Summary | |
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Symbol | TANC1 |
Name | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 |
Aliases | KIAA1728; ROLSB; TANC; TPR domain, ankyrin-repeat and coiled-coil-containing; tetratricopeptide repeat, anky ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell junction, synapse, postsynaptic cell membrane, postsynaptic density |
Domain |
PF12796 Ankyrin repeats (3 copies) |
Function |
May be a scaffold component in the postsynaptic density. |
Biological Process |
GO:0000768 syncytium formation by plasma membrane fusion GO:0006949 syncytium formation GO:0007520 myoblast fusion GO:0007611 learning or memory GO:0007612 learning GO:0007632 visual behavior GO:0008306 associative learning GO:0008542 visual learning GO:0009314 response to radiation GO:0009416 response to light stimulus GO:0014902 myotube differentiation GO:0042692 muscle cell differentiation GO:0043954 cellular component maintenance GO:0044708 single-organism behavior GO:0050890 cognition GO:0051146 striated muscle cell differentiation GO:0097061 dendritic spine organization GO:0097062 dendritic spine maintenance |
Molecular Function | - |
Cellular Component |
GO:0014069 postsynaptic density GO:0030424 axon GO:0030425 dendrite GO:0033267 axon part GO:0043025 neuronal cell body GO:0043679 axon terminus GO:0044297 cell body GO:0044306 neuron projection terminus GO:0045211 postsynaptic membrane GO:0060076 excitatory synapse GO:0097060 synaptic membrane GO:0098794 postsynapse GO:0099572 postsynaptic specialization |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | TANC1 |
Name | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 |
Aliases | KIAA1728; ROLSB; TANC; TPR domain, ankyrin-repeat and coiled-coil-containing; tetratricopeptide repeat, anky ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TANC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | TANC1 |
Name | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 |
Aliases | KIAA1728; ROLSB; TANC; TPR domain, ankyrin-repeat and coiled-coil-containing; tetratricopeptide repeat, anky ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TANC1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TANC1 |
Name | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 |
Aliases | KIAA1728; ROLSB; TANC; TPR domain, ankyrin-repeat and coiled-coil-containing; tetratricopeptide repeat, anky ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TANC1 in various data sets.
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Points in the above scatter plot represent the mutation difference of TANC1 in various data sets.
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Summary | |
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Symbol | TANC1 |
Name | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 |
Aliases | KIAA1728; ROLSB; TANC; TPR domain, ankyrin-repeat and coiled-coil-containing; tetratricopeptide repeat, anky ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TANC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TANC1 |
Name | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 |
Aliases | KIAA1728; ROLSB; TANC; TPR domain, ankyrin-repeat and coiled-coil-containing; tetratricopeptide repeat, anky ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TANC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TANC1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TANC1 |
Name | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 |
Aliases | KIAA1728; ROLSB; TANC; TPR domain, ankyrin-repeat and coiled-coil-containing; tetratricopeptide repeat, anky ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TANC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TANC1 |
Name | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 |
Aliases | KIAA1728; ROLSB; TANC; TPR domain, ankyrin-repeat and coiled-coil-containing; tetratricopeptide repeat, anky ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TANC1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TANC1 |
Name | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 |
Aliases | KIAA1728; ROLSB; TANC; TPR domain, ankyrin-repeat and coiled-coil-containing; tetratricopeptide repeat, anky ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TANC1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TANC1 |
Name | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 |
Aliases | KIAA1728; ROLSB; TANC; TPR domain, ankyrin-repeat and coiled-coil-containing; tetratricopeptide repeat, anky ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TANC1 collected from DrugBank database. |
There is no record. |