Summary | |
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Symbol | TAF1L |
Name | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like |
Aliases | TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa; TAF(II)210; TAF2A2; T ...... |
Chromosomal Location | 9p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF00439 Bromodomain PF12157 Protein of unknown function (DUF3591) PF09247 TATA box-binding protein binding |
Function |
May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced. |
Biological Process |
GO:0006352 DNA-templated transcription, initiation GO:0006354 DNA-templated transcription, elongation GO:0006367 transcription initiation from RNA polymerase II promoter GO:0006368 transcription elongation from RNA polymerase II promoter GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0007126 meiotic nuclear division GO:0007140 male meiosis GO:0016570 histone modification GO:0016573 histone acetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0043543 protein acylation GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly GO:0051321 meiotic cell cycle GO:0065004 protein-DNA complex assembly GO:0070897 DNA-templated transcriptional preinitiation complex assembly GO:0071824 protein-DNA complex subunit organization GO:0072331 signal transduction by p53 class mediator GO:1901796 regulation of signal transduction by p53 class mediator GO:1903046 meiotic cell cycle process |
Molecular Function |
GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly GO:0001132 RNA polymerase II transcription factor activity, TBP-class protein binding GO:0004402 histone acetyltransferase activity GO:0004674 protein serine/threonine kinase activity GO:0008080 N-acetyltransferase activity GO:0008134 transcription factor binding GO:0016407 acetyltransferase activity GO:0016410 N-acyltransferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0017025 TBP-class protein binding GO:0034212 peptide N-acetyltransferase activity GO:0042393 histone binding GO:0061733 peptide-lysine-N-acetyltransferase activity GO:0070577 lysine-acetylated histone binding |
Cellular Component |
GO:0000428 DNA-directed RNA polymerase complex GO:0005667 transcription factor complex GO:0005669 transcription factor TFIID complex GO:0016591 DNA-directed RNA polymerase II, holoenzyme GO:0030880 RNA polymerase complex GO:0044798 nuclear transcription factor complex GO:0055029 nuclear DNA-directed RNA polymerase complex GO:0061695 transferase complex, transferring phosphorus-containing groups GO:0090575 RNA polymerase II transcription factor complex |
KEGG |
hsa03022 Basal transcription factors |
Reactome |
R-HSA-1643685: Disease R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-162906: HIV Infection R-HSA-162587: HIV Life Cycle R-HSA-167161: HIV Transcription Initiation R-HSA-5663205: Infectious disease R-HSA-162599: Late Phase of HIV Life Cycle R-HSA-167162: RNA Polymerase II HIV Promoter Escape R-HSA-674695: RNA Polymerase II Pre-transcription Events R-HSA-73776: RNA Polymerase II Promoter Escape R-HSA-73857: RNA Polymerase II Transcription R-HSA-75953: RNA Polymerase II Transcription Initiation R-HSA-76042: RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-73779: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804756: Regulation of TP53 Activity through Phosphorylation R-HSA-167172: Transcription of the HIV genome R-HSA-3700989: Transcriptional Regulation by TP53 |
Summary | |
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Symbol | TAF1L |
Name | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like |
Aliases | TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa; TAF(II)210; TAF2A2; T ...... |
Chromosomal Location | 9p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TAF1L and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TAF1L |
Name | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like |
Aliases | TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa; TAF(II)210; TAF2A2; T ...... |
Chromosomal Location | 9p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TAF1L in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TAF1L |
Name | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like |
Aliases | TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa; TAF(II)210; TAF2A2; T ...... |
Chromosomal Location | 9p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TAF1L in various data sets.
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Points in the above scatter plot represent the mutation difference of TAF1L in various data sets.
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Summary | |
---|---|
Symbol | TAF1L |
Name | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like |
Aliases | TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa; TAF(II)210; TAF2A2; T ...... |
Chromosomal Location | 9p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TAF1L. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TAF1L |
Name | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like |
Aliases | TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa; TAF(II)210; TAF2A2; T ...... |
Chromosomal Location | 9p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TAF1L. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TAF1L. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TAF1L |
Name | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like |
Aliases | TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa; TAF(II)210; TAF2A2; T ...... |
Chromosomal Location | 9p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TAF1L. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TAF1L |
Name | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like |
Aliases | TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa; TAF(II)210; TAF2A2; T ...... |
Chromosomal Location | 9p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TAF1L expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TAF1L |
Name | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like |
Aliases | TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa; TAF(II)210; TAF2A2; T ...... |
Chromosomal Location | 9p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TAF1L and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TAF1L |
Name | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like |
Aliases | TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa; TAF(II)210; TAF2A2; T ...... |
Chromosomal Location | 9p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TAF1L collected from DrugBank database. |
There is no record. |