Summary | |
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Symbol | TAS2R43 |
Name | taste receptor, type 2, member 43 |
Aliases | T2R52; T2R43; taste receptor type 2 member 52; Taste receptor type 2 member 43 |
Chromosomal Location | 12p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Multi-pass membrane protein Cell projection, cilium membrane Note=In airway epithelial cells, localizes to motile cilia. |
Domain |
PF05296 Taste receptor protein (TAS2R) |
Function |
Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by the sulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. May act as chemosensory receptors in airway epithelial cells to detect and eliminate potential noxious agents from the airways (By similarity). |
Biological Process |
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste GO:0050907 detection of chemical stimulus involved in sensory perception GO:0050909 sensory perception of taste GO:0050912 detection of chemical stimulus involved in sensory perception of taste GO:0050913 sensory perception of bitter taste |
Molecular Function |
GO:0008527 taste receptor activity GO:0033038 bitter taste receptor activity |
Cellular Component |
GO:0005929 cilium GO:0031253 cell projection membrane GO:0031514 motile cilium GO:0044441 ciliary part GO:0060170 ciliary membrane |
KEGG |
hsa04742 Taste transduction |
Reactome |
R-HSA-420499: Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-418594: G alpha (i) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | TAS2R43 |
Name | taste receptor, type 2, member 43 |
Aliases | T2R52; T2R43; taste receptor type 2 member 52; Taste receptor type 2 member 43 |
Chromosomal Location | 12p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TAS2R43 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TAS2R43 |
Name | taste receptor, type 2, member 43 |
Aliases | T2R52; T2R43; taste receptor type 2 member 52; Taste receptor type 2 member 43 |
Chromosomal Location | 12p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TAS2R43 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TAS2R43 |
Name | taste receptor, type 2, member 43 |
Aliases | T2R52; T2R43; taste receptor type 2 member 52; Taste receptor type 2 member 43 |
Chromosomal Location | 12p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TAS2R43 in various data sets.
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Points in the above scatter plot represent the mutation difference of TAS2R43 in various data sets.
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Summary | |
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Symbol | TAS2R43 |
Name | taste receptor, type 2, member 43 |
Aliases | T2R52; T2R43; taste receptor type 2 member 52; Taste receptor type 2 member 43 |
Chromosomal Location | 12p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TAS2R43. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TAS2R43 |
Name | taste receptor, type 2, member 43 |
Aliases | T2R52; T2R43; taste receptor type 2 member 52; Taste receptor type 2 member 43 |
Chromosomal Location | 12p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TAS2R43. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TAS2R43. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TAS2R43 |
Name | taste receptor, type 2, member 43 |
Aliases | T2R52; T2R43; taste receptor type 2 member 52; Taste receptor type 2 member 43 |
Chromosomal Location | 12p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TAS2R43. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TAS2R43 |
Name | taste receptor, type 2, member 43 |
Aliases | T2R52; T2R43; taste receptor type 2 member 52; Taste receptor type 2 member 43 |
Chromosomal Location | 12p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TAS2R43 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TAS2R43 |
Name | taste receptor, type 2, member 43 |
Aliases | T2R52; T2R43; taste receptor type 2 member 52; Taste receptor type 2 member 43 |
Chromosomal Location | 12p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TAS2R43 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TAS2R43 |
Name | taste receptor, type 2, member 43 |
Aliases | T2R52; T2R43; taste receptor type 2 member 52; Taste receptor type 2 member 43 |
Chromosomal Location | 12p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TAS2R43 collected from DrugBank database. |
There is no record. |