Summary | |
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Symbol | TAF8 |
Name | TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa |
Aliases | FLJ32821; TAF(II)43; TBN; TATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 45/50kDa; ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Cytoplasm Note=Localized in the cytoplasm and transported from the cytoplasm to the nucleus in some cells, possibly depending on the functional or developmental state of the cell. |
Domain |
PF07524 Bromodomain associated PF10406 Transcription factor TFIID complex subunit 8 C-term |
Function |
Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity). |
Biological Process |
GO:0001701 in utero embryonic development GO:0001824 blastocyst development GO:0001832 blastocyst growth GO:0001833 inner cell mass cell proliferation GO:0009301 snRNA transcription GO:0016073 snRNA metabolic process GO:0032507 maintenance of protein location in cell GO:0034504 protein localization to nucleus GO:0042795 snRNA transcription from RNA polymerase II promoter GO:0045185 maintenance of protein location GO:0045444 fat cell differentiation GO:0045598 regulation of fat cell differentiation GO:0051235 maintenance of location GO:0051457 maintenance of protein location in nucleus GO:0051651 maintenance of location in cell GO:0072595 maintenance of protein localization in organelle GO:0098781 ncRNA transcription |
Molecular Function |
GO:0046982 protein heterodimerization activity |
Cellular Component |
GO:0000428 DNA-directed RNA polymerase complex GO:0005667 transcription factor complex GO:0005669 transcription factor TFIID complex GO:0016591 DNA-directed RNA polymerase II, holoenzyme GO:0030880 RNA polymerase complex GO:0044798 nuclear transcription factor complex GO:0055029 nuclear DNA-directed RNA polymerase complex GO:0061695 transferase complex, transferring phosphorus-containing groups GO:0090575 RNA polymerase II transcription factor complex |
KEGG |
hsa03022 Basal transcription factors |
Reactome |
R-HSA-74160: Gene Expression R-HSA-6807505: RNA polymerase II transcribes snRNA genes |
Summary | |
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Symbol | TAF8 |
Name | TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa |
Aliases | FLJ32821; TAF(II)43; TBN; TATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 45/50kDa; ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TAF8 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TAF8 |
Name | TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa |
Aliases | FLJ32821; TAF(II)43; TBN; TATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 45/50kDa; ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TAF8 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TAF8 |
Name | TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa |
Aliases | FLJ32821; TAF(II)43; TBN; TATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 45/50kDa; ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TAF8 in various data sets.
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Points in the above scatter plot represent the mutation difference of TAF8 in various data sets.
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Summary | |
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Symbol | TAF8 |
Name | TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa |
Aliases | FLJ32821; TAF(II)43; TBN; TATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 45/50kDa; ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TAF8. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TAF8 |
Name | TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa |
Aliases | FLJ32821; TAF(II)43; TBN; TATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 45/50kDa; ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TAF8. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TAF8. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TAF8 |
Name | TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa |
Aliases | FLJ32821; TAF(II)43; TBN; TATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 45/50kDa; ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TAF8. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TAF8 |
Name | TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa |
Aliases | FLJ32821; TAF(II)43; TBN; TATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 45/50kDa; ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TAF8 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TAF8 |
Name | TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa |
Aliases | FLJ32821; TAF(II)43; TBN; TATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 45/50kDa; ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TAF8 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TAF8 |
Name | TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa |
Aliases | FLJ32821; TAF(II)43; TBN; TATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 45/50kDa; ...... |
Chromosomal Location | 6p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TAF8 collected from DrugBank database. |
There is no record. |