Summary | |
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Symbol | TBC1D22A |
Name | TBC1 domain family, member 22A |
Aliases | C22orf4; chromosome 22 open reading frame 4; HSC79E021; putative GTPase activator; TBC1 domain family member ...... |
Chromosomal Location | 22q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00566 Rab-GTPase-TBC domain |
Function |
May act as a GTPase-activating protein for Rab family protein(s). |
Biological Process |
GO:0006906 vesicle fusion GO:0016050 vesicle organization GO:0031338 regulation of vesicle fusion GO:0044801 single-organism membrane fusion GO:0048284 organelle fusion GO:0060627 regulation of vesicle-mediated transport GO:0061025 membrane fusion GO:0090174 organelle membrane fusion GO:0090630 activation of GTPase activity |
Molecular Function |
GO:0005096 GTPase activator activity GO:0008047 enzyme activator activity GO:0017016 Ras GTPase binding GO:0017137 Rab GTPase binding GO:0030695 GTPase regulator activity GO:0031267 small GTPase binding GO:0051020 GTPase binding GO:0060589 nucleoside-triphosphatase regulator activity GO:0071889 14-3-3 protein binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | TBC1D22A |
Name | TBC1 domain family, member 22A |
Aliases | C22orf4; chromosome 22 open reading frame 4; HSC79E021; putative GTPase activator; TBC1 domain family member ...... |
Chromosomal Location | 22q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TBC1D22A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | TBC1D22A |
Name | TBC1 domain family, member 22A |
Aliases | C22orf4; chromosome 22 open reading frame 4; HSC79E021; putative GTPase activator; TBC1 domain family member ...... |
Chromosomal Location | 22q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TBC1D22A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TBC1D22A |
Name | TBC1 domain family, member 22A |
Aliases | C22orf4; chromosome 22 open reading frame 4; HSC79E021; putative GTPase activator; TBC1 domain family member ...... |
Chromosomal Location | 22q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TBC1D22A in various data sets.
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Points in the above scatter plot represent the mutation difference of TBC1D22A in various data sets.
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Summary | |
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Symbol | TBC1D22A |
Name | TBC1 domain family, member 22A |
Aliases | C22orf4; chromosome 22 open reading frame 4; HSC79E021; putative GTPase activator; TBC1 domain family member ...... |
Chromosomal Location | 22q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TBC1D22A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TBC1D22A |
Name | TBC1 domain family, member 22A |
Aliases | C22orf4; chromosome 22 open reading frame 4; HSC79E021; putative GTPase activator; TBC1 domain family member ...... |
Chromosomal Location | 22q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TBC1D22A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TBC1D22A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TBC1D22A |
Name | TBC1 domain family, member 22A |
Aliases | C22orf4; chromosome 22 open reading frame 4; HSC79E021; putative GTPase activator; TBC1 domain family member ...... |
Chromosomal Location | 22q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TBC1D22A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TBC1D22A |
Name | TBC1 domain family, member 22A |
Aliases | C22orf4; chromosome 22 open reading frame 4; HSC79E021; putative GTPase activator; TBC1 domain family member ...... |
Chromosomal Location | 22q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TBC1D22A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TBC1D22A |
Name | TBC1 domain family, member 22A |
Aliases | C22orf4; chromosome 22 open reading frame 4; HSC79E021; putative GTPase activator; TBC1 domain family member ...... |
Chromosomal Location | 22q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TBC1D22A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TBC1D22A |
Name | TBC1 domain family, member 22A |
Aliases | C22orf4; chromosome 22 open reading frame 4; HSC79E021; putative GTPase activator; TBC1 domain family member ...... |
Chromosomal Location | 22q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TBC1D22A collected from DrugBank database. |
There is no record. |