Summary | |
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Symbol | SYTL2 |
Name | synaptotagmin-like 2 |
Aliases | FLJ20163; FLJ21219; KIAA1597; exophilin-4; CHR11SYT; SLP2; SGA72M; MGC102768; PPP1R151; chromosome 11 synapt ...... |
Chromosomal Location | 11q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Cytoplasm Cell membrane Note=Recruited on vesicular structures in cytotoxic T-lymphocytes (CTL) by RAB27A. ; SUBCELLULAR LOCATION: Isoform 4: Cell membrane Note=In the pancreatic alpha cells distributed in both peripheral and anterior regions. Localizes on the glucagon granules in the cell periphery. |
Domain |
PF00168 C2 domain |
Function |
Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. |
Biological Process |
GO:0006887 exocytosis GO:0006904 vesicle docking involved in exocytosis GO:0006906 vesicle fusion GO:0007009 plasma membrane organization GO:0007589 body fluid secretion GO:0010921 regulation of phosphatase activity GO:0010923 negative regulation of phosphatase activity GO:0016050 vesicle organization GO:0016311 dephosphorylation GO:0022406 membrane docking GO:0032941 secretion by tissue GO:0035303 regulation of dephosphorylation GO:0035305 negative regulation of dephosphorylation GO:0044801 single-organism membrane fusion GO:0048278 vesicle docking GO:0048284 organelle fusion GO:0050878 regulation of body fluid levels GO:0051047 positive regulation of secretion GO:0051346 negative regulation of hydrolase activity GO:0061025 membrane fusion GO:0070254 mucus secretion GO:0070255 regulation of mucus secretion GO:0070257 positive regulation of mucus secretion GO:0072657 protein localization to membrane GO:0072659 protein localization to plasma membrane GO:0090174 organelle membrane fusion GO:1990778 protein localization to cell periphery |
Molecular Function |
GO:0000149 SNARE binding GO:0001786 phosphatidylserine binding GO:0005543 phospholipid binding GO:0005544 calcium-dependent phospholipid binding GO:0005546 phosphatidylinositol-4,5-bisphosphate binding GO:0017016 Ras GTPase binding GO:0017137 Rab GTPase binding GO:0019902 phosphatase binding GO:0019905 syntaxin binding GO:0030276 clathrin binding GO:0031267 small GTPase binding GO:0035091 phosphatidylinositol binding GO:0042043 neurexin family protein binding GO:0051020 GTPase binding GO:0072341 modified amino acid binding GO:1901981 phosphatidylinositol phosphate binding GO:1902936 phosphatidylinositol bisphosphate binding |
Cellular Component |
GO:0019897 extrinsic component of plasma membrane GO:0019898 extrinsic component of membrane GO:0030133 transport vesicle GO:0042470 melanosome GO:0048770 pigment granule GO:0070382 exocytic vesicle GO:0099503 secretory vesicle |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | SYTL2 |
Name | synaptotagmin-like 2 |
Aliases | FLJ20163; FLJ21219; KIAA1597; exophilin-4; CHR11SYT; SLP2; SGA72M; MGC102768; PPP1R151; chromosome 11 synapt ...... |
Chromosomal Location | 11q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SYTL2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SYTL2 |
Name | synaptotagmin-like 2 |
Aliases | FLJ20163; FLJ21219; KIAA1597; exophilin-4; CHR11SYT; SLP2; SGA72M; MGC102768; PPP1R151; chromosome 11 synapt ...... |
Chromosomal Location | 11q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SYTL2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SYTL2 |
Name | synaptotagmin-like 2 |
Aliases | FLJ20163; FLJ21219; KIAA1597; exophilin-4; CHR11SYT; SLP2; SGA72M; MGC102768; PPP1R151; chromosome 11 synapt ...... |
Chromosomal Location | 11q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SYTL2 in various data sets.
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Points in the above scatter plot represent the mutation difference of SYTL2 in various data sets.
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Summary | |
---|---|
Symbol | SYTL2 |
Name | synaptotagmin-like 2 |
Aliases | FLJ20163; FLJ21219; KIAA1597; exophilin-4; CHR11SYT; SLP2; SGA72M; MGC102768; PPP1R151; chromosome 11 synapt ...... |
Chromosomal Location | 11q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SYTL2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SYTL2 |
Name | synaptotagmin-like 2 |
Aliases | FLJ20163; FLJ21219; KIAA1597; exophilin-4; CHR11SYT; SLP2; SGA72M; MGC102768; PPP1R151; chromosome 11 synapt ...... |
Chromosomal Location | 11q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SYTL2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SYTL2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SYTL2 |
Name | synaptotagmin-like 2 |
Aliases | FLJ20163; FLJ21219; KIAA1597; exophilin-4; CHR11SYT; SLP2; SGA72M; MGC102768; PPP1R151; chromosome 11 synapt ...... |
Chromosomal Location | 11q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SYTL2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SYTL2 |
Name | synaptotagmin-like 2 |
Aliases | FLJ20163; FLJ21219; KIAA1597; exophilin-4; CHR11SYT; SLP2; SGA72M; MGC102768; PPP1R151; chromosome 11 synapt ...... |
Chromosomal Location | 11q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SYTL2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SYTL2 |
Name | synaptotagmin-like 2 |
Aliases | FLJ20163; FLJ21219; KIAA1597; exophilin-4; CHR11SYT; SLP2; SGA72M; MGC102768; PPP1R151; chromosome 11 synapt ...... |
Chromosomal Location | 11q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SYTL2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SYTL2 |
Name | synaptotagmin-like 2 |
Aliases | FLJ20163; FLJ21219; KIAA1597; exophilin-4; CHR11SYT; SLP2; SGA72M; MGC102768; PPP1R151; chromosome 11 synapt ...... |
Chromosomal Location | 11q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SYTL2 collected from DrugBank database. |
There is no record. |