Summary | |
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Symbol | TAF3 |
Name | TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa |
Aliases | TAF140; TAFII140; TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140 kD; TAFII-14 ...... |
Chromosomal Location | 10p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF07524 Bromodomain associated PF00628 PHD-finger |
Function |
Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process. |
Biological Process |
GO:0006352 DNA-templated transcription, initiation GO:0006354 DNA-templated transcription, elongation GO:0006367 transcription initiation from RNA polymerase II promoter GO:0006368 transcription elongation from RNA polymerase II promoter GO:0032507 maintenance of protein location in cell GO:0034504 protein localization to nucleus GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0045185 maintenance of protein location GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051235 maintenance of location GO:0051457 maintenance of protein location in nucleus GO:0051651 maintenance of location in cell GO:0072331 signal transduction by p53 class mediator GO:0072595 maintenance of protein localization in organelle GO:1901796 regulation of signal transduction by p53 class mediator |
Molecular Function |
GO:0002039 p53 binding |
Cellular Component |
GO:0000428 DNA-directed RNA polymerase complex GO:0005667 transcription factor complex GO:0005669 transcription factor TFIID complex GO:0016591 DNA-directed RNA polymerase II, holoenzyme GO:0030880 RNA polymerase complex GO:0044798 nuclear transcription factor complex GO:0055029 nuclear DNA-directed RNA polymerase complex GO:0061695 transferase complex, transferring phosphorus-containing groups GO:0090575 RNA polymerase II transcription factor complex |
KEGG |
hsa03022 Basal transcription factors |
Reactome |
R-HSA-1643685: Disease R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-162906: HIV Infection R-HSA-162587: HIV Life Cycle R-HSA-167161: HIV Transcription Initiation R-HSA-5663205: Infectious disease R-HSA-162599: Late Phase of HIV Life Cycle R-HSA-167162: RNA Polymerase II HIV Promoter Escape R-HSA-674695: RNA Polymerase II Pre-transcription Events R-HSA-73776: RNA Polymerase II Promoter Escape R-HSA-73857: RNA Polymerase II Transcription R-HSA-75953: RNA Polymerase II Transcription Initiation R-HSA-76042: RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-73779: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804756: Regulation of TP53 Activity through Phosphorylation R-HSA-167172: Transcription of the HIV genome R-HSA-3700989: Transcriptional Regulation by TP53 |
Summary | |
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Symbol | TAF3 |
Name | TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa |
Aliases | TAF140; TAFII140; TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140 kD; TAFII-14 ...... |
Chromosomal Location | 10p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TAF3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TAF3 |
Name | TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa |
Aliases | TAF140; TAFII140; TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140 kD; TAFII-14 ...... |
Chromosomal Location | 10p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TAF3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TAF3 |
Name | TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa |
Aliases | TAF140; TAFII140; TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140 kD; TAFII-14 ...... |
Chromosomal Location | 10p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TAF3 in various data sets.
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Points in the above scatter plot represent the mutation difference of TAF3 in various data sets.
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Summary | |
---|---|
Symbol | TAF3 |
Name | TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa |
Aliases | TAF140; TAFII140; TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140 kD; TAFII-14 ...... |
Chromosomal Location | 10p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TAF3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TAF3 |
Name | TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa |
Aliases | TAF140; TAFII140; TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140 kD; TAFII-14 ...... |
Chromosomal Location | 10p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TAF3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TAF3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TAF3 |
Name | TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa |
Aliases | TAF140; TAFII140; TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140 kD; TAFII-14 ...... |
Chromosomal Location | 10p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TAF3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TAF3 |
Name | TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa |
Aliases | TAF140; TAFII140; TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140 kD; TAFII-14 ...... |
Chromosomal Location | 10p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TAF3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TAF3 |
Name | TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa |
Aliases | TAF140; TAFII140; TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140 kD; TAFII-14 ...... |
Chromosomal Location | 10p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TAF3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TAF3 |
Name | TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa |
Aliases | TAF140; TAFII140; TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140 kD; TAFII-14 ...... |
Chromosomal Location | 10p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TAF3 collected from DrugBank database. |
There is no record. |