Summary | |
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Symbol | SYNRG |
Name | synergin, gamma |
Aliases | SYNG; MGC104959; gamma-synergin; adaptor-related protein complex 1 gamma subunit-binding protein 1; AP1GBP1; ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Golgi apparatus, trans-Golgi network membrane Peripheral membrane protein Note=Associates with membranes via the adapter protein complex AP-1. Colocalizes with AP1G1 (By similarity). |
Domain | - |
Function |
May play a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN). May act by linking the adapter protein complex AP-1 to other proteins. |
Biological Process | - |
Molecular Function | - |
Cellular Component |
GO:0005798 Golgi-associated vesicle GO:0012510 trans-Golgi network transport vesicle membrane GO:0030117 membrane coat GO:0030118 clathrin coat GO:0030119 AP-type membrane coat adaptor complex GO:0030120 vesicle coat GO:0030121 AP-1 adaptor complex GO:0030125 clathrin vesicle coat GO:0030130 clathrin coat of trans-Golgi network vesicle GO:0030131 clathrin adaptor complex GO:0030133 transport vesicle GO:0030135 coated vesicle GO:0030136 clathrin-coated vesicle GO:0030140 trans-Golgi network transport vesicle GO:0030658 transport vesicle membrane GO:0030659 cytoplasmic vesicle membrane GO:0030660 Golgi-associated vesicle membrane GO:0030662 coated vesicle membrane GO:0030665 clathrin-coated vesicle membrane GO:0048475 coated membrane |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | SYNRG |
Name | synergin, gamma |
Aliases | SYNG; MGC104959; gamma-synergin; adaptor-related protein complex 1 gamma subunit-binding protein 1; AP1GBP1; ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SYNRG and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SYNRG |
Name | synergin, gamma |
Aliases | SYNG; MGC104959; gamma-synergin; adaptor-related protein complex 1 gamma subunit-binding protein 1; AP1GBP1; ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SYNRG in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SYNRG |
Name | synergin, gamma |
Aliases | SYNG; MGC104959; gamma-synergin; adaptor-related protein complex 1 gamma subunit-binding protein 1; AP1GBP1; ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SYNRG in various data sets.
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Points in the above scatter plot represent the mutation difference of SYNRG in various data sets.
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Summary | |
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Symbol | SYNRG |
Name | synergin, gamma |
Aliases | SYNG; MGC104959; gamma-synergin; adaptor-related protein complex 1 gamma subunit-binding protein 1; AP1GBP1; ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SYNRG. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SYNRG |
Name | synergin, gamma |
Aliases | SYNG; MGC104959; gamma-synergin; adaptor-related protein complex 1 gamma subunit-binding protein 1; AP1GBP1; ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SYNRG. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SYNRG. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SYNRG |
Name | synergin, gamma |
Aliases | SYNG; MGC104959; gamma-synergin; adaptor-related protein complex 1 gamma subunit-binding protein 1; AP1GBP1; ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SYNRG. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SYNRG |
Name | synergin, gamma |
Aliases | SYNG; MGC104959; gamma-synergin; adaptor-related protein complex 1 gamma subunit-binding protein 1; AP1GBP1; ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SYNRG expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | SYNRG |
Name | synergin, gamma |
Aliases | SYNG; MGC104959; gamma-synergin; adaptor-related protein complex 1 gamma subunit-binding protein 1; AP1GBP1; ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SYNRG and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SYNRG |
Name | synergin, gamma |
Aliases | SYNG; MGC104959; gamma-synergin; adaptor-related protein complex 1 gamma subunit-binding protein 1; AP1GBP1; ...... |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SYNRG collected from DrugBank database. |
There is no record. |