Summary | |
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Symbol | TBX15 |
Name | T-box 15 |
Aliases | TBX14; T-box 14; T-box protein 14; T-box protein 15; T-box transcription factor TBX14; T-box transcription f ...... |
Chromosomal Location | 1p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF00907 T-box |
Function |
Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes (By similarity). |
Biological Process |
GO:0001501 skeletal system development GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048701 embryonic cranial skeleton morphogenesis GO:0048704 embryonic skeletal system morphogenesis GO:0048705 skeletal system morphogenesis GO:0048706 embryonic skeletal system development GO:1904888 cranial skeletal system development |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001104 RNA polymerase II transcription cofactor activity GO:0001106 RNA polymerase II transcription corepressor activity GO:0001159 core promoter proximal region DNA binding GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003714 transcription corepressor activity GO:0046982 protein heterodimerization activity |
Cellular Component |
GO:0017053 transcriptional repressor complex GO:0070722 Tle3-Aes complex GO:0090568 nuclear transcriptional repressor complex GO:0090571 RNA polymerase II transcription repressor complex |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | TBX15 |
Name | T-box 15 |
Aliases | TBX14; T-box 14; T-box protein 14; T-box protein 15; T-box transcription factor TBX14; T-box transcription f ...... |
Chromosomal Location | 1p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TBX15 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TBX15 |
Name | T-box 15 |
Aliases | TBX14; T-box 14; T-box protein 14; T-box protein 15; T-box transcription factor TBX14; T-box transcription f ...... |
Chromosomal Location | 1p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TBX15 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TBX15 |
Name | T-box 15 |
Aliases | TBX14; T-box 14; T-box protein 14; T-box protein 15; T-box transcription factor TBX14; T-box transcription f ...... |
Chromosomal Location | 1p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TBX15 in various data sets.
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Points in the above scatter plot represent the mutation difference of TBX15 in various data sets.
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Summary | |
---|---|
Symbol | TBX15 |
Name | T-box 15 |
Aliases | TBX14; T-box 14; T-box protein 14; T-box protein 15; T-box transcription factor TBX14; T-box transcription f ...... |
Chromosomal Location | 1p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TBX15. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TBX15 |
Name | T-box 15 |
Aliases | TBX14; T-box 14; T-box protein 14; T-box protein 15; T-box transcription factor TBX14; T-box transcription f ...... |
Chromosomal Location | 1p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TBX15. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TBX15. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TBX15 |
Name | T-box 15 |
Aliases | TBX14; T-box 14; T-box protein 14; T-box protein 15; T-box transcription factor TBX14; T-box transcription f ...... |
Chromosomal Location | 1p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TBX15. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TBX15 |
Name | T-box 15 |
Aliases | TBX14; T-box 14; T-box protein 14; T-box protein 15; T-box transcription factor TBX14; T-box transcription f ...... |
Chromosomal Location | 1p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TBX15 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TBX15 |
Name | T-box 15 |
Aliases | TBX14; T-box 14; T-box protein 14; T-box protein 15; T-box transcription factor TBX14; T-box transcription f ...... |
Chromosomal Location | 1p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TBX15 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TBX15 |
Name | T-box 15 |
Aliases | TBX14; T-box 14; T-box protein 14; T-box protein 15; T-box transcription factor TBX14; T-box transcription f ...... |
Chromosomal Location | 1p11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TBX15 collected from DrugBank database. |
There is no record. |