Summary | |
---|---|
Symbol | TAPBP |
Name | TAP binding protein (tapasin) |
Aliases | TAPA; NGS17; TPN; TPSN; NGS-17; TAP-associated protein; TAP-binding protein; Tapasin |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane Single-pass type I membrane protein |
Domain |
PF07654 Immunoglobulin C1-set domain |
Function |
Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). |
Biological Process |
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I GO:0002483 antigen processing and presentation of endogenous peptide antigen GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0019882 antigen processing and presentation GO:0019883 antigen processing and presentation of endogenous antigen GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0048002 antigen processing and presentation of peptide antigen GO:0048193 Golgi vesicle transport GO:0050822 peptide stabilization GO:0050823 peptide antigen stabilization GO:0061635 regulation of protein complex stability |
Molecular Function |
GO:0003823 antigen binding GO:0015399 primary active transmembrane transporter activity GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity GO:0015433 peptide antigen-transporting ATPase activity GO:0015440 peptide-transporting ATPase activity GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0016887 ATPase activity GO:0022804 active transmembrane transporter activity GO:0033218 amide binding GO:0042277 peptide binding GO:0042287 MHC protein binding GO:0042288 MHC class I protein binding GO:0042605 peptide antigen binding GO:0042623 ATPase activity, coupled GO:0042626 ATPase activity, coupled to transmembrane movement of substances GO:0043492 ATPase activity, coupled to movement of substances GO:0046977 TAP binding GO:0046978 TAP1 binding GO:0046979 TAP2 binding GO:0051082 unfolded protein binding |
Cellular Component |
GO:0030176 integral component of endoplasmic reticulum membrane GO:0031227 intrinsic component of endoplasmic reticulum membrane GO:0042824 MHC class I peptide loading complex GO:0042825 TAP complex GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane GO:0098552 side of membrane GO:0098553 lumenal side of endoplasmic reticulum membrane |
KEGG |
hsa04612 Antigen processing and presentation |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-983170: Antigen Presentation R-HSA-1236975: Antigen processing-Cross presentation R-HSA-983169: Class I MHC mediated antigen processing & presentation R-HSA-1236974: ER-Phagosome pathway R-HSA-168256: Immune System |
Summary | |
---|---|
Symbol | TAPBP |
Name | TAP binding protein (tapasin) |
Aliases | TAPA; NGS17; TPN; TPSN; NGS-17; TAP-associated protein; TAP-binding protein; Tapasin |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TAPBP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between TAPBP and anti-tumor immunity in human cancer.
|
Summary | |
---|---|
Symbol | TAPBP |
Name | TAP binding protein (tapasin) |
Aliases | TAPA; NGS17; TPN; TPSN; NGS-17; TAP-associated protein; TAP-binding protein; Tapasin |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of TAPBP in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | TAPBP |
Name | TAP binding protein (tapasin) |
Aliases | TAPA; NGS17; TPN; TPSN; NGS-17; TAP-associated protein; TAP-binding protein; Tapasin |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TAPBP in various data sets.
|
Points in the above scatter plot represent the mutation difference of TAPBP in various data sets.
|
Summary | |
---|---|
Symbol | TAPBP |
Name | TAP binding protein (tapasin) |
Aliases | TAPA; NGS17; TPN; TPSN; NGS-17; TAP-associated protein; TAP-binding protein; Tapasin |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TAPBP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TAPBP |
Name | TAP binding protein (tapasin) |
Aliases | TAPA; NGS17; TPN; TPSN; NGS-17; TAP-associated protein; TAP-binding protein; Tapasin |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TAPBP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TAPBP. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TAPBP |
Name | TAP binding protein (tapasin) |
Aliases | TAPA; NGS17; TPN; TPSN; NGS-17; TAP-associated protein; TAP-binding protein; Tapasin |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TAPBP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TAPBP |
Name | TAP binding protein (tapasin) |
Aliases | TAPA; NGS17; TPN; TPSN; NGS-17; TAP-associated protein; TAP-binding protein; Tapasin |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TAPBP expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TAPBP |
Name | TAP binding protein (tapasin) |
Aliases | TAPA; NGS17; TPN; TPSN; NGS-17; TAP-associated protein; TAP-binding protein; Tapasin |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TAPBP and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TAPBP |
Name | TAP binding protein (tapasin) |
Aliases | TAPA; NGS17; TPN; TPSN; NGS-17; TAP-associated protein; TAP-binding protein; Tapasin |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TAPBP collected from DrugBank database. |
There is no record. |