Summary | |
---|---|
Symbol | TAF1 |
Name | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa |
Aliases | TAFII250; DYT3/TAF1; BA2R; CCG1; CCGS; DYT3; TATA box binding protein (TBP)-associated factor, RNA polymeras ...... |
Chromosomal Location | Xq13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF00439 Bromodomain PF12157 Protein of unknown function (DUF3591) PF09247 TATA box-binding protein binding |
Function |
Largest component and core scaffold of the TFIID basal transcription factor complex (PubMed:25412659, PubMed:27007846). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity (PubMed:25412659). Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607). Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300). |
Biological Process |
GO:0006352 DNA-templated transcription, initiation GO:0006354 DNA-templated transcription, elongation GO:0006367 transcription initiation from RNA polymerase II promoter GO:0006368 transcription elongation from RNA polymerase II promoter GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0009894 regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0010498 proteasomal protein catabolic process GO:0016570 histone modification GO:0016573 histone acetylation GO:0018105 peptidyl-serine phosphorylation GO:0018107 peptidyl-threonine phosphorylation GO:0018205 peptidyl-lysine modification GO:0018209 peptidyl-serine modification GO:0018210 peptidyl-threonine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0031329 regulation of cellular catabolic process GO:0031331 positive regulation of cellular catabolic process GO:0031334 positive regulation of protein complex assembly GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0042176 regulation of protein catabolic process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043254 regulation of protein complex assembly GO:0043543 protein acylation GO:0044089 positive regulation of cellular component biogenesis GO:0045732 positive regulation of protein catabolic process GO:0045862 positive regulation of proteolysis GO:0046777 protein autophosphorylation GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly GO:0060260 regulation of transcription initiation from RNA polymerase II promoter GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter GO:0061136 regulation of proteasomal protein catabolic process GO:0065004 protein-DNA complex assembly GO:0070897 DNA-templated transcriptional preinitiation complex assembly GO:0071824 protein-DNA complex subunit organization GO:0072331 signal transduction by p53 class mediator GO:1901796 regulation of signal transduction by p53 class mediator GO:1901800 positive regulation of proteasomal protein catabolic process GO:1903050 regulation of proteolysis involved in cellular protein catabolic process GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process GO:1903362 regulation of cellular protein catabolic process GO:1903364 positive regulation of cellular protein catabolic process GO:2000142 regulation of DNA-templated transcription, initiation GO:2000144 positive regulation of DNA-templated transcription, initiation |
Molecular Function |
GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly GO:0001132 RNA polymerase II transcription factor activity, TBP-class protein binding GO:0002039 p53 binding GO:0003713 transcription coactivator activity GO:0004402 histone acetyltransferase activity GO:0004674 protein serine/threonine kinase activity GO:0008080 N-acetyltransferase activity GO:0008134 transcription factor binding GO:0016407 acetyltransferase activity GO:0016410 N-acyltransferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0017025 TBP-class protein binding GO:0034212 peptide N-acetyltransferase activity GO:0042393 histone binding GO:0061733 peptide-lysine-N-acetyltransferase activity GO:0070577 lysine-acetylated histone binding |
Cellular Component |
GO:0000428 DNA-directed RNA polymerase complex GO:0005667 transcription factor complex GO:0005669 transcription factor TFIID complex GO:0016591 DNA-directed RNA polymerase II, holoenzyme GO:0030880 RNA polymerase complex GO:0034708 methyltransferase complex GO:0035097 histone methyltransferase complex GO:0044665 MLL1/2 complex GO:0044798 nuclear transcription factor complex GO:0055029 nuclear DNA-directed RNA polymerase complex GO:0061695 transferase complex, transferring phosphorus-containing groups GO:0071339 MLL1 complex GO:0090575 RNA polymerase II transcription factor complex |
KEGG |
hsa03022 Basal transcription factors |
Reactome |
R-HSA-1643685: Disease R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-162906: HIV Infection R-HSA-162587: HIV Life Cycle R-HSA-167161: HIV Transcription Initiation R-HSA-5663205: Infectious disease R-HSA-162599: Late Phase of HIV Life Cycle R-HSA-167162: RNA Polymerase II HIV Promoter Escape R-HSA-674695: RNA Polymerase II Pre-transcription Events R-HSA-73776: RNA Polymerase II Promoter Escape R-HSA-73857: RNA Polymerase II Transcription R-HSA-75953: RNA Polymerase II Transcription Initiation R-HSA-76042: RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-73779: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804756: Regulation of TP53 Activity through Phosphorylation R-HSA-167172: Transcription of the HIV genome R-HSA-3700989: Transcriptional Regulation by TP53 |
Summary | |
---|---|
Symbol | TAF1 |
Name | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa |
Aliases | TAFII250; DYT3/TAF1; BA2R; CCG1; CCGS; DYT3; TATA box binding protein (TBP)-associated factor, RNA polymeras ...... |
Chromosomal Location | Xq13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TAF1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TAF1 |
Name | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa |
Aliases | TAFII250; DYT3/TAF1; BA2R; CCG1; CCGS; DYT3; TATA box binding protein (TBP)-associated factor, RNA polymeras ...... |
Chromosomal Location | Xq13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of TAF1 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | TAF1 |
Name | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa |
Aliases | TAFII250; DYT3/TAF1; BA2R; CCG1; CCGS; DYT3; TATA box binding protein (TBP)-associated factor, RNA polymeras ...... |
Chromosomal Location | Xq13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TAF1 in various data sets.
|
Points in the above scatter plot represent the mutation difference of TAF1 in various data sets.
|
Summary | |
---|---|
Symbol | TAF1 |
Name | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa |
Aliases | TAFII250; DYT3/TAF1; BA2R; CCG1; CCGS; DYT3; TATA box binding protein (TBP)-associated factor, RNA polymeras ...... |
Chromosomal Location | Xq13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TAF1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TAF1 |
Name | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa |
Aliases | TAFII250; DYT3/TAF1; BA2R; CCG1; CCGS; DYT3; TATA box binding protein (TBP)-associated factor, RNA polymeras ...... |
Chromosomal Location | Xq13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TAF1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TAF1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TAF1 |
Name | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa |
Aliases | TAFII250; DYT3/TAF1; BA2R; CCG1; CCGS; DYT3; TATA box binding protein (TBP)-associated factor, RNA polymeras ...... |
Chromosomal Location | Xq13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TAF1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TAF1 |
Name | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa |
Aliases | TAFII250; DYT3/TAF1; BA2R; CCG1; CCGS; DYT3; TATA box binding protein (TBP)-associated factor, RNA polymeras ...... |
Chromosomal Location | Xq13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TAF1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TAF1 |
Name | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa |
Aliases | TAFII250; DYT3/TAF1; BA2R; CCG1; CCGS; DYT3; TATA box binding protein (TBP)-associated factor, RNA polymeras ...... |
Chromosomal Location | Xq13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TAF1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TAF1 |
Name | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa |
Aliases | TAFII250; DYT3/TAF1; BA2R; CCG1; CCGS; DYT3; TATA box binding protein (TBP)-associated factor, RNA polymeras ...... |
Chromosomal Location | Xq13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TAF1 collected from DrugBank database. |
There is no record. |