Browse TACR3

Summary
SymbolTACR3
Nametachykinin receptor 3
Aliases NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ......
Chromosomal Location4q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane; Multi-pass membrane protein.
Domain PF00001 7 transmembrane receptor (rhodopsin family)
Function

This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.

> Gene Ontology
 
Biological Process GO:0002027 regulation of heart rate
GO:0003012 muscle system process
GO:0003013 circulatory system process
GO:0003015 heart process
GO:0006584 catecholamine metabolic process
GO:0006936 muscle contraction
GO:0006937 regulation of muscle contraction
GO:0006939 smooth muscle contraction
GO:0006940 regulation of smooth muscle contraction
GO:0006970 response to osmotic stress
GO:0006972 hyperosmotic response
GO:0007217 tachykinin receptor signaling pathway
GO:0007568 aging
GO:0007631 feeding behavior
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0008217 regulation of blood pressure
GO:0009308 amine metabolic process
GO:0009651 response to salt stress
GO:0009712 catechol-containing compound metabolic process
GO:0010460 positive regulation of heart rate
GO:0014072 response to isoquinoline alkaloid
GO:0018958 phenol-containing compound metabolic process
GO:0032355 response to estradiol
GO:0033238 regulation of cellular amine metabolic process
GO:0042053 regulation of dopamine metabolic process
GO:0042069 regulation of catecholamine metabolic process
GO:0042220 response to cocaine
GO:0042417 dopamine metabolic process
GO:0042538 hyperosmotic salinity response
GO:0043278 response to morphine
GO:0043279 response to alkaloid
GO:0044057 regulation of system process
GO:0044106 cellular amine metabolic process
GO:0045777 positive regulation of blood pressure
GO:0045823 positive regulation of heart contraction
GO:0045933 positive regulation of muscle contraction
GO:0045987 positive regulation of smooth muscle contraction
GO:0050795 regulation of behavior
GO:0060047 heart contraction
GO:0060259 regulation of feeding behavior
GO:0070471 uterine smooth muscle contraction
GO:0070472 regulation of uterine smooth muscle contraction
GO:0070474 positive regulation of uterine smooth muscle contraction
GO:0090257 regulation of muscle system process
GO:1901615 organic hydroxy compound metabolic process
GO:1903522 regulation of blood circulation
GO:1903524 positive regulation of blood circulation
Molecular Function GO:0001653 peptide receptor activity
GO:0004995 tachykinin receptor activity
GO:0008188 neuropeptide receptor activity
GO:0008528 G-protein coupled peptide receptor activity
Cellular Component GO:0031252 cell leading edge
GO:0031253 cell projection membrane
GO:0031256 leading edge membrane
GO:0032589 neuron projection membrane
GO:0032590 dendrite membrane
GO:0032809 neuronal cell body membrane
GO:0043025 neuronal cell body
GO:0044297 cell body
GO:0044298 cell body membrane
> KEGG and Reactome Pathway
 
KEGG hsa04020 Calcium signaling pathway
hsa04080 Neuroactive ligand-receptor interaction
Reactome R-HSA-373076: Class A/1 (Rhodopsin-like receptors)
R-HSA-416476: G alpha (q) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-500792: GPCR ligand binding
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-375276: Peptide ligand-binding receptors
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
R-HSA-380095: Tachykinin receptors bind tachykinins
Summary
SymbolTACR3
Nametachykinin receptor 3
Aliases NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ......
Chromosomal Location4q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TACR3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolTACR3
Nametachykinin receptor 3
Aliases NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ......
Chromosomal Location4q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TACR3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTACR3
Nametachykinin receptor 3
Aliases NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ......
Chromosomal Location4q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TACR3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1150.839
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2970.784
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.1210.918
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.8150.0108
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TACR3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141714.3014.30.196
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103200201
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.16.84.30.443
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.18.52.60.702
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.317.6-3.31
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86016.7-16.70.429
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131123.118.24.91
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTACR3
Nametachykinin receptor 3
Aliases NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ......
Chromosomal Location4q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TACR3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTACR3
Nametachykinin receptor 3
Aliases NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ......
Chromosomal Location4q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TACR3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TACR3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTACR3
Nametachykinin receptor 3
Aliases NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ......
Chromosomal Location4q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TACR3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTACR3
Nametachykinin receptor 3
Aliases NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ......
Chromosomal Location4q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TACR3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTACR3
Nametachykinin receptor 3
Aliases NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ......
Chromosomal Location4q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TACR3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTACR3
Nametachykinin receptor 3
Aliases NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ......
Chromosomal Location4q25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TACR3 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting TACR3.
ID Name Drug Type Targets #Targets
DB04872OsanetantSmall MoleculeTACR31
DB06429TalnetantSmall MoleculeTACR31