Summary | |
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Symbol | TAS2R39 |
Name | taste receptor, type 2, member 39 |
Aliases | T2R39; T2R57; taste receptor type 2 member 57; Taste receptor type 2 member 39 |
Chromosomal Location | 7q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Domain |
PF05296 Taste receptor protein (TAS2R) |
Function |
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). |
Biological Process |
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste GO:0050907 detection of chemical stimulus involved in sensory perception GO:0050909 sensory perception of taste GO:0050912 detection of chemical stimulus involved in sensory perception of taste GO:0050913 sensory perception of bitter taste |
Molecular Function |
GO:0008527 taste receptor activity GO:0033038 bitter taste receptor activity |
Cellular Component | - |
KEGG |
hsa04742 Taste transduction |
Reactome |
R-HSA-420499: Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-418594: G alpha (i) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
---|---|
Symbol | TAS2R39 |
Name | taste receptor, type 2, member 39 |
Aliases | T2R39; T2R57; taste receptor type 2 member 57; Taste receptor type 2 member 39 |
Chromosomal Location | 7q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TAS2R39 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TAS2R39 |
Name | taste receptor, type 2, member 39 |
Aliases | T2R39; T2R57; taste receptor type 2 member 57; Taste receptor type 2 member 39 |
Chromosomal Location | 7q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TAS2R39 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | TAS2R39 |
Name | taste receptor, type 2, member 39 |
Aliases | T2R39; T2R57; taste receptor type 2 member 57; Taste receptor type 2 member 39 |
Chromosomal Location | 7q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TAS2R39 in various data sets.
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Points in the above scatter plot represent the mutation difference of TAS2R39 in various data sets.
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Summary | |
---|---|
Symbol | TAS2R39 |
Name | taste receptor, type 2, member 39 |
Aliases | T2R39; T2R57; taste receptor type 2 member 57; Taste receptor type 2 member 39 |
Chromosomal Location | 7q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TAS2R39. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TAS2R39 |
Name | taste receptor, type 2, member 39 |
Aliases | T2R39; T2R57; taste receptor type 2 member 57; Taste receptor type 2 member 39 |
Chromosomal Location | 7q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TAS2R39. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TAS2R39. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TAS2R39 |
Name | taste receptor, type 2, member 39 |
Aliases | T2R39; T2R57; taste receptor type 2 member 57; Taste receptor type 2 member 39 |
Chromosomal Location | 7q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TAS2R39. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TAS2R39 |
Name | taste receptor, type 2, member 39 |
Aliases | T2R39; T2R57; taste receptor type 2 member 57; Taste receptor type 2 member 39 |
Chromosomal Location | 7q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TAS2R39 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TAS2R39 |
Name | taste receptor, type 2, member 39 |
Aliases | T2R39; T2R57; taste receptor type 2 member 57; Taste receptor type 2 member 39 |
Chromosomal Location | 7q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TAS2R39 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TAS2R39 |
Name | taste receptor, type 2, member 39 |
Aliases | T2R39; T2R57; taste receptor type 2 member 57; Taste receptor type 2 member 39 |
Chromosomal Location | 7q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TAS2R39 collected from DrugBank database. |
There is no record. |