Summary | |
---|---|
Symbol | TCL1A |
Name | T-cell leukemia/lymphoma 1A |
Aliases | TCL1; T-cell lymphoma-1; oncogene TCL-1; oncogene TCL1; protein p14 TCL1; T-cell leukemia/lymphoma protein 1 ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus Microsome Endoplasmic reticulum Note=Microsomal fraction. |
Domain |
PF01840 TCL1/MTCP1 family |
Function |
Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. |
Biological Process | - |
Molecular Function | - |
Cellular Component | - |
KEGG |
hsa04151 PI3K-Akt signaling pathway |
Reactome | - |
Summary | |
---|---|
Symbol | TCL1A |
Name | T-cell leukemia/lymphoma 1A |
Aliases | TCL1; T-cell lymphoma-1; oncogene TCL-1; oncogene TCL1; protein p14 TCL1; T-cell leukemia/lymphoma protein 1 ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TCL1A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between TCL1A and anti-tumor immunity in human cancer.
|
Summary | |
---|---|
Symbol | TCL1A |
Name | T-cell leukemia/lymphoma 1A |
Aliases | TCL1; T-cell lymphoma-1; oncogene TCL-1; oncogene TCL1; protein p14 TCL1; T-cell leukemia/lymphoma protein 1 ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of TCL1A in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | TCL1A |
Name | T-cell leukemia/lymphoma 1A |
Aliases | TCL1; T-cell lymphoma-1; oncogene TCL-1; oncogene TCL1; protein p14 TCL1; T-cell leukemia/lymphoma protein 1 ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TCL1A in various data sets.
|
Points in the above scatter plot represent the mutation difference of TCL1A in various data sets.
|
Summary | |
---|---|
Symbol | TCL1A |
Name | T-cell leukemia/lymphoma 1A |
Aliases | TCL1; T-cell lymphoma-1; oncogene TCL-1; oncogene TCL1; protein p14 TCL1; T-cell leukemia/lymphoma protein 1 ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TCL1A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TCL1A |
Name | T-cell leukemia/lymphoma 1A |
Aliases | TCL1; T-cell lymphoma-1; oncogene TCL-1; oncogene TCL1; protein p14 TCL1; T-cell leukemia/lymphoma protein 1 ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TCL1A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TCL1A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TCL1A |
Name | T-cell leukemia/lymphoma 1A |
Aliases | TCL1; T-cell lymphoma-1; oncogene TCL-1; oncogene TCL1; protein p14 TCL1; T-cell leukemia/lymphoma protein 1 ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TCL1A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TCL1A |
Name | T-cell leukemia/lymphoma 1A |
Aliases | TCL1; T-cell lymphoma-1; oncogene TCL-1; oncogene TCL1; protein p14 TCL1; T-cell leukemia/lymphoma protein 1 ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TCL1A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TCL1A |
Name | T-cell leukemia/lymphoma 1A |
Aliases | TCL1; T-cell lymphoma-1; oncogene TCL-1; oncogene TCL1; protein p14 TCL1; T-cell leukemia/lymphoma protein 1 ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TCL1A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TCL1A |
Name | T-cell leukemia/lymphoma 1A |
Aliases | TCL1; T-cell lymphoma-1; oncogene TCL-1; oncogene TCL1; protein p14 TCL1; T-cell leukemia/lymphoma protein 1 ...... |
Chromosomal Location | 14q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TCL1A collected from DrugBank database. |
There is no record. |