TISIDB

Summary
Symbol	TBXAS1
Name	thromboxane A synthase 1 (platelet)
Aliases	CYP5; CYP5A1; TXS; TXAS; cytochrome P450, family 5, subfamily A, polypeptide 1; thromboxane A synthase 1 (pl ......
Chromosomal Location	7q34-q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Endoplasmic reticulum membrane Multi-pass membrane protein
Domain	PF00067 Cytochrome P450
Function	-

> Gene Ontology [ TOP ]
Biological Process	GO:0001516 prostaglandin biosynthetic process GO:0001676 long-chain fatty acid metabolic process GO:0006631 fatty acid metabolic process GO:0006633 fatty acid biosynthetic process GO:0006636 unsaturated fatty acid biosynthetic process GO:0006690 icosanoid metabolic process GO:0006692 prostanoid metabolic process GO:0006693 prostaglandin metabolic process GO:0016053 organic acid biosynthetic process GO:0019369 arachidonic acid metabolic process GO:0019371 cyclooxygenase pathway GO:0033559 unsaturated fatty acid metabolic process GO:0044283 small molecule biosynthetic process GO:0046394 carboxylic acid biosynthetic process GO:0046456 icosanoid biosynthetic process GO:0046457 prostanoid biosynthetic process GO:0072330 monocarboxylic acid biosynthetic process
Molecular Function	GO:0004497 monooxygenase activity GO:0004796 thromboxane-A synthase activity GO:0005506 iron ion binding GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016853 isomerase activity GO:0016860 intramolecular oxidoreductase activity GO:0020037 heme binding GO:0036134 12-hydroxyheptadecatrienoic acid synthase activity GO:0046906 tetrapyrrole binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04611 Platelet activation hsa00590 Arachidonic acid metabolism hsa01100 Metabolic pathways
Reactome	R-HSA-2142753: Arachidonic acid metabolism R-HSA-211859: Biological oxidations R-HSA-211897: Cytochrome P450 - arranged by substrate type R-HSA-211979: Eicosanoids R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-211945: Phase 1 - Functionalization of compounds R-HSA-2162123: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Summary
Symbol	TBXAS1
Name	thromboxane A synthase 1 (platelet)
Aliases	CYP5; CYP5A1; TXS; TXAS; cytochrome P450, family 5, subfamily A, polypeptide 1; thromboxane A synthase 1 (pl ......
Chromosomal Location	7q34-q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between TBXAS1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	TBXAS1
Name	thromboxane A synthase 1 (platelet)
Aliases	CYP5; CYP5A1; TXS; TXAS; cytochrome P450, family 5, subfamily A, polypeptide 1; thromboxane A synthase 1 (pl ......
Chromosomal Location	7q34-q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of TBXAS1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	Second most enriched score: 0.5	Sensitive to T cell-mediated killing
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	TBXAS1
Name	thromboxane A synthase 1 (platelet)
Aliases	CYP5; CYP5A1; TXS; TXAS; cytochrome P450, family 5, subfamily A, polypeptide 1; thromboxane A synthase 1 (pl ......
Chromosomal Location	7q34-q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of TBXAS1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.315	0.458
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.404	0.806
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.257	0.847
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.274	0.529
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.863	0.634
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.468	0.834
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.227	0.597
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.359	0.775
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.171	0.909
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.853	0.581
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.01	0.678
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.359	0.02

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of TBXAS1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	1.4	-1.4	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	1.7	-1.7	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	0	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	0	12.5	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	0	11.1	0.36
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	0	25	0.364
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	5.3	0	5.3	0.507
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	9.1	0	9.1	0.519
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	TBXAS1
Name	thromboxane A synthase 1 (platelet)
Aliases	CYP5; CYP5A1; TXS; TXAS; cytochrome P450, family 5, subfamily A, polypeptide 1; thromboxane A synthase 1 (pl ......
Chromosomal Location	7q34-q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TBXAS1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	TBXAS1
Name	thromboxane A synthase 1 (platelet)
Aliases	CYP5; CYP5A1; TXS; TXAS; cytochrome P450, family 5, subfamily A, polypeptide 1; thromboxane A synthase 1 (pl ......
Chromosomal Location	7q34-q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TBXAS1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TBXAS1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	TBXAS1
Name	thromboxane A synthase 1 (platelet)
Aliases	CYP5; CYP5A1; TXS; TXAS; cytochrome P450, family 5, subfamily A, polypeptide 1; thromboxane A synthase 1 (pl ......
Chromosomal Location	7q34-q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TBXAS1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	TBXAS1
Name	thromboxane A synthase 1 (platelet)
Aliases	CYP5; CYP5A1; TXS; TXAS; cytochrome P450, family 5, subfamily A, polypeptide 1; thromboxane A synthase 1 (pl ......
Chromosomal Location	7q34-q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of TBXAS1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	TBXAS1
Name	thromboxane A synthase 1 (platelet)
Aliases	CYP5; CYP5A1; TXS; TXAS; cytochrome P450, family 5, subfamily A, polypeptide 1; thromboxane A synthase 1 (pl ......
Chromosomal Location	7q34-q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between TBXAS1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	TBXAS1
Name	thromboxane A synthase 1 (platelet)
Aliases	CYP5; CYP5A1; TXS; TXAS; cytochrome P450, family 5, subfamily A, polypeptide 1; thromboxane A synthase 1 (pl ......
Chromosomal Location	7q34-q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting TBXAS1 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting TBXAS1.

ID	Name	Drug Type	Targets	#Targets
DB00795	Sulfasalazine	Small Molecule	ACAT1, ALOX5, CHUK, IKBKB, PLA2G1B, PPARG, PTGS1, PTGS2, SLC7A11, ......	10
DB01207	Ridogrel	Small Molecule	TBXA2R, TBXAS1	2
DB03052	Dazoxiben	Small Molecule	TBXAS1	1
DB05505	NM-702	Small Molecule	TBXAS1	1

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