Summary | |
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Symbol | TCEAL7 |
Name | transcription elongation factor A (SII)-like 7 |
Aliases | MGC23947; WEX5; MPMGp800C04260Q003; TCEA-like protein 7; transcription elongation factor S-II protein-like 7 ...... |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF04538 Brain expressed X-linked like family |
Function |
Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines. |
Biological Process |
GO:0032088 negative regulation of NF-kappaB transcription factor activity GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0051090 regulation of sequence-specific DNA binding transcription factor activity |
Molecular Function |
GO:0050699 WW domain binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | TCEAL7 |
Name | transcription elongation factor A (SII)-like 7 |
Aliases | MGC23947; WEX5; MPMGp800C04260Q003; TCEA-like protein 7; transcription elongation factor S-II protein-like 7 ...... |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TCEAL7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TCEAL7 |
Name | transcription elongation factor A (SII)-like 7 |
Aliases | MGC23947; WEX5; MPMGp800C04260Q003; TCEA-like protein 7; transcription elongation factor S-II protein-like 7 ...... |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TCEAL7 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | TCEAL7 |
Name | transcription elongation factor A (SII)-like 7 |
Aliases | MGC23947; WEX5; MPMGp800C04260Q003; TCEA-like protein 7; transcription elongation factor S-II protein-like 7 ...... |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TCEAL7 in various data sets.
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Points in the above scatter plot represent the mutation difference of TCEAL7 in various data sets.
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Summary | |
---|---|
Symbol | TCEAL7 |
Name | transcription elongation factor A (SII)-like 7 |
Aliases | MGC23947; WEX5; MPMGp800C04260Q003; TCEA-like protein 7; transcription elongation factor S-II protein-like 7 ...... |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TCEAL7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TCEAL7 |
Name | transcription elongation factor A (SII)-like 7 |
Aliases | MGC23947; WEX5; MPMGp800C04260Q003; TCEA-like protein 7; transcription elongation factor S-II protein-like 7 ...... |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TCEAL7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TCEAL7. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TCEAL7 |
Name | transcription elongation factor A (SII)-like 7 |
Aliases | MGC23947; WEX5; MPMGp800C04260Q003; TCEA-like protein 7; transcription elongation factor S-II protein-like 7 ...... |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TCEAL7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TCEAL7 |
Name | transcription elongation factor A (SII)-like 7 |
Aliases | MGC23947; WEX5; MPMGp800C04260Q003; TCEA-like protein 7; transcription elongation factor S-II protein-like 7 ...... |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TCEAL7 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TCEAL7 |
Name | transcription elongation factor A (SII)-like 7 |
Aliases | MGC23947; WEX5; MPMGp800C04260Q003; TCEA-like protein 7; transcription elongation factor S-II protein-like 7 ...... |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TCEAL7 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TCEAL7 |
Name | transcription elongation factor A (SII)-like 7 |
Aliases | MGC23947; WEX5; MPMGp800C04260Q003; TCEA-like protein 7; transcription elongation factor S-II protein-like 7 ...... |
Chromosomal Location | Xq22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TCEAL7 collected from DrugBank database. |
There is no record. |