Summary | |
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Symbol | TAPBPL |
Name | TAP binding protein-like |
Aliases | TAPBP-R; FLJ10143; TAPBPR; TAP binding protein related; TAP-binding protein-like; TAP-binding protein-relate ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein Endoplasmic reticulum membrane Single-pass type I membrane protein Microsome membrane Single-pass type I membrane protein Golgi apparatus membrane Single-pass type I membrane protein Note=Mainly found in endoplasmic reticulum but a minority is found on the cell surface (PubMed:11920573). |
Domain |
PF07654 Immunoglobulin C1-set domain PF07686 Immunoglobulin V-set domain |
Function |
Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression. |
Biological Process |
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I GO:0002577 regulation of antigen processing and presentation GO:0002578 negative regulation of antigen processing and presentation GO:0002583 regulation of antigen processing and presentation of peptide antigen GO:0002584 negative regulation of antigen processing and presentation of peptide antigen GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I GO:0002590 negative regulation of antigen processing and presentation of peptide antigen via MHC class I GO:0002683 negative regulation of immune system process GO:0019882 antigen processing and presentation GO:0048002 antigen processing and presentation of peptide antigen |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | TAPBPL |
Name | TAP binding protein-like |
Aliases | TAPBP-R; FLJ10143; TAPBPR; TAP binding protein related; TAP-binding protein-like; TAP-binding protein-relate ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TAPBPL and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TAPBPL |
Name | TAP binding protein-like |
Aliases | TAPBP-R; FLJ10143; TAPBPR; TAP binding protein related; TAP-binding protein-like; TAP-binding protein-relate ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TAPBPL in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TAPBPL |
Name | TAP binding protein-like |
Aliases | TAPBP-R; FLJ10143; TAPBPR; TAP binding protein related; TAP-binding protein-like; TAP-binding protein-relate ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TAPBPL in various data sets.
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Points in the above scatter plot represent the mutation difference of TAPBPL in various data sets.
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Summary | |
---|---|
Symbol | TAPBPL |
Name | TAP binding protein-like |
Aliases | TAPBP-R; FLJ10143; TAPBPR; TAP binding protein related; TAP-binding protein-like; TAP-binding protein-relate ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TAPBPL. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TAPBPL |
Name | TAP binding protein-like |
Aliases | TAPBP-R; FLJ10143; TAPBPR; TAP binding protein related; TAP-binding protein-like; TAP-binding protein-relate ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TAPBPL. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TAPBPL. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TAPBPL |
Name | TAP binding protein-like |
Aliases | TAPBP-R; FLJ10143; TAPBPR; TAP binding protein related; TAP-binding protein-like; TAP-binding protein-relate ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TAPBPL. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TAPBPL |
Name | TAP binding protein-like |
Aliases | TAPBP-R; FLJ10143; TAPBPR; TAP binding protein related; TAP-binding protein-like; TAP-binding protein-relate ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TAPBPL expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TAPBPL |
Name | TAP binding protein-like |
Aliases | TAPBP-R; FLJ10143; TAPBPR; TAP binding protein related; TAP-binding protein-like; TAP-binding protein-relate ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TAPBPL and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TAPBPL |
Name | TAP binding protein-like |
Aliases | TAPBP-R; FLJ10143; TAPBPR; TAP binding protein related; TAP-binding protein-like; TAP-binding protein-relate ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TAPBPL collected from DrugBank database. |
There is no record. |