Summary | |
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Symbol | TCP11 |
Name | t-complex 11, testis-specific |
Aliases | FPPR; fertilization-promoting peptide receptor; t-complex 11 (a murine tcp homolog); t-complex 11 homolog (m ...... |
Chromosomal Location | 6p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass membrane protein Cell projection, cilium, flagellum Cytoplasmic vesicle, secretory vesicle, acrosome Note=Localizes on the acrosomal cap region of acrosome-intact, but not acrosome-reacted sperm. Colocalizes with MROH2B and PRKACA on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm. |
Domain |
PF05794 T-complex protein 11 |
Function |
Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway. |
Biological Process |
GO:0007283 spermatogenesis GO:0048232 male gamete generation |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | TCP11 |
Name | t-complex 11, testis-specific |
Aliases | FPPR; fertilization-promoting peptide receptor; t-complex 11 (a murine tcp homolog); t-complex 11 homolog (m ...... |
Chromosomal Location | 6p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TCP11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TCP11 |
Name | t-complex 11, testis-specific |
Aliases | FPPR; fertilization-promoting peptide receptor; t-complex 11 (a murine tcp homolog); t-complex 11 homolog (m ...... |
Chromosomal Location | 6p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TCP11 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | TCP11 |
Name | t-complex 11, testis-specific |
Aliases | FPPR; fertilization-promoting peptide receptor; t-complex 11 (a murine tcp homolog); t-complex 11 homolog (m ...... |
Chromosomal Location | 6p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TCP11 in various data sets.
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Points in the above scatter plot represent the mutation difference of TCP11 in various data sets.
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Summary | |
---|---|
Symbol | TCP11 |
Name | t-complex 11, testis-specific |
Aliases | FPPR; fertilization-promoting peptide receptor; t-complex 11 (a murine tcp homolog); t-complex 11 homolog (m ...... |
Chromosomal Location | 6p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TCP11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | TCP11 |
Name | t-complex 11, testis-specific |
Aliases | FPPR; fertilization-promoting peptide receptor; t-complex 11 (a murine tcp homolog); t-complex 11 homolog (m ...... |
Chromosomal Location | 6p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TCP11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TCP11. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TCP11 |
Name | t-complex 11, testis-specific |
Aliases | FPPR; fertilization-promoting peptide receptor; t-complex 11 (a murine tcp homolog); t-complex 11 homolog (m ...... |
Chromosomal Location | 6p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TCP11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TCP11 |
Name | t-complex 11, testis-specific |
Aliases | FPPR; fertilization-promoting peptide receptor; t-complex 11 (a murine tcp homolog); t-complex 11 homolog (m ...... |
Chromosomal Location | 6p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TCP11 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | TCP11 |
Name | t-complex 11, testis-specific |
Aliases | FPPR; fertilization-promoting peptide receptor; t-complex 11 (a murine tcp homolog); t-complex 11 homolog (m ...... |
Chromosomal Location | 6p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TCP11 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TCP11 |
Name | t-complex 11, testis-specific |
Aliases | FPPR; fertilization-promoting peptide receptor; t-complex 11 (a murine tcp homolog); t-complex 11 homolog (m ...... |
Chromosomal Location | 6p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TCP11 collected from DrugBank database. |
There is no record. |