Summary | |
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Symbol | TACR3 |
Name | tachykinin receptor 3 |
Aliases | NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ...... |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF00001 7 transmembrane receptor (rhodopsin family) |
Function |
This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P. |
Biological Process |
GO:0002027 regulation of heart rate GO:0003012 muscle system process GO:0003013 circulatory system process GO:0003015 heart process GO:0006584 catecholamine metabolic process GO:0006936 muscle contraction GO:0006937 regulation of muscle contraction GO:0006939 smooth muscle contraction GO:0006940 regulation of smooth muscle contraction GO:0006970 response to osmotic stress GO:0006972 hyperosmotic response GO:0007217 tachykinin receptor signaling pathway GO:0007568 aging GO:0007631 feeding behavior GO:0008015 blood circulation GO:0008016 regulation of heart contraction GO:0008217 regulation of blood pressure GO:0009308 amine metabolic process GO:0009651 response to salt stress GO:0009712 catechol-containing compound metabolic process GO:0010460 positive regulation of heart rate GO:0014072 response to isoquinoline alkaloid GO:0018958 phenol-containing compound metabolic process GO:0032355 response to estradiol GO:0033238 regulation of cellular amine metabolic process GO:0042053 regulation of dopamine metabolic process GO:0042069 regulation of catecholamine metabolic process GO:0042220 response to cocaine GO:0042417 dopamine metabolic process GO:0042538 hyperosmotic salinity response GO:0043278 response to morphine GO:0043279 response to alkaloid GO:0044057 regulation of system process GO:0044106 cellular amine metabolic process GO:0045777 positive regulation of blood pressure GO:0045823 positive regulation of heart contraction GO:0045933 positive regulation of muscle contraction GO:0045987 positive regulation of smooth muscle contraction GO:0050795 regulation of behavior GO:0060047 heart contraction GO:0060259 regulation of feeding behavior GO:0070471 uterine smooth muscle contraction GO:0070472 regulation of uterine smooth muscle contraction GO:0070474 positive regulation of uterine smooth muscle contraction GO:0090257 regulation of muscle system process GO:1901615 organic hydroxy compound metabolic process GO:1903522 regulation of blood circulation GO:1903524 positive regulation of blood circulation |
Molecular Function |
GO:0001653 peptide receptor activity GO:0004995 tachykinin receptor activity GO:0008188 neuropeptide receptor activity GO:0008528 G-protein coupled peptide receptor activity |
Cellular Component |
GO:0031252 cell leading edge GO:0031253 cell projection membrane GO:0031256 leading edge membrane GO:0032589 neuron projection membrane GO:0032590 dendrite membrane GO:0032809 neuronal cell body membrane GO:0043025 neuronal cell body GO:0044297 cell body GO:0044298 cell body membrane |
KEGG |
hsa04020 Calcium signaling pathway hsa04080 Neuroactive ligand-receptor interaction |
Reactome |
R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-416476: G alpha (q) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-375276: Peptide ligand-binding receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR R-HSA-380095: Tachykinin receptors bind tachykinins |
Summary | |
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Symbol | TACR3 |
Name | tachykinin receptor 3 |
Aliases | NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ...... |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TACR3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TACR3 |
Name | tachykinin receptor 3 |
Aliases | NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ...... |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TACR3 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | TACR3 |
Name | tachykinin receptor 3 |
Aliases | NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ...... |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TACR3 in various data sets.
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Points in the above scatter plot represent the mutation difference of TACR3 in various data sets.
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Summary | |
---|---|
Symbol | TACR3 |
Name | tachykinin receptor 3 |
Aliases | NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ...... |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TACR3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TACR3 |
Name | tachykinin receptor 3 |
Aliases | NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ...... |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TACR3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TACR3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TACR3 |
Name | tachykinin receptor 3 |
Aliases | NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ...... |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TACR3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TACR3 |
Name | tachykinin receptor 3 |
Aliases | NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ...... |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TACR3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TACR3 |
Name | tachykinin receptor 3 |
Aliases | NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ...... |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TACR3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TACR3 |
Name | tachykinin receptor 3 |
Aliases | NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ...... |
Chromosomal Location | 4q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TACR3 collected from DrugBank database. |
Details on drugs targeting TACR3.
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