Summary | |
---|---|
Symbol | TAC3 |
Name | tachykinin 3 |
Aliases | ZNEUROK1; NKB; preprotachykinin-B; NKNB; neuromedin K; neurokinin beta; HH10; PRO1155; gamma tachykinin 3; n ...... |
Chromosomal Location | 12q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF03823 Neurokinin B |
Function |
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). Is a critical central regulator of gonadal function. |
Biological Process |
GO:0007217 tachykinin receptor signaling pathway GO:0007218 neuropeptide signaling pathway GO:0007565 female pregnancy GO:0044706 multi-multicellular organism process |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-416476: G alpha (q) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-375276: Peptide ligand-binding receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR R-HSA-380095: Tachykinin receptors bind tachykinins |
Summary | |
---|---|
Symbol | TAC3 |
Name | tachykinin 3 |
Aliases | ZNEUROK1; NKB; preprotachykinin-B; NKNB; neuromedin K; neurokinin beta; HH10; PRO1155; gamma tachykinin 3; n ...... |
Chromosomal Location | 12q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TAC3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TAC3 |
Name | tachykinin 3 |
Aliases | ZNEUROK1; NKB; preprotachykinin-B; NKNB; neuromedin K; neurokinin beta; HH10; PRO1155; gamma tachykinin 3; n ...... |
Chromosomal Location | 12q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of TAC3 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | TAC3 |
Name | tachykinin 3 |
Aliases | ZNEUROK1; NKB; preprotachykinin-B; NKNB; neuromedin K; neurokinin beta; HH10; PRO1155; gamma tachykinin 3; n ...... |
Chromosomal Location | 12q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TAC3 in various data sets.
|
Points in the above scatter plot represent the mutation difference of TAC3 in various data sets.
|
Summary | |
---|---|
Symbol | TAC3 |
Name | tachykinin 3 |
Aliases | ZNEUROK1; NKB; preprotachykinin-B; NKNB; neuromedin K; neurokinin beta; HH10; PRO1155; gamma tachykinin 3; n ...... |
Chromosomal Location | 12q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TAC3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TAC3 |
Name | tachykinin 3 |
Aliases | ZNEUROK1; NKB; preprotachykinin-B; NKNB; neuromedin K; neurokinin beta; HH10; PRO1155; gamma tachykinin 3; n ...... |
Chromosomal Location | 12q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TAC3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TAC3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TAC3 |
Name | tachykinin 3 |
Aliases | ZNEUROK1; NKB; preprotachykinin-B; NKNB; neuromedin K; neurokinin beta; HH10; PRO1155; gamma tachykinin 3; n ...... |
Chromosomal Location | 12q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TAC3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TAC3 |
Name | tachykinin 3 |
Aliases | ZNEUROK1; NKB; preprotachykinin-B; NKNB; neuromedin K; neurokinin beta; HH10; PRO1155; gamma tachykinin 3; n ...... |
Chromosomal Location | 12q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TAC3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TAC3 |
Name | tachykinin 3 |
Aliases | ZNEUROK1; NKB; preprotachykinin-B; NKNB; neuromedin K; neurokinin beta; HH10; PRO1155; gamma tachykinin 3; n ...... |
Chromosomal Location | 12q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TAC3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TAC3 |
Name | tachykinin 3 |
Aliases | ZNEUROK1; NKB; preprotachykinin-B; NKNB; neuromedin K; neurokinin beta; HH10; PRO1155; gamma tachykinin 3; n ...... |
Chromosomal Location | 12q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TAC3 collected from DrugBank database. |
Details on drugs targeting TAC3.
|