Browse TBX15

Summary
SymbolTBX15
NameT-box 15
Aliases TBX14; T-box 14; T-box protein 14; T-box protein 15; T-box transcription factor TBX14; T-box transcription f ......
Chromosomal Location1p11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF00907 T-box
Function

Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes (By similarity).

> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0048562 embryonic organ morphogenesis
GO:0048568 embryonic organ development
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:1904888 cranial skeletal system development
Molecular Function GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0001106 RNA polymerase II transcription corepressor activity
GO:0001159 core promoter proximal region DNA binding
GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003714 transcription corepressor activity
GO:0046982 protein heterodimerization activity
Cellular Component GO:0017053 transcriptional repressor complex
GO:0070722 Tle3-Aes complex
GO:0090568 nuclear transcriptional repressor complex
GO:0090571 RNA polymerase II transcription repressor complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolTBX15
NameT-box 15
Aliases TBX14; T-box 14; T-box protein 14; T-box protein 15; T-box transcription factor TBX14; T-box transcription f ......
Chromosomal Location1p11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TBX15 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolTBX15
NameT-box 15
Aliases TBX14; T-box 14; T-box protein 14; T-box protein 15; T-box transcription factor TBX14; T-box transcription f ......
Chromosomal Location1p11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TBX15 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTBX15
NameT-box 15
Aliases TBX14; T-box 14; T-box protein 14; T-box protein 15; T-box transcription factor TBX14; T-box transcription f ......
Chromosomal Location1p11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TBX15 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.7340.0488
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.320.0576
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.3090.612
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2170.643
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.6790.546
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.3540.356
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0390.955
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.4330.687
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.5590.601
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1410.836
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.1270.176
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.5040.0377
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TBX15 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.75.5-1.81
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.75.1-1.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.511.8-2.31
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.718.2-10.50.576
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTBX15
NameT-box 15
Aliases TBX14; T-box 14; T-box protein 14; T-box protein 15; T-box transcription factor TBX14; T-box transcription f ......
Chromosomal Location1p11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TBX15. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTBX15
NameT-box 15
Aliases TBX14; T-box 14; T-box protein 14; T-box protein 15; T-box transcription factor TBX14; T-box transcription f ......
Chromosomal Location1p11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TBX15. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TBX15.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTBX15
NameT-box 15
Aliases TBX14; T-box 14; T-box protein 14; T-box protein 15; T-box transcription factor TBX14; T-box transcription f ......
Chromosomal Location1p11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TBX15. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTBX15
NameT-box 15
Aliases TBX14; T-box 14; T-box protein 14; T-box protein 15; T-box transcription factor TBX14; T-box transcription f ......
Chromosomal Location1p11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TBX15 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTBX15
NameT-box 15
Aliases TBX14; T-box 14; T-box protein 14; T-box protein 15; T-box transcription factor TBX14; T-box transcription f ......
Chromosomal Location1p11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TBX15 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTBX15
NameT-box 15
Aliases TBX14; T-box 14; T-box protein 14; T-box protein 15; T-box transcription factor TBX14; T-box transcription f ......
Chromosomal Location1p11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TBX15 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.