Browse TANC1

Summary
SymbolTANC1
Nametetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Aliases KIAA1728; ROLSB; TANC; TPR domain, ankyrin-repeat and coiled-coil-containing; tetratricopeptide repeat, anky ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell junction, synapse, postsynaptic cell membrane, postsynaptic density
Domain PF12796 Ankyrin repeats (3 copies)
Function

May be a scaffold component in the postsynaptic density.

> Gene Ontology
 
Biological Process GO:0000768 syncytium formation by plasma membrane fusion
GO:0006949 syncytium formation
GO:0007520 myoblast fusion
GO:0007611 learning or memory
GO:0007612 learning
GO:0007632 visual behavior
GO:0008306 associative learning
GO:0008542 visual learning
GO:0009314 response to radiation
GO:0009416 response to light stimulus
GO:0014902 myotube differentiation
GO:0042692 muscle cell differentiation
GO:0043954 cellular component maintenance
GO:0044708 single-organism behavior
GO:0050890 cognition
GO:0051146 striated muscle cell differentiation
GO:0097061 dendritic spine organization
GO:0097062 dendritic spine maintenance
Molecular Function -
Cellular Component GO:0014069 postsynaptic density
GO:0030424 axon
GO:0030425 dendrite
GO:0033267 axon part
GO:0043025 neuronal cell body
GO:0043679 axon terminus
GO:0044297 cell body
GO:0044306 neuron projection terminus
GO:0045211 postsynaptic membrane
GO:0060076 excitatory synapse
GO:0097060 synaptic membrane
GO:0098794 postsynapse
GO:0099572 postsynaptic specialization
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolTANC1
Nametetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Aliases KIAA1728; ROLSB; TANC; TPR domain, ankyrin-repeat and coiled-coil-containing; tetratricopeptide repeat, anky ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TANC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolTANC1
Nametetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Aliases KIAA1728; ROLSB; TANC; TPR domain, ankyrin-repeat and coiled-coil-containing; tetratricopeptide repeat, anky ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TANC1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTANC1
Nametetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Aliases KIAA1728; ROLSB; TANC; TPR domain, ankyrin-repeat and coiled-coil-containing; tetratricopeptide repeat, anky ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TANC1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1570.635
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1850.913
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.4180.699
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2270.512
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.220.931
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.7940.81
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2690.525
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2170.901
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3750.842
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2330.82
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.1450.392
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1720.0162
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TANC1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.82.712.10.0439
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.83.411.40.0746
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86016.7-16.70.429
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59200200.357
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolTANC1
Nametetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Aliases KIAA1728; ROLSB; TANC; TPR domain, ankyrin-repeat and coiled-coil-containing; tetratricopeptide repeat, anky ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TANC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTANC1
Nametetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Aliases KIAA1728; ROLSB; TANC; TPR domain, ankyrin-repeat and coiled-coil-containing; tetratricopeptide repeat, anky ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TANC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TANC1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTANC1
Nametetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Aliases KIAA1728; ROLSB; TANC; TPR domain, ankyrin-repeat and coiled-coil-containing; tetratricopeptide repeat, anky ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TANC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTANC1
Nametetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Aliases KIAA1728; ROLSB; TANC; TPR domain, ankyrin-repeat and coiled-coil-containing; tetratricopeptide repeat, anky ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TANC1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTANC1
Nametetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Aliases KIAA1728; ROLSB; TANC; TPR domain, ankyrin-repeat and coiled-coil-containing; tetratricopeptide repeat, anky ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TANC1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTANC1
Nametetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Aliases KIAA1728; ROLSB; TANC; TPR domain, ankyrin-repeat and coiled-coil-containing; tetratricopeptide repeat, anky ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TANC1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.