Summary | |
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Symbol | TAF5L |
Name | TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa |
Aliases | PAF65B; PCAF associated factor 65 beta; TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-assoc ...... |
Chromosomal Location | 1q42.11-q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF04494 WD40 associated region in TFIID subunit PF00400 WD domain |
Function |
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. |
Biological Process |
GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0016570 histone modification GO:0016573 histone acetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0043543 protein acylation GO:0043966 histone H3 acetylation |
Molecular Function |
GO:0003713 transcription coactivator activity GO:0004402 histone acetyltransferase activity GO:0008080 N-acetyltransferase activity GO:0016407 acetyltransferase activity GO:0016410 N-acyltransferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0034212 peptide N-acetyltransferase activity GO:0061733 peptide-lysine-N-acetyltransferase activity |
Cellular Component |
GO:0000123 histone acetyltransferase complex GO:0000428 DNA-directed RNA polymerase complex GO:0005667 transcription factor complex GO:0016591 DNA-directed RNA polymerase II, holoenzyme GO:0030880 RNA polymerase complex GO:0030914 STAGA complex GO:0031248 protein acetyltransferase complex GO:0033276 transcription factor TFTC complex GO:0044798 nuclear transcription factor complex GO:0055029 nuclear DNA-directed RNA polymerase complex GO:0061695 transferase complex, transferring phosphorus-containing groups GO:0070461 SAGA-type complex GO:0090575 RNA polymerase II transcription factor complex GO:1902493 acetyltransferase complex |
KEGG |
hsa03022 Basal transcription factors |
Reactome |
R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214847: HATs acetylate histones |
Summary | |
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Symbol | TAF5L |
Name | TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa |
Aliases | PAF65B; PCAF associated factor 65 beta; TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-assoc ...... |
Chromosomal Location | 1q42.11-q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TAF5L and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TAF5L |
Name | TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa |
Aliases | PAF65B; PCAF associated factor 65 beta; TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-assoc ...... |
Chromosomal Location | 1q42.11-q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TAF5L in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TAF5L |
Name | TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa |
Aliases | PAF65B; PCAF associated factor 65 beta; TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-assoc ...... |
Chromosomal Location | 1q42.11-q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TAF5L in various data sets.
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Points in the above scatter plot represent the mutation difference of TAF5L in various data sets.
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Summary | |
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Symbol | TAF5L |
Name | TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa |
Aliases | PAF65B; PCAF associated factor 65 beta; TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-assoc ...... |
Chromosomal Location | 1q42.11-q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TAF5L. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TAF5L |
Name | TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa |
Aliases | PAF65B; PCAF associated factor 65 beta; TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-assoc ...... |
Chromosomal Location | 1q42.11-q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TAF5L. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TAF5L. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TAF5L |
Name | TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa |
Aliases | PAF65B; PCAF associated factor 65 beta; TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-assoc ...... |
Chromosomal Location | 1q42.11-q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TAF5L. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TAF5L |
Name | TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa |
Aliases | PAF65B; PCAF associated factor 65 beta; TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-assoc ...... |
Chromosomal Location | 1q42.11-q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TAF5L expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TAF5L |
Name | TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa |
Aliases | PAF65B; PCAF associated factor 65 beta; TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-assoc ...... |
Chromosomal Location | 1q42.11-q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TAF5L and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TAF5L |
Name | TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa |
Aliases | PAF65B; PCAF associated factor 65 beta; TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-assoc ...... |
Chromosomal Location | 1q42.11-q42.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TAF5L collected from DrugBank database. |
There is no record. |