Browse TAPBP

Summary
SymbolTAPBP
NameTAP binding protein (tapasin)
Aliases TAPA; NGS17; TPN; TPSN; NGS-17; TAP-associated protein; TAP-binding protein; Tapasin
Chromosomal Location6p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Endoplasmic reticulum membrane Single-pass type I membrane protein
Domain PF07654 Immunoglobulin C1-set domain
Function

Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).

> Gene Ontology
 
Biological Process GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002483 antigen processing and presentation of endogenous peptide antigen
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
GO:0019882 antigen processing and presentation
GO:0019883 antigen processing and presentation of endogenous antigen
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0048002 antigen processing and presentation of peptide antigen
GO:0048193 Golgi vesicle transport
GO:0050822 peptide stabilization
GO:0050823 peptide antigen stabilization
GO:0061635 regulation of protein complex stability
Molecular Function GO:0003823 antigen binding
GO:0015399 primary active transmembrane transporter activity
GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity
GO:0015433 peptide antigen-transporting ATPase activity
GO:0015440 peptide-transporting ATPase activity
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0016887 ATPase activity
GO:0022804 active transmembrane transporter activity
GO:0033218 amide binding
GO:0042277 peptide binding
GO:0042287 MHC protein binding
GO:0042288 MHC class I protein binding
GO:0042605 peptide antigen binding
GO:0042623 ATPase activity, coupled
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
GO:0043492 ATPase activity, coupled to movement of substances
GO:0046977 TAP binding
GO:0046978 TAP1 binding
GO:0046979 TAP2 binding
GO:0051082 unfolded protein binding
Cellular Component GO:0030176 integral component of endoplasmic reticulum membrane
GO:0031227 intrinsic component of endoplasmic reticulum membrane
GO:0042824 MHC class I peptide loading complex
GO:0042825 TAP complex
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
GO:0098552 side of membrane
GO:0098553 lumenal side of endoplasmic reticulum membrane
> KEGG and Reactome Pathway
 
KEGG hsa04612 Antigen processing and presentation
Reactome R-HSA-1280218: Adaptive Immune System
R-HSA-983170: Antigen Presentation
R-HSA-1236975: Antigen processing-Cross presentation
R-HSA-983169: Class I MHC mediated antigen processing & presentation
R-HSA-1236974: ER-Phagosome pathway
R-HSA-168256: Immune System
Summary
SymbolTAPBP
NameTAP binding protein (tapasin)
Aliases TAPA; NGS17; TPN; TPSN; NGS-17; TAP-associated protein; TAP-binding protein; Tapasin
Chromosomal Location6p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TAPBP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between TAPBP and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
26381407MelanomaPromote immunityThis treatment combined with tapasin reconstitution and IFN-γ stimulation restored the highest level of HLA class I expression and its ability to elicit cytotoxic T cell responses.
16517708Head and Neck Squamous Cell CarcinomaPromote immunity (T cell function)First, lack of recognition of SCCHN cells by CTL is associated with marked down-regulation of the IFN-gamma-inducible APM components low-m.w. protein 2, TAP1, TAP2, and tapasin.
28783722MelanomaPromote immunity (T cell function); essential for immunotherapyOn the basis of our initial optimization of the 2CT-CRISPR assay, we expected that genes directly associated with MHC class I antigen processing and presentation would be enriched in our screens, and found that HLA-A, B2M, TAP1, TAP2, and TAPBP were among the most highly-enriched genes in our screen
28783722MelanomaPromote immunity (T cell function)Fifteen genes showed significant resistance to T-cell-mediated cytolysis with at least 1 sgRNA in these cells.
Summary
SymbolTAPBP
NameTAP binding protein (tapasin)
Aliases TAPA; NGS17; TPN; TPSN; NGS-17; TAP-associated protein; TAP-binding protein; Tapasin
Chromosomal Location6p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TAPBP in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 1.33 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 STARS Score: 5.36; FDR: 0.001 Resistant to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX STARS Score: 4.07; FDR: 0.021 Resistant to T cell-mediated killing
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolTAPBP
NameTAP binding protein (tapasin)
Aliases TAPA; NGS17; TPN; TPSN; NGS-17; TAP-associated protein; TAP-binding protein; Tapasin
Chromosomal Location6p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TAPBP in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2610.268
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1590.822
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3380.515
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.660.103
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.840.757
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4320.901
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3210.515
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.5460.773
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0011
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.7890.732
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.750.826
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0140.846
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TAPBP in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.14.170.339
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.15.160.373
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTAPBP
NameTAP binding protein (tapasin)
Aliases TAPA; NGS17; TPN; TPSN; NGS-17; TAP-associated protein; TAP-binding protein; Tapasin
Chromosomal Location6p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TAPBP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTAPBP
NameTAP binding protein (tapasin)
Aliases TAPA; NGS17; TPN; TPSN; NGS-17; TAP-associated protein; TAP-binding protein; Tapasin
Chromosomal Location6p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TAPBP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TAPBP.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTAPBP
NameTAP binding protein (tapasin)
Aliases TAPA; NGS17; TPN; TPSN; NGS-17; TAP-associated protein; TAP-binding protein; Tapasin
Chromosomal Location6p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TAPBP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTAPBP
NameTAP binding protein (tapasin)
Aliases TAPA; NGS17; TPN; TPSN; NGS-17; TAP-associated protein; TAP-binding protein; Tapasin
Chromosomal Location6p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TAPBP expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTAPBP
NameTAP binding protein (tapasin)
Aliases TAPA; NGS17; TPN; TPSN; NGS-17; TAP-associated protein; TAP-binding protein; Tapasin
Chromosomal Location6p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TAPBP and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTAPBP
NameTAP binding protein (tapasin)
Aliases TAPA; NGS17; TPN; TPSN; NGS-17; TAP-associated protein; TAP-binding protein; Tapasin
Chromosomal Location6p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TAPBP collected from DrugBank database.
> Drugs from DrugBank database
 

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