Browse TAF7

Summary
SymbolTAF7
NameTAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
Aliases TAFII55; TAF2F; TATA box binding protein (TBP)-associated factor, RNA polymerase II, F, 55kD; RNA polymerase ......
Chromosomal Location5q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF04658 TAFII55 protein conserved region
Function

Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively).

> Gene Ontology
 
Biological Process GO:0000296 spermine transport
GO:0001933 negative regulation of protein phosphorylation
GO:0006352 DNA-templated transcription, initiation
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006469 negative regulation of protein kinase activity
GO:0006473 protein acetylation
GO:0006475 internal protein amino acid acetylation
GO:0009755 hormone-mediated signaling pathway
GO:0015846 polyamine transport
GO:0016570 histone modification
GO:0016573 histone acetylation
GO:0018205 peptidyl-lysine modification
GO:0018393 internal peptidyl-lysine acetylation
GO:0018394 peptidyl-lysine acetylation
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0030522 intracellular receptor signaling pathway
GO:0031056 regulation of histone modification
GO:0031057 negative regulation of histone modification
GO:0033673 negative regulation of kinase activity
GO:0035065 regulation of histone acetylation
GO:0035067 negative regulation of histone acetylation
GO:0042326 negative regulation of phosphorylation
GO:0043401 steroid hormone mediated signaling pathway
GO:0043543 protein acylation
GO:0048545 response to steroid hormone
GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly
GO:0051348 negative regulation of transferase activity
GO:0065004 protein-DNA complex assembly
GO:0070897 DNA-templated transcriptional preinitiation complex assembly
GO:0071383 cellular response to steroid hormone stimulus
GO:0071396 cellular response to lipid
GO:0071407 cellular response to organic cyclic compound
GO:0071824 protein-DNA complex subunit organization
GO:1901983 regulation of protein acetylation
GO:1901984 negative regulation of protein acetylation
GO:1902275 regulation of chromatin organization
GO:1905268 negative regulation of chromatin organization
GO:2000756 regulation of peptidyl-lysine acetylation
GO:2000757 negative regulation of peptidyl-lysine acetylation
Molecular Function GO:0003713 transcription coactivator activity
GO:0008134 transcription factor binding
GO:0035035 histone acetyltransferase binding
GO:0035257 nuclear hormone receptor binding
GO:0042809 vitamin D receptor binding
GO:0046966 thyroid hormone receptor binding
GO:0051427 hormone receptor binding
Cellular Component GO:0000123 histone acetyltransferase complex
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0000428 DNA-directed RNA polymerase complex
GO:0005667 transcription factor complex
GO:0005669 transcription factor TFIID complex
GO:0008023 transcription elongation factor complex
GO:0008024 cyclin/CDK positive transcription elongation factor complex
GO:0016591 DNA-directed RNA polymerase II, holoenzyme
GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex
GO:0030880 RNA polymerase complex
GO:0031248 protein acetyltransferase complex
GO:0032806 carboxy-terminal domain protein kinase complex
GO:0033276 transcription factor TFTC complex
GO:0034708 methyltransferase complex
GO:0035097 histone methyltransferase complex
GO:0044665 MLL1/2 complex
GO:0044798 nuclear transcription factor complex
GO:0055029 nuclear DNA-directed RNA polymerase complex
GO:0061695 transferase complex, transferring phosphorus-containing groups
GO:0070461 SAGA-type complex
GO:0071339 MLL1 complex
GO:0090575 RNA polymerase II transcription factor complex
GO:1902493 acetyltransferase complex
GO:1902554 serine/threonine protein kinase complex
GO:1902911 protein kinase complex
> KEGG and Reactome Pathway
 
KEGG hsa03022 Basal transcription factors
Reactome R-HSA-1643685: Disease
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-162906: HIV Infection
R-HSA-162587: HIV Life Cycle
R-HSA-167161: HIV Transcription Initiation
R-HSA-5663205: Infectious disease
R-HSA-162599: Late Phase of HIV Life Cycle
R-HSA-167162: RNA Polymerase II HIV Promoter Escape
R-HSA-674695: RNA Polymerase II Pre-transcription Events
R-HSA-73776: RNA Polymerase II Promoter Escape
R-HSA-73857: RNA Polymerase II Transcription
R-HSA-75953: RNA Polymerase II Transcription Initiation
R-HSA-76042: RNA Polymerase II Transcription Initiation And Promoter Clearance
R-HSA-73779: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-5633007: Regulation of TP53 Activity
R-HSA-6804756: Regulation of TP53 Activity through Phosphorylation
R-HSA-167172: Transcription of the HIV genome
R-HSA-3700989: Transcriptional Regulation by TP53
Summary
SymbolTAF7
NameTAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
Aliases TAFII55; TAF2F; TATA box binding protein (TBP)-associated factor, RNA polymerase II, F, 55kD; RNA polymerase ......
Chromosomal Location5q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TAF7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolTAF7
NameTAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
Aliases TAFII55; TAF2F; TATA box binding protein (TBP)-associated factor, RNA polymerase II, F, 55kD; RNA polymerase ......
Chromosomal Location5q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TAF7 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.65 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolTAF7
NameTAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
Aliases TAFII55; TAF2F; TATA box binding protein (TBP)-associated factor, RNA polymerase II, F, 55kD; RNA polymerase ......
Chromosomal Location5q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TAF7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.3370.223
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.4560.859
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.2460.899
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3010.494
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1020.956
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.8180.745
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0390.933
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0750.97
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1770.935
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0640.974
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.2850.923
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0310.668
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TAF7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTAF7
NameTAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
Aliases TAFII55; TAF2F; TATA box binding protein (TBP)-associated factor, RNA polymerase II, F, 55kD; RNA polymerase ......
Chromosomal Location5q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TAF7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTAF7
NameTAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
Aliases TAFII55; TAF2F; TATA box binding protein (TBP)-associated factor, RNA polymerase II, F, 55kD; RNA polymerase ......
Chromosomal Location5q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TAF7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TAF7.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTAF7
NameTAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
Aliases TAFII55; TAF2F; TATA box binding protein (TBP)-associated factor, RNA polymerase II, F, 55kD; RNA polymerase ......
Chromosomal Location5q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TAF7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTAF7
NameTAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
Aliases TAFII55; TAF2F; TATA box binding protein (TBP)-associated factor, RNA polymerase II, F, 55kD; RNA polymerase ......
Chromosomal Location5q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TAF7 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTAF7
NameTAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
Aliases TAFII55; TAF2F; TATA box binding protein (TBP)-associated factor, RNA polymerase II, F, 55kD; RNA polymerase ......
Chromosomal Location5q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TAF7 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTAF7
NameTAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
Aliases TAFII55; TAF2F; TATA box binding protein (TBP)-associated factor, RNA polymerase II, F, 55kD; RNA polymerase ......
Chromosomal Location5q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TAF7 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.