
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Symbol | SYNPO2 |
Name | synaptopodin 2 |
Aliases | MYOPODIN; genethonin-2; Synaptopodin-2 |
Chromosomal Location | 4q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Cytoplasm Cytoplasm, cytoskeleton Cytoplasm, myofibril, sarcomere, Z line Cell junction, focal adhesion Note=Shuttles between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion. In undifferentiated myoblasts strongly expressed in the nucleus, after induction of myotube differentiation is located to both nucleus and cytoplasm along acting filaments, and in differentiated myotubes is located at the Z lines. Upon stress redistributes from cytoplasm of myoblasts and myotubes to the nucleus. Nuclear import is KPNA2-dependent and promoted by phosphorylation by PKA and/or CaMK2, and inhibition of calcineurin. The nuclear export is XPO1-dependent (By similarity). Localized in a fiber-like pattern, partly overlapping with filamentous actin (PubMed:18371299). ; SUBCELLULAR LOCATION: Isoform 1: Cytoplasm, cytoskeleton Note=Localizes to induced actin bundles with contiguous staining. ; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm, cytoskeleton Note=Localizes to induced actin bundles with punctuate staining. ; SUBCELLULAR LOCATION: Isoform 3: Cytoplasm, cytoskeleton Note=Localizes to induced irregular actin bundles with contiguous and punctuated staining. ; SUBCELLULAR LOCATION: Isoform 4: Cytoplasm, cytoskeleton Note=Localizes to induced actin bundles with punctuate staining. ; SUBCELLULAR LOCATION: Isoform 5: Cytoplasm, cytoskeleton Note=Localizes to induced actin bundles with contiguous staining. |
Domain |
PF00595 PDZ domain (Also known as DHR or GLGF) |
Function |
Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:24005909, PubMed:23225103). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336). ; FUNCTION: Isoform 1: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. ; FUNCTION: Isoform 2: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. ; FUNCTION: Isoform 3: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. ; FUNCTION: Isoform 4: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. ; FUNCTION: Isoform 5: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia (PubMed:22915763, PubMed:25883213). Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro. |
Biological Process |
GO:0007015 actin filament organization GO:0032231 regulation of actin filament bundle assembly GO:0032233 positive regulation of actin filament bundle assembly GO:0032956 regulation of actin cytoskeleton organization GO:0032970 regulation of actin filament-based process GO:0044089 positive regulation of cellular component biogenesis GO:0051017 actin filament bundle assembly GO:0051493 regulation of cytoskeleton organization GO:0051495 positive regulation of cytoskeleton organization GO:0061572 actin filament bundle organization |
Molecular Function |
GO:0003779 actin binding GO:0042805 actinin binding GO:0051371 muscle alpha-actinin binding GO:0051393 alpha-actinin binding GO:0071889 14-3-3 protein binding |
Cellular Component |
GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0015629 actin cytoskeleton GO:0030016 myofibril GO:0030017 sarcomere GO:0030018 Z disc GO:0030055 cell-substrate junction GO:0031674 I band GO:0043292 contractile fiber GO:0044449 contractile fiber part |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | SYNPO2 |
Name | synaptopodin 2 |
Aliases | MYOPODIN; genethonin-2; Synaptopodin-2 |
Chromosomal Location | 4q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SYNPO2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | SYNPO2 |
Name | synaptopodin 2 |
Aliases | MYOPODIN; genethonin-2; Synaptopodin-2 |
Chromosomal Location | 4q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SYNPO2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SYNPO2 |
Name | synaptopodin 2 |
Aliases | MYOPODIN; genethonin-2; Synaptopodin-2 |
Chromosomal Location | 4q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SYNPO2 in various data sets.
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Points in the above scatter plot represent the mutation difference of SYNPO2 in various data sets.
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Summary | |
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Symbol | SYNPO2 |
Name | synaptopodin 2 |
Aliases | MYOPODIN; genethonin-2; Synaptopodin-2 |
Chromosomal Location | 4q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SYNPO2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SYNPO2 |
Name | synaptopodin 2 |
Aliases | MYOPODIN; genethonin-2; Synaptopodin-2 |
Chromosomal Location | 4q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SYNPO2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SYNPO2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SYNPO2 |
Name | synaptopodin 2 |
Aliases | MYOPODIN; genethonin-2; Synaptopodin-2 |
Chromosomal Location | 4q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SYNPO2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SYNPO2 |
Name | synaptopodin 2 |
Aliases | MYOPODIN; genethonin-2; Synaptopodin-2 |
Chromosomal Location | 4q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SYNPO2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SYNPO2 |
Name | synaptopodin 2 |
Aliases | MYOPODIN; genethonin-2; Synaptopodin-2 |
Chromosomal Location | 4q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SYNPO2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |